Abstract: The present invention provides pharmaceutical combinations comprising (a) a compound of formula (I) wherein R represents phenyl or pyridinyl; wherein phenyl is optionally substituted by one or two substituents independently selected from lower alkyl, lower alkoxy, hydroxyl, amino, lower alkylamino, lower dialkylamino, acetylamino, halogen and nitro; and wherein pyridinyl is optionally substituted by amino or halogen; R1 represents hydrogen or cyano-lower alkyl; and wherein the prefix lower denotes a radical having up to and including a maximum of 4 carbon atoms; or a pharmaceutically acceptable derivative thereof; and (b) a CD40 agonist.

Abstract: A light therapy system and method are provided for treating humans or terrestrial or aquatic animal and plant subjects with non-coherent light. The system includes an electrical controller configured with two supplies of voltage, high and low frequency pulse-width-modulators, adjustable high and low frequency duty cycle controllers for controlling the duty cycle outputs of the respective high and low frequency pulse-width-modulators that determine light pulsation intensities, and at least one light source electrically connected to the electrical controller and having at least two distinct light emitting elements. One light emitting element operates at high light pulsation frequencies, and another light emitting element operates at low light pulsation frequencies. The light may include a plurality of the high frequency powered light emitting elements and a plurality of the low frequency powered light emitting elements.

Abstract: The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.

Abstract: The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.

Abstract: The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.

Abstract: A mount for supporting a cargo carrier to a vehicle having a standard receiver hitch, comprises a receiver bar adapted for connecting with the receiver hitch, and first and second plate members generally vertically disposed and affixed to the receiver bar. The plate members have, at least over a portion thereof, substantially planar surfaces for adjacent abutment thereof. A rigid member such as a crosspiece, yoke, or bracket, is affixed to the outermost plate member, and a carrier supported by the rigid member is cantilevered from the mount.

Abstract: A carrier assembly for a vehicle having a standard receiver hitch, comprising a receiver bar for connecting the carrier with the receiver hitch, and a plate member depends from and is disposed transversely to the receiver bar. The plate member has a substantially planar facing disposed outwardly from the receiver bar. A retaining member such as a cross-bar or yoke is affixed to the planar facing of said plate member. A generally horizontally disposed platform depends from the support member useful for supporting and transporting a load.

Abstract: A decorative, lightweight, sound absorbent, fire resistant, space-dividing wall panel for use in open office systems which includes a foamed in-place gypsum core surrounded by a metal frame and a uniform cover material covering the foam sides and substantial portion of the metal frame. The cover material is preferably a polyurethane-backed fabric and may include a relief design of a preselected geometric pattern therein.