Abstract: Provided herein are compounds that act as molecular glues, inducing degradation of CK1? or CK1?/GSPT1, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with a proliferative disease.

Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: A high lift dump truck having a chassis on a truck, and a body portion having a tailgate being positioned on the chassis and being supported in a lowered position. A front hoist having a first end pivotably mounted at a generally central location on the chassis. The front hoist has a second end pivotably mounted on the body and the front hoist is positioned to raise the body to a maximum front elevation above the chassis. A rear hoist has a first end pivotably mounted at a generally rear location on the chassis and a rear hoist has a second end pivotably mounted on the body generally near the tailgate end of the body. The rear hoist is positioned to raise the body to a maximum rear elevation above the chassis. A control link has a first end pivotably mounted on the chassis adjacent the rear location and has a second end mounted on the body at a generally central location, whereby the link defines a locus of movement of the second end when the body is raised.