Patents by Inventor Paul P. Hung
Paul P. Hung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240107177Abstract: Embodiments disclosed herein are directed to devices and methods for performing spatially-varying brightness correction of a flash image. The spatially-varying brightness correction utilizes a set of images that includes one or more images captured under flash illumination and one or more images captured without flash illumination, which are used to decompose one of the flash images or an image generated therefrom into a flash contribution image and an ambient contribution image. The flash contribution image and the ambient contribution image are recombined to generate a corrected flash image, and information about the flash module and/or scene is used to adjust the relative contributions of these images during recombination.Type: ApplicationFiled: September 22, 2022Publication date: March 28, 2024Inventors: Bosheng Zhang, Tobias Baldauf, llya Romanenko, Nicolas P. Bonnier, Noah D. Bedard, Alexandra S. Ludlow, Graham D. Finlayson, Jason P. de Villiers, Claus Moelgaard, Hau Ling Hung, Paul M. Hubel
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Publication number: 20040170647Abstract: This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.Type: ApplicationFiled: March 5, 2004Publication date: September 2, 2004Applicant: WyethInventors: Alan R. Davis, Michael D. Lubeck, Robert J. Natuk, Pranab K. Chanda, Shridhara C. S. Murthy, Shaw-Guang L. Lee, Paul P. Hung
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Patent number: 6511845Abstract: This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.Type: GrantFiled: July 18, 2000Date of Patent: January 28, 2003Inventors: Alan R. Davis, Paul P. Hung, Michael D. Lubeck, Robert J. Natuk, Pranab K. Chanda, Shridhara C. S. Murthy, Shaw-Guang L. Lee
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Patent number: 5643579Abstract: Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.Type: GrantFiled: July 29, 1994Date of Patent: July 1, 1997Assignee: American Home Products CorporationInventors: Paul P. Hung, Alan R. Davis
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Patent number: 5591823Abstract: Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.Type: GrantFiled: December 17, 1993Date of Patent: January 7, 1997Assignee: American Home Products CorporationInventors: Paul P. Hung, Shaw-Guang L. Lee, Narender K. Kalyan
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Patent number: 5376547Abstract: Des-epidermal growth factor homologous--plasminogen activators with greatly diminished affinity for liver membranes.Type: GrantFiled: January 29, 1988Date of Patent: December 27, 1994Assignee: American Home Products CorporationInventors: Narender K. Kalyan, Shawguang L. Lee, Paul P. Hung
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Patent number: 5047241Abstract: Tris-Kringle plasminogen activators containing an additional second kringle domain or an additional modified second kringle domain are useful in disrupting blood clots.Type: GrantFiled: December 31, 1987Date of Patent: September 10, 1991Assignee: American Home Products CorporationInventors: Paul P. Hung, Narender K. Kalyan, Shawguang L. Lee
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Patent number: 5045315Abstract: Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.Type: GrantFiled: October 23, 1990Date of Patent: September 3, 1991Assignee: American Home Products CorporationInventors: Paul P. Hung, Narender K. Kalyan, Shaw-guang L. Lee
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Patent number: 4997766Abstract: Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators. Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.Type: GrantFiled: November 14, 1989Date of Patent: March 5, 1991Assignee: American Home Products CorporationInventors: Paul P. Hung, Narender K. Kalyan, Shaw-guang L. Lee
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Patent number: 4920209Abstract: Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.Type: GrantFiled: June 4, 1987Date of Patent: April 24, 1990Assignee: American Home Products CorporationInventors: Alan R. Davis, Paul P. Hung
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Patent number: 4916071Abstract: Hybrid, third generation, plasminogen activators containing plural, heterologous polypeptide kringles prepared by recombinant DNA techniques as well as the genes coding for the activators, Vectors containing those genes and a method for using the plasminogen activators as thrombolytic agents, are disclosed.Type: GrantFiled: July 11, 1986Date of Patent: April 10, 1990Assignee: American Home Products CorporationInventors: Paul P. Hung, Narender K. Kalyan, Shaw-guang L. Lee
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Patent number: 4743619Abstract: The invention disclosed herein provides a method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected from a group consisting of(a) 3-amino-4-deoxo-4-imino-rifamycin S,(b) 3-amino-4-deoxo-4-[(4-aminophenyl)sulfonyl]amino-rifamycin SV,(c) 4-O-(n-butylsulfonyl)-3-[(1-piperidinylimino)methyl]-rifamycin SV,(d) 4-O-(n-butylsulfonyl)-3-[(4-morpholinylimino)methyl]-rifamycin SV,(e) 3-[(dimethylhydrazono)methyl]-4-O-[(3-phenylpropyl)sulfonyl]-rifamycin SV, and(f) 4-deoxo-N,3-ethylidenimino-4-(methylsulfonyl)amino-rifamycin SV, said amount being effective to alleviate the effects of said hepatitis B virus. Also disclosed is a method of inhibiting the viral polymerase of hepatitis B virus by subjecting said polymerase to an amount of one of the rifamycin derivatives (a)-(f) above, said amount being effective to prevent the synthesis of hepatitis B virus by said viral polymerase.Type: GrantFiled: August 25, 1986Date of Patent: May 10, 1988Assignee: American Home Products CorporationInventor: Paul P. Hung
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Patent number: 4631290Abstract: The invention disclosed herein provides a method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected from a group consisting of(a) 3-amino-4-deoxo-4-imino-rifamycin S,(b) 3-amino-4-deoxo-4-[(4-aminophenyl)sulphonyl]amino-rifamycin SV,(c) 4-O-n-butylsulphonyl-3-[(1-piperidinylimino)methyl]-rifamycin SV,(d) 4-O-n-butylsulfonyl-3-[(4-morpholinylimino)methyl]-rifamycin SV,(e) 3-[(dimethylhydrazono)methyl]-4-O-[(3-phenylpropyl)sulfonyl]-rifamycin SV said amount being effective to alleviate the effects of said hepatitis B virus. Also disclosed is a method of inhibiting the viral polymerase of hepatitis B virus by subjecting said polymerase to an amount of one of the rifamycin derivatives (a)-(e) above, said amount being effective to prevent the synthesis of hepatitis B virus by said viral polymerase.Type: GrantFiled: August 29, 1985Date of Patent: December 23, 1986Assignee: American Home Products CorporationInventor: Paul P. Hung
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Patent number: 4558010Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.Type: GrantFiled: September 7, 1982Date of Patent: December 10, 1985Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Shaw-Guang Lee, Ranajit Roychoudhury, Barry J. Ratzkin
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Patent number: 4370417Abstract: The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.Type: GrantFiled: April 3, 1980Date of Patent: January 25, 1983Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Shaw-Guang Lee, Ranajit Roychoudhury, Barry J. Ratzkin, W. Jurgen Schrenk, Michael C. Chen
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Patent number: 4331589Abstract: Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.Type: GrantFiled: April 16, 1981Date of Patent: May 25, 1982Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Shaw-Guang Lee
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Patent number: 4326033Abstract: Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.Type: GrantFiled: May 5, 1980Date of Patent: April 20, 1982Assignee: Abbott LaboratoriesInventors: William H. Holleman, Shaw-Guang Lee, Paul P. Hung
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Patent number: 4224408Abstract: Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.Type: GrantFiled: November 22, 1978Date of Patent: September 23, 1980Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Shaw-guang Lee
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Patent number: 3979511Abstract: A method of inhibiting the activity of reverse transcriptase in Rous sarcoma viruses and other viruses containing reverse transcriptase. The method comprises subjecting the reverse transcriptase to an enzyme inhibiting effective dosage of a compound of the formula: ##SPC1##Wherein R' is hydrogen or hydroxyl and R is C.sub.1 -C.sub.8 alkyl, cyclohexyl, phenyl, benzyl, and substituted benzyl.Type: GrantFiled: May 23, 1974Date of Patent: September 7, 1976Assignee: Abbott LaboratoriesInventors: Paul P. Hung, Nathan L. Shipkowitz, Anne Mary Von Esch