Patents by Inventor Paul Stanislaw Siedlecki

Paul Stanislaw Siedlecki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of nitrogen mustard derivatives
    Patent number: 6737541
    Abstract: This invention relates to an improved synthesis of 5-(N-[(S)-N-{N,N-bis( 2-chloroethyl)amino}phenoxycarbonyl)-&ggr;-glutamyl]amino)isophthalic acid (also named ZD9063P), a prodrug used in Antibody Directed Enzyme Prodrug Therapy (ADEPT), a targeted cytotoxic cancer therapy. Another aspect of the invention comprises a compound of Formula (I) in which R1 and R2 are chloro, R3 is an alphamethylbenzylamine salt of carboxylic acid, (R4)n represents a benzyl protected 3,5-dicarboxylic acid and the asterisked chiral carbon in Formula (I) has S configuration, preferably in crystalline form.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: May 18, 2004
    Assignee: AstraZeneca AB
    Inventors: Paul Stanislaw Siedlecki, David Michael Glanville Martin
  • Preparation of nitrogen mustard derivatives
    Publication number: 20030162990
    Abstract: 1
    Type: Application
    Filed: November 19, 2002
    Publication date: August 28, 2003
    Inventors: Paul Stanislaw Siedlecki, David Michael Glanville Martin