Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: A method and system for providing travel information to a consumer are disclosed. The method and system may include identifying one or more potential information sources using a content identification segment (CIS). Further, the method and system may include acquiring information from at least one information source, which may be a variety of sources such as external or consumer-driven sources; characterizing the acquired information by its pertinence to travel; transforming the characterized travel information into a useable format; applying rules to this transformed travel information in connection with the consumer-specific travel profile; and, delivering a report to the consumer of the results of this application. Finally, an information system segment may be provided that may include a collection subsystem, and analysis subsystem, and a distribution subsystem.

Abstract: A method and system for providing travel information to a consumer are disclosed. The method includes acquiring information from at least one information source, which may be a variety of sources such as external or consumer-driven sources; characterizing the acquired information by its pertinence to travel; transforming the characterized travel information into a useable format; applying rules to this transformed travel information in connection with the consumer-specific travel profile; and, delivering a report to the consumer of the results of this application. The associated system performs these functions, among others, to provide information for a traveler planning a trip to a particular destination or destinations.