Abstract: The compositions disclosed herein are of use for the treatment of a wide variety of diseases. In particular, the compositions provide oxytocin and oxytocin analogs in sustained release formulations. In particular embodiments, the disclosed compositions concern oxytocin and oxytocin analogs, each of which may be associated with a biodegradable polymer and/or attached to a hydrophilic polymer. The methods include treatment of a wide variety of diseases and conditions. In particular, the methods include treatment of sexual dysfunction and disorders associated with repetitive behaviors, such as autism. The usefulness of the present invention is that the oxytocin, oxytocin analogs and mixtures thereof can be administered in a pharmaceutical formulation that increases their half-life and also provides for sustained release.

Abstract: Methods and systems for use of member-to-member, member-to-target and automatically generated coaching messages in a closed communication service are provided. According to one embodiment, a closed communication service is provided which is configured to facilitate and encourage communications among members of a caregroup and a target of the caregroup. The target of the caregroup uses a hardcopy-based communication appliance associated with the caregroup to transmit and receive electronic communications via the closed communication service to and from the members of the caregroup. Identification, creation and delivery of appropriate member-to-member and member-to-target coaching messages are facilitated by allowing one or more administrating caregivers of the members of the caregroup to view metrics relating to electronic communications exchanged via the closed communication service.

Abstract: Methods and systems for analysis of aggregate data from multiple caregroups participating in a closed communication service are provided. According to one embodiment, a closed communication service is provided that is configured to facilitate and encourage communications among members of caregroups and targets of the caregroups. The targets of the caregroups use communication appliances associated with respective caregroups to transmit and receive electronic communications via the closed communication service to and from members of the respective caregroups. Data relating to the electronic communications is collected and aggregated. Diagnosis of subpopulations of disease or disability and evaluation or discovery of new methods of diagnosis or intervention strategies to slow, ameliorate, prevent or remediate a condition including one or more of a chronic condition in elders, a disability, a disease and a mental or physical condition is facilitated by analyzing the collected and aggregated data.

Abstract: Methods and systems for improving the well-being or reducing stress of a primary caregiver of an elder subject are provided. According to one embodiment, a communications network provides a closed communication service. A database is operable to store information regarding caregroup membership. One or more server computers coupled to the database are operable to receive from and distribute electronic communications among electronic communication access systems associated with members of a caregroup and a communication appliance associated with a target of the caregroup. The one or more server computers have stored therein one or more routines operable to facilitate and encourage one or more of affective communication, activity stimulating communication and intellectually stimulating communication among the members of the caregroup and the target of the caregroup as a method of improving well-being or reducing stress of a primary, residential caregiver of the target.