Abstract: A catheter system having one or more needle position indicators to assist an operator in withdrawing the introducer needle to a “parked” position, as part of a catheterization procedure, wherein the needle position indicator provides a visual indication to the operator.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: A power meter for measuring power usage in a circuit includes preprocessor and a weighting network. The pre-processor is configured to receive toggle data for a number of power proxy signals in the circuit for a plurality of clock cycles of the circuit in a first time window. The power proxy signals and weighting values are determined automatically from simulated or emulated toggle data. For each power proxy signal, the pre-processor averages the toggle data over one or more clock cycles in one or more second time windows, within the first time window, to provide averaged toggle data, and outputs the averaged toggle data for each second time window. The weighting network is configured to combine the averaged toggle data from the power proxy signals, based on a set of weight values, to provide a measure of the power usage.

Abstract: Example flap actuation systems and related methods are disclosed herein. An example control surface actuation system includes processor circuitry to cause a first actuator to generate an output to operatively couple the first actuator to a first drive arm; cause a second actuator to generate an output to operatively couple the second actuator to a second drive arm; cause the first actuator and the second actuator to move a control surface when the first actuator and the second actuator are in an operative state; detect the first actuator as in a failed state; and in response to the first actuator being in the failed state, cause first actuator to refrain from generating the output to disrupt the operative coupling between the first actuator and the first drive arm; and cause the second actuator to move the control surface via the first drive arm and the second drive arm.

Abstract: Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: A switched-capacitor DC-DC converter circuit may convert an input voltage into a desired output voltage level. A comparator may compare a desired voltage level to a divided version of the output voltage. A fully digital control circuit comprising a frequency divider circuit, a counter circuit, a digital control logic circuit and a gain selection circuit may generate a gain value, and a phase generator may convert the gain value into clock phase signals and control settings to control a switch array to select capacitors to produce a desired output voltage.

Abstract: A wellbore anchoring device having an adjustable injection valve is disclosed. The anchoring device can include the adjustable injection valve and a spring. The spring can be positioned adjacent to the adjustable injection valve. The spring can include an initial pressure setting that is adjustable prior to the anchoring device being positioned in a wellbore to adjust a cracking pressure of the adjustable injection valve.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: A method and apparatus for forming a sensor within a subsea node using additive manufacturing.

Abstract: A first node can be selected as a target node, and a second node can be selected as a control to determine a performance limit associated with providing a service. A request for the service can be determined to be routed to the first node. A first indication of a first performance measurement associated with processing a first load by the first node can be received. A second indication of a second performance measurement associated with processing a second load by the second node can be received. A performance error of the first node can be determined based on the first performance measurement and the second performance measurement. The performance limit can be determined based on the performance error, and an action can be triggered based on the performance limit.

Abstract: The present disclosure is directed to security settlement in financial markets and cryptographic currencies. Particular portions of the present disclosure are directed to a cryptographic currency protocol and to a cryptographic currency that includes a positional item. The cryptographic currency protocol supports a virtual wallet that, in various embodiments, is a security and cash account for storing and managing the cryptographic currency. Opening a transaction via the virtual wallet to transfer the cryptographic currency is a strong guarantee of the availability of funds in the virtual wallet because, e.g., funds are not transacted unless the commit phase is successful.

Abstract: A subassembly for a shaving razor cartridge with a base having a front wall with a top surface and a rear wall with a top surface. At least one blade is mounted to the base between the front wall and the rear wall. The at least one blade has a cutting edge positioned at least 0.5 mm below a plane tangent to the top surface of the front wall and the top surface of the rear wall.

Abstract: A subassembly for a shaving razor cartridge with a base having a front wall with a top surface and a rear wall with a top surface. At least one blade is mounted to the base between the front wall and the rear wall. The at least one blade has a cutting edge positioned at least 0.5 mm above a plane tangent to the top surface of the front wall and the top surface of the rear wall.

Abstract: Methods including precipitated and mined calcium carbonate lost circulation materials for use in subterranean formation operations. The precipitated calcium carbonate lost circulation materials are formed under a chosen set of precipitation conditions, including in situ in a subterranean formation. The mined calcium carbonate lost circulation materials are obtained in a desired morphological form under naturally occurring mined conditions. The precipitated and mined calcium carbonate lost circulation materials may be needle-shaped aragonite having an aspect ratio of about 1.4 to about 15.

Abstract: A shaving cartridge with a housing having a primary guard and a secondary cap. A bridge member is integrally molded with the housing. The bridge member has a plurality of spaced apart parallel ribs. The plurality of spaced part ribs define a primary cap surface and a secondary guard surface. A first blade having a cutting edge is mounted to the housing between the primary guard and the primary cap surface. A second blade having a cutting edge extending in a same direction as the cutting edge of the first blade is mounted to the housing between the secondary guard surface and the secondary cap. The cutting edge of the first blade and the cutting edge of the second blade define an interblade span greater than 3.0 mm. The plurality of spaced apart parallel ribs define a plurality of rinse openings extending thru the bridge member.

Abstract: Example flap actuation systems and related methods are disclosed herein. An example control surface actuation system includes processor circuitry to cause a first actuator to generate an output to operatively couple the first actuator to a first drive arm; cause a second actuator to generate an output to operatively couple the second actuator to a second drive arm; cause the first actuator and the second actuator to move a control surface when the first actuator and the second actuator are in an operative state; detect the first actuator as in a failed state; and in response to the first actuator being in the failed state, cause first actuator to refrain from generating the output to disrupt the operative coupling between the first actuator and the first drive arm; and cause the second actuator to move the control surface via the first drive arm and the second drive arm.

Abstract: A shaving razor cartridge having a housing with a primary guard and a secondary cap. A bridge member is integrally molded as part of the housing. A plurality of spaced apart parallel ribs of the bridge member extend transverse to the cutting edge of the first blade. The plurality of spaced part ribs define a primary cap surface and a secondary guard surface. A first blade mounted to the housing between the primary guard and the primary cap surface. A second blade having a cutting edge extends in a same direction as the cutting edge of the first blade and is mounted to the housing between the secondary guard surface and the secondary cap. The plurality of spaced apart parallel ribs define a plurality of rinse openings extending thru the bridge member.

Abstract: A smart obturator assembly includes a hub forming a central passage. The hub is configured to couple to a proximal end of a device that forms a lumen such that the central passage is in fluid communication with the lumen. A collar on the hub includes electronic circuitry in signal communication with remote reception circuitry. An obturator is movably positionable within the lumen. The obturator is movable within the lumen between a first position and a second position. The obturator includes a distal end and a sensor at the distal end. The sensor is configured to sense an environmental characteristic within a patient’s blood stream, generate a signal representative of the environmental characteristic, and transmit the signal to the electronic circuitry. The electronic circuitry is configured to receive the signal and transmit the signal to the remote reception circuitry.

Abstract: An obturator assembly includes an obturator positionable within a lumen of a device and movable within the lumen between a first position and a second position. The obturator includes a distal tip portion, wherein, with the obturator in the first position, the distal tip portion limits fluid communication through the lumen and, with the obturator in the second position, the distal tip portion provides fluid communication through the lumen.