Abstract: A method for manufacturing an implant can include receiving at a computing device, patient specific data related to a bone of a patient and implant data related to an implant for the patient, and determining, by the computing device, optimal design parameters for the implant for the patient using the patient specific data and a machine learning model. The method can also include exporting, by the computing device, the optimal design parameters to a manufacturing device of systems for manufacturing the implant. The optimal design parameters can provide for a non-solid implant construction in regions of lower stress within the bone of the patient and a solid implant construction in regions for higher stress within the bone of the patient to bring stress distributions closer to those experienced in a non-implanted bone to, in turn, reduce the likelihood of bone resorption and peri-prosthetic fractures after implantation of the implant.

Abstract: A rotatable nacelle includes an engine inlet configured to receive air and an inlet air management system (IAMS). The IAMS includes a primary inlet configured to selectively allow air to flow into a duct associated with the engine air inlet via the primary inlet and a secondary inlet configured to selectively allow air to flow into the duct associated with the engine air inlet via the secondary inlet. The secondary inlet is configured to receive an air filter.

Abstract: Orthopedic instalments for removing bone including along an intramedullary canal and methods of their fabrication are disclosed. In one example, the orthopedic instrument can include a body having an exterior surface and can define an interior cavity. The body can have a plurality of channels communicating with the interior cavity from the exterior surface.

Abstract: Various embodiments discussed in the present document relate to an implant assembly. The implant assembly includes a porous metal coating. The implant assembly further includes a biocompatible implant material. A polymeric binder layer is disposed between the porous metal coating and the biocompatible implant material.

Abstract: Upholstery tufting apparatus comprises an insertion needle (5) with an aperture (4) to receive a tuft for insertion into an article to be upholstered. The tuft is presented to the needle aperture (4) along a tuft feed axis (3). The apparatus has a plurality of tuft strings (2a, 2b, 2c), a first string (2a) with tufts of a first length and a second string (2b) with tufts of different second length. The apparatus has one or more tuft feed units, and an actuator operatively connected to said tuft feed unit(s). The first and second tuft strings (2a, 2b) are associated with the tuft feed unit(s). A selected one of the tuft feed unit(s) is actuatable by the actuator to align one of the first and second strings (2a, 2b) with the tuft feed axis (3) according to the length of tuft required to be inserted into an article to be upholstered. A method for tufting an upholstered article employing said apparatus is also described.

Abstract: An implant can be implantable into a human body and can include a metallic substrate and a ceramic layer. The metallic substrate can be formed by additive manufacturing. The metallic substrate can be engageable with a bone. The metallic substrate can include an inner surface, an outer surface, and a plurality of retention features. The inner surface can define a plurality of pores configured to promote bone ingrowth into the metallic substrate. The plurality of retention features can include a proximal portion connected to the outer surface and the proximal portion can define a proximal width. The ceramic layer can be a bearing surface that can be spray coated to the metallic substrate and formed around the retention features to interlock the ceramic layer with the metallic substrate.

Abstract: A method of connecting two CMC substrates that includes providing two substrates; placing one substrate approximate to the other substrate, such that at least a portion of the two substrates overlap and define a brazing area; placing a brazing material approximate the brazing area; defining a primary raster pattern that encompasses the brazing area and a portion of the two substrates outside the brazing area; defining a secondary raster pattern that encompasses the brazing area; allowing a laser to scan the primary raster pattern to preheat the brazing area to a temperature below the brazing material's melting point; allowing the laser to scan the secondary raster pattern to heat the brazing area to a temperature that is above the brazing material's melting point; melting and allowing the brazing material to flow within the brazing area; and cooling the brazing area to form a brazed joint connecting the two substrates.

Abstract: Metal working fluid decontamination apparatus (10) includes: an intake arrangement (40) for metal working fluid (42); a pump (16) for providing, in use, flow pressure to the metal working fluid (42); a decontaminator (50) for reducing contamination in the metal working fluid (42); and an outlet arrangement (34) for the metal working fluid. The metal working fluid (42) is a fully synthetic metal working fluid, which comprises water and a water soluble synthetic concentrate which does not comprise oil.

Abstract: Various embodiments discussed in the present document relate to an implant assembly. The implant assembly includes a porous metal coating. The implant assembly further includes a biocompatible implant material. A polymeric binder layer is disposed between the porous metal coating and the biocompatible implant material.

Abstract: A method of connecting two CMC substrates that includes providing two substrates; placing one substrate approximate to the other substrate, such that at least a portion of the two substrates overlap and define a brazing area; placing a brazing material approximate the brazing area; defining a primary raster pattern that encompasses the brazing area and a portion of the two substrates outside the brazing area; defining a secondary raster pattern that encompasses the brazing area; allowing a laser to scan the primary raster pattern to preheat the brazing area to a temperature below the brazing material's melting point; allowing the laser to scan the secondary raster pattern to heat the brazing area to a temperature that is above the brazing material's melting point; melting and allowing the brazing material to flow within the brazing area; and cooling the brazing area to form a brazed joint connecting the two substrates.

Abstract: Upholstery tufting apparatus comprises an insertion needle (5) with an aperture (4) to receive a tuft for insertion into an article to be upholstered. The tuft is presented to the needle aperture (4) along a tuft feed axis (3). The apparatus has a plurality of tuft strings (2a, 2b, 2c), a first string (2a) with tufts of a first length and a second string (2b) with tufts of different second length. The apparatus has one or more tuft feed units, and an actuator operatively connected to said tuft feed unit(s). The first and second tuft strings (2a, 2b) are associated with the tuft feed unit(s). A selected one of the tuft feed unit(s) is actuatable by the actuator to align one of the first and second strings (2a, 2b) with the tuft feed axis (3) according to the length of tuft required to be inserted into an article to be upholstered. A method for tufting an upholstered article employing said apparatus is also described.

Abstract: The invention relates to biomarkers for predicting whether a patient infected with Hepatitis B virus (HBV) will respond to interferon (IFN) therapy. The invention also relates to methods and kits for predicting whether a patient will respond to IFN therapy using said biomarkers.

Abstract: A personal vehicle system including a deck having a substantially flat top surface, where the top surface is substantially flat and is of sufficient area to support two feet of a user, a truck coupled to the deck, where the truck consist of a first portion coupled to the deck and a second portion that tilts relative to the first portion, and a wheel motor coupled to the second portion of the truck. A personal vehicle system that includes a deck, a truck coupled to the deck, and a wheel motor coupled to the truck, where the wheel motor has a passive cooling system. The passive cooling system includes at least one endcap that rotates about a wheel rotation axis during operation of the wheel motor and the endcap has at least one fin.

Abstract: Apparatus and methods for use in the manufacture of a spring unit for incorporation into an upholstered article, for example, a mattress, cushion or the like. Coil formation apparatus includes a drive shaft to control movement of a coil pitch guide member and a link member comprising a connecting rod adjustably connected to a radius arm of the drive shaft. A coil interlinking process comprises compressing a first coil to define a clearance, extending a second coil passed the first coil via the clearance, allowing the first coil to extend across the clearance, and contracting the second coil to engage the first coil thereby interlinking the first and second coils. Spring unit manufacturing apparatus comprises a plurality of jaw pairs each comprising a first fixed jaw and a pivotal second jaw, the pivotal second jaw being pivoted by a cam and linkage assembly operated by a rotary drive shaft.

Abstract: Apparatus and methods for use in the manufacture of a spring unit for incorporation into an upholstered article, for example, a mattress, cushion or the like. Coil formation apparatus includes a drive shaft to control movement of a coil pitch guide member and a link member comprising a connecting rod adjustably connected to a radius arm of the drive shaft. A coil interlinking process comprises compressing a first coil to define a clearance, extending a second coil passed the first coil via the clearance, allowing the first coil to extend across the clearance, and contracting the second coil to engage the first coil thereby interlinking the first and second coils. Spring unit manufacturing apparatus comprises a plurality of jaw pairs each comprising a first fixed jaw and a pivotal second jaw, the pivotal second jaw being pivoted by a cam and linkage assembly operated by a rotary drive shaft.

Abstract: Apparatus and methods for use in the manufacture of a spring unit for incorporation into an upholstered article, for example, a mattress, cushion or the like. Coil formation apparatus includes a drive shaft used to control movement of a coil pitch guide member and a link member comprising a connecting rod connected to a radius arm of the drive shaft by means of an adjustable connection. A coil interlinking process comprises compressing a first coil to define a clearance extending a second coil passed the first coil via the clearance, allowing the first coil to extend across the clearance, and contracting the second coil such that the second coil engages the first coil thereby interlinking the first and second coils. Spring unit manufacturing apparatus comprises a plurality of jaw pairs each comprising a first fixed jaw and a pivotal second jaw, the pivotal second jaw being pivoted by a cam and linkage assembly that is operated by a rotary drive shaft.

Abstract: Apparatus and methods for use in the manufacture of a spring unit for incorporation into an upholstered article, for example, a mattress, cushion or the like. Coil formation apparatus includes a drive shaft used to control movement of a coil pitch guide member and a link member comprising a connecting rod connected to a radius arm of the drive shaft by means of an adjustable connection. A coil interlinking process comprises compressing a first coil to define a clearance extending a second coil passed the first coil via the clearance, allowing the first coil to extend across the clearance, and contracting the second coil such that the second coil engages the first coil thereby interlinking the first and second coils. Spring unit manufacturing apparatus comprises a plurality of jaw pairs each comprising a first fixed jaw and a pivotal second jaw, the pivotal second jaw being pivoted by a cam and linkage assembly that is operated by a rotary drive shaft.

Abstract: The present invention relates to a method and apparatus for the automatic insertion of an individual upholstery tuft (3) and washer (1) from a plurality of connected tufts (4) and a plurality of connected washers (2) into an upholstered article. The apparatus has a cutting blade (35) to separate an individual tuft (3) from the plurality of connected tufts (4). The turf (3) is then engaged by a pair of arms (27, 28) and fed into a tuft insertion needle (14). The arms are connected to automatic washer feed apparatus which feeds an individual washer (1) from the plurality of connected washers (2) and aligns it with the tuft insertion needle (14) ready for insertion. The insertion needle (14) is pneumatically actuated to force the tuft (3) through the washer (1), into the upholstered article, release the tuft (3) and subsequently withdraw the needle (14) from the article.

Abstract: A circuit for supplying selected currents to a charge pump without harmful effects arising from operation of current switches in the charge pump. A charge pump current setting is applied in digital form to a set of two-position switches coupled to binary-weighted current sources. Currents from the sources selected by the switches are combined, and the total current is mirrored to the charge pump. Simultaneously, those of the binary-weighted current sources not selected by the switches to contribute to the charge pump current are separately combined, and this total current is mirrored to an electrical replica of the charge pump. Thus the currents supplied to the charge pump and to the replica charge pump are complementary in the sense that they always add to a constant total current drawn from a common power supply. Therefore, abrupt changes in current load are avoided and switching noise effects are minimized.

Abstract: A circuit and corresponding method for doubling the frequency of an input signal, even when the input signal is of low frequency or a square wave. The input signal is applied to a phase-shifting circuit that produces a pair of output signals that are theoretically 90° apart in phase, but may lack the desired form if the original input signal is of low frequency. The waveforms of the two output signals are enhanced in latching hysteresis buffers that produce more uniformly squared waves, with zero crossings corrected to be more exactly 90° apart and with desirably steep state transitions. The enhanced-waveform output signals are coupled to an exclusive OR (XOR) gate to produce a double-frequency output.