Patents by Inventor Paul O'Malley
Paul O'Malley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240081808Abstract: Methods and devices for tissue fixation. A cortical button with a rib between two slotted openings. The rib increases the cortical button structural rigidity without increasing palpability. An adjustable loop construct with two discrete locking passages that provides manageable loop reduction and improved tissue coupling. The adjustable loop construct may be coupled to tissue via a passing construct. An assembly with a reduction bar, a button and an adjustable loop construct, the assembly provided assembled in a first configuration that disassembles to guide steps of tissue fixation. The reduction bar may be assembled to the reduction bar for reducing the adjustable loop construct.Type: ApplicationFiled: April 26, 2022Publication date: March 14, 2024Inventors: ALI HOSSEINI, Christopher David MacCready, Kendra O'Malley, Geoffrey Ian Karasic, Zenan Qi, Benjamin Michael Hall, Chun Liu, Paul McGovern, Han Teik Yeoh
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Patent number: 11564878Abstract: A three-part method of cleaning a user's teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user's teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.Type: GrantFiled: June 7, 2021Date of Patent: January 31, 2023Inventor: Paul O'Malley
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Publication number: 20220226603Abstract: Kits are provided for storing, transporting, and sterilizing reusable urinary catheters. A reusable urinary catheter stored within a housing of the kit may be sterilized between uses using a sterilization fluid or sterilizing light. If the reusable urinary catheter is sterilized using a sterilization fluid, the housing may include a manually actuated or electromechanical pump to circulate the sterilization fluid through the housing. The reusable urinary catheter may include a funnel secured to a catheter shaft, with a plurality of lateral openings defined in the funnel, which provide fluid communication between an interior of the funnel and an external surface of the catheter shaft. By allowing fluid communication between the interior of the funnel and the external surface of the catheter shaft, the lateral openings allow for fluid sterilization of both internal and external surfaces of the catheter shaft.Type: ApplicationFiled: June 10, 2020Publication date: July 21, 2022Inventors: Michael G. Murray, Horacio Montes De Oca, Gary W. lnglese, Rebecca M. Leece, Sean McNulty, Jerome A. Henry, Dean W. Hacker, Padraig M. O'Flynn, Martin McMenamin, David J. Farrell, Paul O'Malley
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Publication number: 20210378945Abstract: A three-part method of cleaning a user's teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user's teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.Type: ApplicationFiled: June 7, 2021Publication date: December 9, 2021Inventor: Paul O'Malley
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Patent number: 10729810Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.Type: GrantFiled: July 18, 2014Date of Patent: August 4, 2020Assignees: CAYMAN CHEMICAL COMPANY, INC, MYOMETRICS LLCInventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Gregory William Endres, Fred Lawrence Ciske, Thomas Allen Owen, James Paul O'Malley
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Publication number: 20190144435Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: ApplicationFiled: January 9, 2019Publication date: May 16, 2019Applicant: Myometrics, LLCInventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endress, Bradlee David Germain, Andriy Komilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Publication number: 20170260173Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: ApplicationFiled: May 18, 2017Publication date: September 14, 2017Applicant: Myometrics, LLCInventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endress, Bradlee David Germain, Andriy Komilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Patent number: 9701630Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: GrantFiled: August 2, 2016Date of Patent: July 11, 2017Assignees: Cayman Chemical Company, Inc., Myometrics, LLCInventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endres, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Patent number: 9688627Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.Type: GrantFiled: March 14, 2014Date of Patent: June 27, 2017Assignee: CAYMAN CHEMICAL COMPANY, INC.Inventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Gregory William Endres, Andriy Komilov, James Bernard Kramer, Adam Uzieblo, Fred Lawrence Ciske, Kirk M. Maxey, James Paul O'Malley, Thomas Allen Owen
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Patent number: 9676712Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.Type: GrantFiled: March 14, 2014Date of Patent: June 13, 2017Assignee: CAYMAN CHEMICAL COMPANY, INC.Inventors: Stephen Douglas Barrett, Bradlee David Germain, Adam Uzieblo, Fred Lawrence Ciske, Gregory William Endres, Andriy Kornilov, Kirk M. Maxey, James Paul O'Malley, Thomas Allen Owen
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Patent number: 9603791Abstract: A probiotic formulation includes the following: lactobacillus acidophilus comprising 15.0% to 40.0% per mass of the probiotic formulation; lactobacillus reuteri comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus salivarius comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus paracasei comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus thermophiles comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus salivarius BLIS K-12 comprising 5.0% to 30.0% per mass of the probiotic formulation; streptococcus salivarius BLIS M-18 comprising 5.0% to 30.0% per mass of the probiotic formulation; zinc oxide comprising 0.2% to 5.0% per mass of the probiotic formulation; hydroxyapatite comprising 0.1% to 25.0% per mass of the probiotic formulation; and dicalcium phosphate comprising 0.1% to 5.0% per mass of the probiotic formulation. The probiotic formulation may be formed into a lozenge or a gum.Type: GrantFiled: June 30, 2016Date of Patent: March 28, 2017Inventor: Paul O'Malley
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Patent number: 9554973Abstract: A two-part oral care system includes a plurality of micro-encapsulated vessels containing an oxidative composition inside a coating, the oxidative composition having a pH less than 7.5, and a reductant composition, the reductant composition having a pH greater than 7. The micro-encapsulated vessels isolate the oxidative and reductant compositions from reacting with one another during storage and wherein the micro-encapsulated vessels can dispense when ruptured the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil comprising 0.01% to 5.0% per mass of the final composition and an oxidant comprising 0.01% to 2.0% per mass of the final composition. The reductant composition may include an aloe gel, xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt, a bromelain, a papain, and at least one essential oil.Type: GrantFiled: August 3, 2016Date of Patent: January 31, 2017Inventor: Paul O'Malley
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Publication number: 20160338916Abstract: A two-part oral care system includes a plurality of micro-encapsulated vessels containing an oxidative composition inside a coating, the oxidative composition having a pH less than 7.5, and a reductant composition, the reductant composition having a pH greater than 7. The micro-encapsulated vessels isolate the oxidative and reductant compositions from reacting with one another during storage and wherein the micro-encapsulated vessels can dispense when ruptured the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil comprising 0.01% to 5.0% per mass of the final composition and an oxidant comprising 0.01% to 2.0% per mass of the final composition. The reductant composition may include an aloe gel, xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt, a bromelain, a papain, and at least one essential oil.Type: ApplicationFiled: August 3, 2016Publication date: November 24, 2016Inventor: Paul O'Malley
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Publication number: 20160340306Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: ApplicationFiled: August 2, 2016Publication date: November 24, 2016Inventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endres, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Publication number: 20160310407Abstract: A probiotic formulation includes the following: lactobacillus acidophilus comprising 15.0% to 40.0% per mass of the probiotic formulation; lactobacillus reuteri comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus salivarius comprising 5.0% to 20.0% per mass of the probiotic formulation; lactobacillus paracasei comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus thermophiles comprising 5.0% to 20.0% per mass of the probiotic formulation; streptococcus salivarius BLIS K-12 comprising 5.0% to 30.0% per mass of the probiotic formulation; streptococcus salivarius BLIS M-18 comprising 5.0% to 30.0% per mass of the probiotic formulation; zinc oxide comprising 0.2% to 5.0% per mass of the probiotic formulation; hydroxyapatite comprising 0.1% to 25.0% per mass of the probiotic formulation; and dicalcium phosphate comprising 0.1% to 5.0% per mass of the probiotic formulation. The probiotic formulation may be formed into a lozenge or a gum.Type: ApplicationFiled: June 30, 2016Publication date: October 27, 2016Inventor: Paul O'Malley
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Patent number: 9440919Abstract: Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: GrantFiled: July 19, 2013Date of Patent: September 13, 2016Assignees: Cayman Chemical Company, Inc., Myometrics, LLCInventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endres, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Patent number: 9403181Abstract: A two-part oral care system includes a first vessel containing an oxidative composition having a pH less than 7.5 and a second vessel containing a reductant composition having a pH greater than 7. The first and second vessels isolate the oxidative and reductant compositions from reacting with one another during storage and the vessels can dispense the oxidative and reductant compositions for combining to result in a final composition for use. The oxidative composition includes an ozonated oil and an oxidant. The reductant composition includes an aloe gel or aloe vera, a xylitol, a ferrous sulfate, a sodium bicarbonate, a calcium carbonate, a zinc gluconate, a salt comprising, a bromelain, a papain and at least one essential oil. A probiotic lozenge may also be used after the two-part oral care system to install good bacteria.Type: GrantFiled: July 25, 2014Date of Patent: August 2, 2016Inventor: Paul O'Malley
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Publication number: 20160158413Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.Type: ApplicationFiled: July 18, 2014Publication date: June 9, 2016Applicants: CAYMAN CHEMICAL COMPANY, INC., MYOMETRICS LLCInventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Gregory William Endres, Fred Lawrence Ciske, Thomas Allen Owen, James Paul O'Malley
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Publication number: 20160060216Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.Type: ApplicationFiled: March 14, 2014Publication date: March 3, 2016Inventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Gregory William Endres, Andriy Komilov, James Bernard Kramer, Adam Uzieblo, Fred Lawrence Ciske, Kirk M. Maxey, James Paul O'Malley, Thomas Allen Owen
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Publication number: 20160031811Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Inventors: Stephen Douglas Barrett, Bradlee David Germain, Adam Uzieblo, Fred Lawrence Ciske, Gregory William Endres, Andriy Kornilov, Kirk M. Maxey, James Paul O'Malley, Thomas Allen Owen