Abstract: A unique aerosol-compatible cell culture exposure system is described that allow serial dilution and delivery of aerosols, reactive gases, and VOCs at air-liquid interface (ALI) under physiologically relevant conditions. Generally, the cell culture system comprise one or more dilution manifolds, one or more flow splitters, and a sealed exposure chamber that houses a commercially-available cell culture plate with corresponding transwells.

Abstract: An optical device includes a first optically dimmable switch for providing a first transmittance while the first optically dimmable switch is in a first state and providing a second transmittance distinct from the first transmittance while the first optically dimmable switch is in a second state distinct from the first state. The optical device also includes a dynamic heat source thermally coupled with the first optically dimmable switch. The dynamic heat source is at a first temperature at a first time and is at a second temperature distinct from the first temperature at a second time mutually exclusive from the first time. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Provided herein are compounds of formula (I): and pharmaceutically-acceptable salts thereof, where A, W, X, Y and Z are defined in the specification. The compounds of formula (I) and pharmaceutically-acceptable salts thereof are Janus kinase (JAK) inhibitors. Also provided herein are pharmaceutical compositions comprising such compounds; and methods of using such compounds to treat, e.g., inflammatory and fibrotic diseases, including respiratory diseases.

Abstract: A workload of a database may be evaluated to provide a database migration recommendation. A request for a recommendation to migrate a database to a new host may be received. An evaluation of the workload of a client application of the database at a current host may be performed. The migration recommendation may be returned based on the evaluation of the workload of the client application of the database. In some embodiments, the migration recommendation may trigger an automated migration of the database to the new host.

Abstract: A nozzle for an ionisation source comprises: a light passage having an inlet end and an outlet end; and a gas flow passage in fluid communication with the light passage, wherein the gas flow passage is configured to convey, in use, a flow of gas into the light passage such that the flow of gas travels substantially towards the outlet end of the light passage.

Abstract: A system to facilitate a container orchestration cloud service platform is described. The system includes a controller to manage Kubernetes cluster life-cycle operations created by each of a plurality of providers. The controller includes one or more processors to execute a controller micro service to discover a provider plugin associated with each of the plurality of providers, and perform the cluster life-cycle operations at a container orchestration platform as a broker for each of a plurality of providers.

Abstract: A pen needle shield assembly comprising a hub fixed to a needle cannula, and a movable shield surrounding the hub, the movable shield comprising an upper portion having an outer diameter, a lower portion having an outer diameter greater than the outer diameter of the upper portion, and a distal opening, wherein the movable shield moves from a first position where the needle cannula is retracted in the movable shield prior to use, to a second position where the needle cannula is extended out of the movable shield through the distal opening for medication delivery and to a third position where the needle cannula is retracted in the movable shield and locked to prevent further use.

Abstract: Disclosed are embodiments that provide digital data communication between a single-pair Ethernet and a multi-pair Ethernet. Some embodiments include a single-pair Ethernet interface that is configured to operate in at least two modes. In a first mode, the single-pair Ethernet interface operates in a conventional manner. In a second mode, alternate pin configurations are employed to provide a low-cost interoperability between a single-pair Ethernet interface and a multi-pair Ethernet interface. For example, in the second mode, the single-pair Ethernet receives, via a first receive data pin, from a first transmit data pin of the multi-pair Ethernet interface, a data signal, and receives, via a second receive data pin, from a second transmit data pin of the multi-pair Ethernet interface, a second data signal.

Abstract: A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.

Abstract: A method of forming a low reflectivity coating on an optical surface for wide angle of incidence is provided. The method includes depositing a low refractive index layer of material on a stack of dielectric layers, depositing a hydrophobic compatible material on the stack of dielectric layers, forming a blend interface layer on the stack of dielectric layers, the blend interface layer including a portion of the low refractive index layer of material and a portion of the hydrophobic compatible material, and depositing a hydrophobic layer of material adjacent to the blend interface layer. A physical vapor deposition chamber to perform the above method is also provided.

Abstract: A mass spectrometer is disclosed comprising a rotatable isolation valve (1) having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide (2) is positioned so as to extend within a swept volume of the isolation valve (1) enabling the ion guide (2) to be positioned close to a second downstream ion guide (3) and for ions to be transmitted from the first (2) ion guide to the second ion guide (3) with high ion transmission efficiency.

Abstract: Example implementations relate to exposing on-premise API endpoints in a cloud-based application platform. The application platform receives information regarding a forwarding proxy associated with a private network and information regarding a remote application programming interface (API) endpoint within the private network. A mapping between a resource model of the application platform to a tunnel established between a forwarding client of the application platform and the forwarding proxy is created by a controller of the application platform causing the forwarding client to instantiate a port corresponding to a forwarding route for the remote API endpoint based on the information regarding the forwarding proxy and the remote API endpoint. The remote API endpoint is locally represented within the application platform in a form of an instance of a service abstraction provided by the application platform.

Abstract: A nozzle for an ionisation source comprises: a light passage having an inlet end and an outlet end; and a gas flow passage in fluid communication with the light passage, wherein the gas flow passage is configured to convey, in use, a flow of gas into the light passage such that the flow of gas travels substantially towards the outlet end of the light passage.

Abstract: Systems and methods for using dynamic actionable notifications are disclosed. The method includes: receiving, at a client device, a dynamic actionable notification associated with an event at a remote server, the dynamic actionable notification including one or more action items associated with the event; detecting user interaction with the dynamic actionable notification; retrieving current status of the one or more action items from the remote server; displaying one or more actionable graphical elements in a user interface of the dynamic actionable notification based on the retrieved current status of the one or more action items.

Abstract: Example implementations relate to exposing on-premise API endpoints in a cloud-based application platform. The application platform receives information regarding a forwarding proxy associated with a private network and information regarding a remote application programming interface (API) endpoint within the private network. A mapping between a resource model of the application platform to a tunnel established between a forwarding client of the application platform and the forwarding proxy is created by a controller of the application platform causing the forwarding client to instantiate a port corresponding to a forwarding route for the remote API endpoint based on the information regarding the forwarding proxy and the remote API endpoint. The remote API endpoint is locally represented within the application platform in a form of an instance of a service abstraction provided by the application platform.

Abstract: Disclosed are embodiments that provide digital data communication between a single-pair Ethernet and a multi-pair Ethernet. Some embodiments include a single-pair Ethernet interface that is configured to operate in at least two modes. In a first mode, the single-pair Ethernet interface operates in a conventional manner. In a second mode, alternate pin configurations are employed to provide a low-cost interoperability between a single-pair Ethernet interface and a multi-pair Ethernet interface. For example, in the second mode, the single-pair Ethernet receives, via a first receive data pin, from a first transmit data pin of the multi-pair Ethernet interface, a data signal, and receives, via a second receive data pin, from a second transmit data pin of the multi-pair Ethernet interface, a second data signal.

Abstract: A system and method for managing collateralized term transactions between two counterparties, employed by a third party, utilizing a novel margining process integrating escrow accounts and regularly rebalancing the notional amount of the transaction. The system and method allows far wider applicability to different forms of collateral and allows unfamiliar or lesser credit-worthy counterparties to transact.

Abstract: Example implementations relate to exposing on-premise API endpoints in a cloud-based application platform. The application platform receives information regarding a forwarding proxy associated with a private network and information regarding a remote application programming interface (API) endpoint within the private network. A mapping between a resource model of the application platform to a tunnel established between a forwarding client of the application platform and the forwarding proxy is created by a controller of the application platform causing the forwarding client to instantiate a port corresponding to a forwarding route for the remote API endpoint based on the information regarding the forwarding proxy and the remote API endpoint. The remote API endpoint is locally represented within the application platform in a form of an instance of a service abstraction provided by the application platform.

Abstract: Described herein is technology for replicating data from a source database to one or more target databases at different points in time. The system receives a request to replicate a data set stored in a source database. The system stores a copy of a first subset of the data set from the source database to a target database at a first time. The system stores a copy of a second subset of the data set from the source database to the target database at a second time.