Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS 1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Abstract: In a method for automatically directing traffic on a site, information is received regarding a plurality of selected entities on the job site. An indication of a first priority assigned to a first of the plurality of selected entities is received. An indication of a second priority assigned to a second of the plurality of selected entities is received. It is then determined that the first of the plurality of selected entities has a right of way over the second of the plurality of selected entities based upon a comparison of the first priority and the second priority.

Abstract: Methods and systems for integrated asset management are disclosed. According to one embodiment, information from a first reporting source about an asset is received. In addition, information is received about the asset from a second reporting source. Inspection information about the asset is received from a first enabled device. A database is then populated with the information from the first reporting source, the information from the second reporting source, and the inspection information from the first enabled device, such that the information from the first reporting source, the information from the second reporting source, and the inspection information from the first enabled device can be collected or accessed in an integrated manner from the database for use by a client information system.

Abstract: A method for enabling notifications pertaining to an asset is disclosed. The method receives information from a first reporting source about an asset. In addition, information from a second reporting source about the asset is also received. A database is then populated with the information from the first reporting source and the information from the second reporting source such that information from the first reporting source and information from the second reporting source can be accessed from the database. A state machine for the asset is maintained based on the received information which enables providing notifications pertaining to the asset.

Abstract: A method and system for utilizing historical data in an asset management environment are disclosed. According to one embodiment, a method generates an asset information report from a database, wherein the asset information report comprises at least a portion of real-time information about the asset when the real-time information about the asset is available. In addition, the asset information report is augmented by extrapolating at least a portion of historical asset information stored at the database when at least a portion of the real-time information is not available.

Abstract: Non-multiple delay element values that may be implemented to reduce periodic quantization errors associated with phase shifting devices used in phased array apparatus. The non-multiple delay element values may be implemented so that a magnitude of phase shift imparted by a given delay element of a phase shifting scheme is not a multiple or a factor of the magnitude of the phase shift imparted by any other delay element employed in the same phase shifting scheme.

Abstract: A 99mcTc labeled metal transport protein, products and uses thereof in imaging and especially detecting the presence of high energy/iron uptake tissues such as a tumour within a mammalian body are provided.

Abstract: A 99mcTc labeled metal transport protein, products and uses thereof in imaging and especially detecting the presence of high energy/iron uptake tissues such as a tumour within a mammalian body are provided.

Abstract: A vertical take-off and landing vehicle comprised of a fuselage having a front, a rear, and two lateral sides and a set of four thrusters set to the front, the left, the right, and the rear of said fuselage. The thrusters are either independently powered thrusters or could utilize a single power source. The thrusters, which are ducted fan units capable of providing a vertically upward force to the aircraft, are provided with such redundancy that the aircraft can hover with up to two thrusters inoperative. The thrusters are comprised of a set of two counter rotating propellers both of which creates lift. The two counter rotating propellers cancel out the torque effect normally created by using only one propeller. The Ducted fan units being movable between a first position in which they provide vertical lift and a second position in which they provide horizontal thrust using a set of servos and gears.

Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge: in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor. Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.

Abstract: A method of radio-labelling a biomolecule comprising contacting the biomolecule with a source of radionuclide, such as technetium, in the presence of a weak transfer ligand and optionally subsequently passing the mixture through a size-exclusion filtration process. Also claimed are kits comprising such novel compositions, especially lactoferrin coupled to chemotherapeutic agents, and uses therefor.

Abstract: The present invention provides an electronically interactive educational and/or cognitive learning method and system in which electronically reproduced text and imagery may have portions thereof selected and automatically converted into notes and/or cues, annotations automatically inserted therein, dictionary definitions, thesaurus meanings, word etymology and language conversions displayed or automatically inserted therein for a learning reference or note guide with respect to the text or imagery.

Abstract: The invention relates to a 99mTc labelled metal transport protein, products and uses thereof in imaging and especially detecting the presence of high energy/iron uptake tissues such as a tumour within a mammalian body.