Patents by Inventor Paul Thornalley

Paul Thornalley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF ALPHA, BETA-DICARBONYL COMPOUNDS WITH FLUOROGENIC PROBES
    Publication number: 20160178637
    Abstract: The disclosure relates to a fluorescence based assay for the detection of alpha, beta-dicarbonyl containing compounds, for example alpha-oxoaldehyde compounds such as glyoxal, methylglyoxal, hydroxypyruvaldehyde, erythrosone, 3-deoxy-erythrosone, ribosone, 3-deoxyribosone, glucosone, 3-deoxyglucosone and stereoisomers thereof and butan-2,3-dione that uses a fluorogenic probe which is stable under ambient conditions. The fluorogenic probes comprise a 1,2-diaminophenyl moiety. The diaminophenyl probes yield a 20-fold increase in quantum yield when they are a derivative of fluorescein (DAF), rhodamine (DAR), BODIPY or cyanine. The assay is preferably carried out at pH 4-8. Corresponding screening methods for modulators of alpha, beta-dicarbonyl compound concentrations are also disclosed.
    Type: Application
    Filed: August 9, 2013
    Publication date: June 23, 2016
    Inventors: Paul Thornalley, Naila Rabbani
  • Prevention of proteomic and genomic damage by dicarbonyl substrates of Glo 1
    Patent number: 9351951
    Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: May 31, 2016
    Assignee: University of Warnick
    Inventors: Mingzhan Xue, Paul Thornalley, Naila Rabbani
  • PREVENTION OF PROTEOMIC AND GENOMIC DAMAGE BY DICARBONYL SUBSTRATES OF GLO 1
    Publication number: 20130231387
    Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
    Type: Application
    Filed: June 20, 2011
    Publication date: September 5, 2013
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: Mingzhan Xue, Paul Thornalley, Naila Rabbani