Patents by Inventor Paul R. Mueller

Paul R. Mueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engine-mounted fan shroud and seal
    Patent number: 8303244
    Abstract: The invention concerns an engine-mounted fan shroud for use in a vehicle that has a shroud body supported by a vehicle engine, including an outer ring made of a first material having a first stiffness, and a bodyside seal extending from and being integral with the outer ring, with the bodyside seal being made of a second material having a second stiffness that is less than the first stiffness. The bodyside seal fits into and seals around a seal opening in a body-mounted shroud that is mounted to radiator support structure.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: November 6, 2012
    Assignee: GM Global Technology Operations LLC
    Inventors: Joseph H. Alexander, Jeffrey R. Tatrow, Paul R. Mueller
  • Method for identifying a reagent that modulates Myt1 activity
    Patent number: 6387642
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: May 14, 2002
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy
  • METHOD FOR IDENTIFYING A REAGENT THAT MODULATES MYT1 ACTIVITY
    Publication number: 20020016444
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Application
    Filed: April 30, 2001
    Publication date: February 7, 2002
    Applicant: California Institute of Technology, a California corporation
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko kumagai, William G. Dunphy
  • Isolated Myt1 polypeptide
    Patent number: 6225101
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: May 1, 2001
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy
  • DNA encoding a Myt1 polypeptide
    Patent number: 6020194
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: February 1, 2000
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy
  • Method of preparing nucleic acids having an undefined nucleotide sequence amplification
    Patent number: 5599696
    Abstract: A method for amplifying specific nucleic acid fragments having an undefined nucleotide sequence wherein said nucleic acid fragments are present in a mixture of nucleic acids. Blunt ended linkers with known nucleotide sequences are used in the method to isolate and distinguish the specific undefined nucleic acid fragments from the rest of the nucleic acid. Primers which hybridize with the known linker are then used as part of a polymerase chain reaction procedure to amplify the specific nucleic acid fragment which includes the undefined nucleotide sequence.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: February 4, 1997
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Paul A. Garrity, Barbara J. Wold