Patents by Inventor Paul O'Neill

Paul O'Neill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11978565
    Abstract: A sodium-cooled nuclear reactor includes at least one electromagnetic pump assembly and a backflow reduction pipe. The backflow reduction pipe may include an inlet, an outlet, at least one tubular section having a first length and a first diameter, and at least one fluid diode section between the inlet and the outlet.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: May 7, 2024
    Assignee: GE-HITACHI NUCLEAR ENERGY AMERICAS LLC
    Inventors: Eric Paul Loewen, Seth Ryan Paul Strege, Nicholas Francis O′Neill, Colin Christopher O′Connor, Chelsea Ann Curtin, Edwin Wu
  • Publication number: 20240033222
    Abstract: This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an ?-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 1, 2024
    Applicant: NORTON (WATERFORD) LIMITED
    Inventors: Brian Paul O'NEILL, Hardik Kirtikumar SHAH, Julian Alexander BLAIR, Chris David EDLIN, Shane Michael MCKEON
  • Publication number: 20230255983
    Abstract: This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an ?-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.
    Type: Application
    Filed: April 25, 2023
    Publication date: August 17, 2023
    Inventors: Brian Paul O'Neill, Hardik Kirtikumar Shah, Julian Alexander Blair, Chris David Edlin, Shane Michael McKeon
  • Patent number: 11638710
    Abstract: This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an ?-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: May 2, 2023
    Assignee: NORTON (WATERFORD) LIMITED
    Inventors: Brian Paul O'Neill, Hardik Kirtikumar Shah, Julian Alexander Blair, Chris David Edlin, Shane Michael McKeon
  • Patent number: 11637687
    Abstract: Methods, apparatus, systems and articles of manufacture to determine provenance for data supply chains are disclosed. Example instructions cause a machine to at least, in response to data being generated, generate a local data object and object metadata corresponding to the data; hash the local data object; generate a hash of a label of the local data object; generate a hierarchical data structure for the data including the hash of the local data object and the hash of the label of the local data object; generate a data supply chain object including the hierarchical data structure; and transmit the data and the data supply chain object to a device that requested access to the data.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: April 25, 2023
    Assignee: Intel Corporation
    Inventors: Ned Smith, Francesc Guim Bernat, Sanjay Bakshi, Paul O'Neill, Ben McCahill, Brian A. Keating, Adrian Hoban, Kapil Sood, Mona Vij, Nilesh Jain, Rajesh Poornachandran, Trevor Cooper, Kshitij A. Doshi, Marcin Spoczynski
  • Publication number: 20220047610
    Abstract: This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an ?-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.
    Type: Application
    Filed: August 24, 2021
    Publication date: February 17, 2022
    Applicant: Norton (Waterford) Limited
    Inventors: Brian Paul O'Neill, Hardik Kirtikumar Shah, Julian Alexander Blair, Chris David Edlin, Shane Michael McKeon
  • Publication number: 20220031676
    Abstract: Provided herein are methods for the treatment of disease with monoacylglycerol lipase (MAGL) inhibitors.
    Type: Application
    Filed: November 26, 2019
    Publication date: February 3, 2022
    Inventors: Channing Rodney BEALS, Dallas JONES, Jason Robert CLAPPER, Gary Paul O'NEILL, Iain Peter FRASER, Jacqueline Lorayne BLANKMAN, John J.M. WIENER, Cheryl A. GRICE
  • Publication number: 20210230145
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Inventors: Jacqueline Lorayne BLANKMAN, Jason Robert CLAPPER, R. Alan B. EZEKOWITZ, Iain Peter FRASER, Cheryl A. GRICE, Todd K. JONES, Gary Paul O'NEILL, Archie Wayne THURSTON, JR., Channing Rodney BEALS
  • Patent number: 11034674
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: June 15, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
  • Publication number: 20200136799
    Abstract: Methods, apparatus, systems and articles of manufacture to determine provenance for data supply chains are disclosed. Example instructions cause a machine to at least, in response to data being generated, generate a local data object and object metadata corresponding to the data; hash the local data object; generate a hash of a label of the local data object; generate a hierarchical data structure for the data including the hash of the local data object and the hash of the label of the local data object; generate a data supply chain object including the hierarchical data structure; and transmit the data and the data supply chain object to a device that requested access to the data.
    Type: Application
    Filed: December 20, 2019
    Publication date: April 30, 2020
    Inventors: Ned Smith, Francesc Guim Bernat, Sanjay Bakshi, Paul O'Neill, Ben McCahill, Brian A. Keating, Adrian Hoban, Kapil Sood, Mona Vij, Nilesh Jain, Rajesh Poornachandran, Trevor Cooper, Kshitij A. Doshi, Marcin Spoczynski
  • Publication number: 20200055841
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Application
    Filed: September 6, 2019
    Publication date: February 20, 2020
    Inventors: Jacqueline Lorayne BLANKMAN, Jason Robert CLAPPER, R. Alan B. EZEKOWITZ, Iain Peter FRASER, Cheryl A. GRICE, Todd K. JONES, Gary Paul O'NEILL, Archie Wayne THURSTON, JR., Channing Rodney BEALS
  • Patent number: 10450302
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 22, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
  • Patent number: 10449198
    Abstract: The present invention relates to a method of treating pain in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate: wherein Q is as defined herein.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: October 22, 2019
    Assignee: The University of Liverpool
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Publication number: 20190078376
    Abstract: A prefabricated window sill 10 suitable for external use comprises a closed cast outer shell 12 having at least an upper surface 16, a lower surface 18, a front surface 20, a rear surface 22 and first and second end surfaces 24, 26. The shell is made from a composite of a plastic polyester resin mixed with either crushed marble or crushed glass, with a catalyst which causes the resin to set; the shell being filled with an expanded plastics foam.
    Type: Application
    Filed: November 13, 2018
    Publication date: March 14, 2019
    Inventors: Daniel Callaghan, Richard Benson, Andrew Corkery, Paul O'Neill
  • Publication number: 20190000853
    Abstract: The present invention relates to certain antiviral compounds of formula I as defined herein that function as nucleoside reverse transcriptase inhibitors. The present invention also relates to processes for the preparation of these compounds, pharmaceutical compositions comprising them and to their use for the treatment of retroviral infections, and in particular their use in the treatment of HIV-1 virus.
    Type: Application
    Filed: July 29, 2016
    Publication date: January 3, 2019
    Inventors: Paul O'NEILL, Neil BERRY
  • Publication number: 20180140608
    Abstract: The present invention relates to a method of treating pain in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate: wherein Q is as defined herein.
    Type: Application
    Filed: July 5, 2017
    Publication date: May 24, 2018
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Patent number: 9944653
    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: April 17, 2018
    Assignee: THE UNIVERSITY OF LIVERPOOL
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Publication number: 20180099951
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Application
    Filed: May 10, 2016
    Publication date: April 12, 2018
    Inventors: Jacqueline Lorayne BLANKMAN, Jason Robert CLAPPER, R. Alan B. EZEKOWITZ, Iain Peter FRASER, Cheryl A. GRICE, Todd K. JONES, Gary Paul O'NEILL, Archie Wayne THURSTON, Jr., Channing Rodney BEALS
  • Publication number: 20170298076
    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: May 4, 2017
    Publication date: October 19, 2017
    Inventors: Martin Leuwer, Paul O'Neill, Neil Berry, Chandrakala Pidathala
  • Publication number: 20170204655
    Abstract: A prefabricated window sill (10) suitable for external use comprises a closed cast outer shell (12) having at least an upper surface (16), a lower surface (18), a front surface (20), a rear surface (22) and first and second end surfaces (24, 26). The shell is made from a composite of a plastic polyester resin mixed with either crushed marble or crushed glass, with a catalyst which causes the resin to set; the shell being filled with an expanded plastics foam.
    Type: Application
    Filed: February 3, 2015
    Publication date: July 20, 2017
    Inventors: Daniel Callaghan, Richard Benson, Andrew Corkery, Paul O'Neill