Abstract: A method of requesting and issuing a certificate from certification authority for use by an initiating correspondent with a registration authority is provided. The initiating correspondent makes a request for a certificate to the registration authority, and the registration authority sends the request to a certificate authority, which issues the certificate to the registration authority. The certificate is stored at a location in a directory and this location is associated with a pointer such as uniform resource locator (URL) that is derived from information contained in the certificate request. The initiating correspondent computes the location using the same information and forwards it to other corespondents. The other correspondents can then locate the certificate to authenticate the public key of the initiating correspondent.

Abstract: Various techniques are disclosed for operating a gaming device of a casino gaming network. In at least one embodiment, the gaming device includes a tournament manager and a first meter. In at least one embodiment, the first meter is operable to: receive a first meter update request for changing meter state information and/or meter data associated with the first meter; determine whether at least one condition exists for denying the first meter update request; and/or prevent execution of the first meter update request in response to a determination that at least one condition exists for denying the first meter update request.

Abstract: A method of requesting and issuing a certificate from certification authority for use by an initiating correspondent with a registration authority is provided. The initiating correspondent makes a request for a certificate to the registration authority, and the registration authority sends the request to a certificate authority, which issues the certificate to the registration authority. The certificate is stored at a location in a directory and this location is associated with a pointer such as uniform resource locator (URL) that is derived from information contained in the certificate request. The initiating correspondent computes the location using the same information and forwards it to other corespondents. The other correspondents can then locate the certificate to authenticate the public key of the initiating correspondent.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+—O? or CR3; Y is N, N+—O? or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Abstract: A kit for fixing tiles to a wall comprising: a tile having a protrusion extending from an edge thereof; and a fixing element arranged to be fastened to the wall and to accommodate the protrusion so as to secure the tile in position.

Abstract: A method of requesting and issuing a certificate from certification authority for use by an initiating correspondent with a registration authority is provided. The initiating correspondent makes a request for a certificate to the registration authority, and the registration authority sends the request to a certificate authority, which issues the certificate to the registration authority. The certificate is stored at a location in a directory and this location is associated with a pointer such as uniform resource locator (URL) that is derived from information contained in the certificate request. The initiating correspondent computes the location using the same information and forwards it to other corespondents. The other correspondents can then locate the certificate to authenticate the public key of the initiating correspondent.

Abstract: A method of requesting and issuing a certificate from certification authority for use by an initiating correspondent with a registration authority is provided. The initiating correspondent makes a request for a certificate to the registration authority, and the registration authority sends the request to a certificate authority, which issues the certificate to the registration authority. The certificate is stored at a location in a directory and this location is associated with a pointer such as uniform resource locator (URL) that is derived from information contained in the certificate request. The initiating correspondent computes the location using the same information and forwards it to other corespondents. The other correspondents can then locate the certificate to authenticate the public key of the initiating correspondent.

Abstract: Various techniques are disclosed for operating a gaming device of a casino gaming network. In at least one embodiment, the gaming device includes a tournament manager and a first meter. In at least one embodiment, the first meter is operable to: receive a first meter update request for changing meter state information and/or meter data associated with the first meter; determine whether at least one condition exists for denying the first meter update request; and/or prevent execution of the first meter update request in response to a determination that at least one condition exists for denying the first meter update request.

Abstract: The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+—O? or CR3; Y is N, N+—O? or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Abstract: Various techniques are disclosed for operating a gaming device of a casino gaming network. In at least one embodiment, the gaming device includes a tournament manager and a first meter. In at least one embodiment, the first meter is operable to perform one or more of the following (or combinations thereof): receive a first meter update request for changing meter state information and/or meter data associated with the first meter; determine whether at least one condition exists for denying the first meter update request; and/or prevent execution of the first meter update request in response to a determination that at least one condition exists for denying the first meter update request.

Abstract: A night vision system comprising a power system having a low voltage unit coupled to a high voltage unit; the low voltage unit including a low voltage controller generating a pulse width code; the high voltage unit including an opto-isolator for receiving the pulse width code from the low voltage controller, a high voltage controller operative in response to the pulse width code to generate an output pulse, a pulse shaping module receiving the output pulse and generating a control pulse; and power electronics operative in response to the control pulse.

Abstract: The invention provides a cyclin dependent kinase (e.g. cdk-4 kinase) inhibitor of the formula (I) or a salt, tautomer, solvate or N-oxide thereof; wherein R1 is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group containing 0-2 heteroatoms selected from O, N and S wherein the optional substituents are selected from halogen, C1-4 alkyl, C1-4 alkoxy, C3-4 cycloalkyl and cyano, and wherein the C1-4 alkyl and C1-4 alkoxy groups are each optionally further substituted by C1-2 alkoxy or one or more halogen atoms; and E is a group E1, E2, E3 or E4: formulae E1, E2, E3, E4 wherein n, q, A5 B, T, U, V, W, Z, R2, R5, R6 and R7 are as defined in the claims.

Abstract: A night vision system comprising a power system having a low voltage unit coupled to a high voltage unit. The low voltage unit includes a low voltage controller and a low voltage table correlating step values to pulse widths, the low voltage controller obtaining a desired pulse width and accessing the table to obtain a step value. The low voltage unit transmits the step value to the high voltage unit using a pulse count modulation format. The high voltage unit includes an opto-isolator for receiving the step value from the low voltage controller and a high voltage controller demodulating the step value. In response to the step value, the high voltage controller accesses a high voltage table correlating step values to pulse width to obtain a pulse width, the high voltage controller generating a control pulse in response to the pulse width.

Abstract: Various techniques are disclosed for operating a gaming device of a casino gaming network. In at least one embodiment, the gaming device includes a tournament manager and a first meter. In at least one embodiment, the first meter is operable to perform one or more of the following (or combinations thereof): receive a first meter update request for changing meter state information and/or meter data associated with the first meter; determine whether at least one condition exists for denying the first meter update request; and/or prevent execution of the first meter update request in response to a determination that at least one condition exists for denying the first meter update request.

Abstract: A night vision system including a power system having a low voltage unit coupled to a high voltage unit. The low voltage unit includes a low voltage controller and a low voltage table correlating step values to pulse widths, the low voltage controller obtaining a desired pulse width and accessing the table to obtain a step value. The high voltage unit including an opto-isolator for receiving the step value from the low voltage controller, a high voltage controller response to the step value accessing a high voltage table correlating step values to pulse width to obtain a pulse width, the high voltage controller generating a control pulse in response to the pulse width.

Abstract: A night vision system including a power system having a low voltage unit coupled to a high voltage unit. The low voltage unit includes a low voltage controller and a low voltage table correlating pulse widths to step values. The low voltage unit transmits the step value to the high voltage unit in a pulse train having a period corresponding to a frequency. The high voltage unit including an opto-isolator for receiving the step value from the low voltage controller, a high voltage controller accessing a high voltage table correlating step value to pulse width and threshold. The high voltage controller generates control pulses at the frequency in response to the pulse width and the threshold.

Abstract: A method of requesting and issuing a certificate from certification authority for use by an initiating correspondent with a registration authority is provided. The initiating correspondent makes a request for a certificate to the registration authority, and the registration authority sends the request to a certificate authority, which issues the certificate to the registration authority. The certificate is stored at a location in a directory and this location is associated with a pointer such as uniform resource locator (URN) that is derived from information contained in the certificate request. The initiating correspondent computes the location using the same information and forwards it to other corespondents. The other correspondents can then locate the certificate to authenticate the public key of the initiating correspondent.

Abstract: A method of treating earthenware bodies to enhance resistance to freezing and to assist the application of decals and the like thereto comprises treating the bodies with a liquid medium containing a water-repellent material such as silicone. In a subsequent drying step, the bulk of the liquid medium is removed while leaving the water-repellent material deposited in the pores of the earthenware body. In this way, subsequent entry of water and freezing and cracking is resisted. It has also been discovered that the treatment also enchances the ability of the earthenware surface to receive decals and the like without the need for glazing and an additional firing step.