Patents by Inventor Paul Watt
Paul Watt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12001837Abstract: Disclosed are techniques for two-way synchronization of infrastructure-as-code templates and instances, including a method comprising detecting changes to a run-time state of a system and, in response to detecting a change, triggering an update of a current run-time state model. The method may further comprise, in response to updating the run-time state model, comparing the updated model to a current model using a template in a local repository instantiated as the current model. The method may further comprise, in response to the comparison determining a structural difference between the updated model and the current model, merging the updated model and the current model into a new model; and updating a local clone of a repository of the template with the new model. The method may further comprise, in response to the comparison determining no structural difference between the updated model and the current model, pushing changes to a remote repository.Type: GrantFiled: March 18, 2022Date of Patent: June 4, 2024Assignee: International Business Machines CorporationInventors: Joseph Paul Wigglesworth, Miguel Angel Jimenez Achinte, Gabriel Tamura, Hans Albert Muller, Ian Fraser Watts, Hugh Edward Hockett
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Publication number: 20240171326Abstract: A method and apparatus for performing a channel access procedure and transmitting a set of repetitions is disclosed. A wireless transmit/receive unit (WTRU) may be configured to receive information to transmit uplink data. The information may indicate a first number of nominal repetitions and a first number of symbols for each of the first number of nominal repetitions. The WTRU may be configured to determine a set of symbols associated with a first nominal repetition and to transmit a second number of actual repetitions in symbols associated with the first nominal repetition. The second number of actual repetitions and the symbols used to transmit the second number of actual repetitions may be based on an occurrence of an event during the set of symbols associated with the first nominal repetition. The set of symbols associated with the first nominal repetition may comprise one or more subsets of consecutive uplink symbols.Type: ApplicationFiled: March 28, 2022Publication date: May 23, 2024Applicant: INTERDIGITAL PATENT HOLDINGS, INC.Inventors: Patrick Tooher, Faris Alfarhan, Dylan Watts, Paul Marinier
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Patent number: 11939321Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: GrantFiled: April 7, 2021Date of Patent: March 26, 2024Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio Berdini, Ildiko Maria Buck, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, Christopher William Murray, David Norton, Marc O'Reilly, Alison Jo-Anne Woolford, Michael Liam Cooke, David Cousin, Stuart Thomas Onions, Jonathan Martin Shannon, John Paul Watts
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Publication number: 20240071206Abstract: Systems, apparatuses, and methods are described for monitoring objects. A sensor positioned on an object (e.g., a door) is configured to measure a strength of a magnetic field of a magnet positioned on an associated object (e.g., the door frame). The measurements of the strength of the magnetic field made by the sensor may change over time (e.g., may decrease) due to changes in the positioning or alignment of the sensor or magnet. The positioning or alignment of the sensor or magnet may change due to use of the object (e.g., use of the door). One or more thresholds used by the sensor to determine the status of an object (e.g., to determine whether the door is open or closed) may be adjusted based on changes to the measurements over time.Type: ApplicationFiled: August 29, 2022Publication date: February 29, 2024Inventors: Lewis Dearman, Paul De La Rosa, Darrell Fuquay, Jon Watt
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Publication number: 20230408536Abstract: An automated analyser for high-throughput assay testing for the presence of a biological or biochemical substance includes a plurality of sample process stations to receive analysis vessels and perform one or more processing or analysis steps on samples retained in the analysis vessels and including at least an incubation station to receive a plurality of the analysis vessels, provide illumination to each sample of each analysis vessel in the incubation field, and maintain the plurality of analysis vessels at predetermined incubation temperatures. The analyser includes an analysis vessel transfer system to transfer analysis vessels between the process stations, an imaging system to image illuminated samples in the analysis vessels retained in the incubation field, and a resource controller.Type: ApplicationFiled: October 15, 2021Publication date: December 21, 2023Inventors: Paul OSTERGAARD, Paul WATT
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Publication number: 20230278989Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.Type: ApplicationFiled: January 25, 2023Publication date: September 7, 2023Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Steven HOWARD, Benjamin David CONS, Jeffrey David ST. DENIS, Charlotte Mary GRIFFITHS-JONES, Steven Douglas HISCOCK, Rhian Sara HOLVEY, Alan Richard BURNS, David COUSIN, Hannah Louise DEXTER, Guillaume François PARRA, John Paul WATTS, Robert JEWELL, Jennifer Ann STOCKWELL, Kim Louise HIRST, Isabelle Anne LEMASSON, David John NASH, James Daniel OSBORNE, Jonas Calleja PRIEDE, Nicholas Paul RICHARDS, Aaron Michael DUMAS, Brian Christopher BISHOP, David PARRY-JONES, Jeremy Peter SCOTT, Meenakshi Sundaram SHANMUGHAM, Peter Richard MULLENS, David Charles LATHBURY, Darren James DIXON, Matthew James GAUNT
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Publication number: 20230145050Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: October 17, 2022Publication date: May 11, 2023Inventors: David HARRISON, Alan Paul WATT, Mark G. BOCK
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Publication number: 20230142405Abstract: A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.Type: ApplicationFiled: April 23, 2020Publication date: May 11, 2023Applicant: NELSON MANDELA UNIVERSITYInventors: Paul WATTS, Ruvimbo MANGWIRO
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Publication number: 20230019032Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: ApplicationFiled: April 7, 2021Publication date: January 19, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio BERDINI, Ildiko Maria BUCK, James Edward Harvey DAY, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, Christopher William MURRAY, David NORTON, Marc O'REILLY, Alison Jo-Anne WOOLFORD, Michael Liam COOKE, David COUSIN, Stuart Thomas ONIONS, Jonathan Martin SHANNON, John Paul WATTS
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Patent number: 11518757Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: December 18, 2018Date of Patent: December 6, 2022Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Mark G. Bock
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Publication number: 20220330353Abstract: A system (1600) and method (960) for utilizing data from on-vehicle and off-vehicle sources to identify problematic devices and to execute automated mitigations is disclosed herein. The system (1620) comprises assigning authority engine (1105) for a vehicle (1000), a device (110) for the vehicle (1000), one or more databases (1615), and more or more cloud sources (1175). The assigning authority engine (1105) is configured to analyze the data based on a plurality of pre-defined patterns to identify a malfunctioning device and to transmit a mitigation strategy for the malfunctioning device.Type: ApplicationFiled: April 11, 2022Publication date: October 13, 2022Applicant: Platform Science, Inc.Inventors: Rio Jeane Abella, Scott Kopchinsky, Don Son, Paul Watts, Kevin O'Neil, Neth Maison
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Patent number: 11345669Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: March 12, 2018Date of Patent: May 31, 2022Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Nicolas Boutard, Charles-Henry Fabritius, Michal Galezowski, Piotr Kowalczyk, Oleksandr Levenets, Jakub Woyciechowski
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Publication number: 20220144756Abstract: This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.Type: ApplicationFiled: February 28, 2020Publication date: May 12, 2022Applicant: Nelson Mandela UniversityInventors: Cloudius Ray Sagandira, Paul Watts
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Patent number: 11001575Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: GrantFiled: August 15, 2019Date of Patent: May 11, 2021Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio Berdini, Ildiko Maria Buck, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, Christopher William Murray, David Norton, Marc O'Reilly, Alison Jo-Anne Woolford, Michael Liam Cooke, David Cousin, Stuart Thomas Onions, Jonathan Martin Shannon, John Paul Watts
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Publication number: 20210101887Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.Type: ApplicationFiled: March 28, 2018Publication date: April 8, 2021Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Steven HOWARD, Benjamin David CONS, Jeffrey David ST. DENIS, Charlotte Mary GRIFFITHS-JONES, Steven Douglas HISCOCK, Rhian Sara HOLVEY, Alan Richard BURNS, David COUSIN, Hannah Louise DEXTER, Guillaume François PARRA, John Paul WATTS, Robert JEWELL, Jennifer Ann STOCKWELL, Kim Louise HIRST, Isabelle Anne LEMASSON, David John NASH, James Daniel OSBORNE, Jonas Calleja PRIEDE, Nicholas Paul RICHARDS, Aaron Michael DUMAS, Brian Christopher BISHOP, David PARRY-JONES, Jeremy Peter SCOTT, Meenakshi Sundaram SHANMUGHAM, Peter Richard MULLENS, David Charles LATHBURY, Darren James DIXON, Matthew James GAUNT
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Publication number: 20210087147Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: July 31, 2018Publication date: March 25, 2021Inventors: Mark G. BOCK, David HARRISON, Alan Paul WATT, Roderick Alan PORTER, Nicolas Felix Pierre BOUTARD, Charles-Henry Robert Yves FABRITIUS, Grzegorz Witold TOPOLNICKI, Oleksandr LEVENETS
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Publication number: 20210087238Abstract: Described herein are improved cell penetrating peptides and related compositions and methods for their enhanced functional delivery.Type: ApplicationFiled: July 27, 2018Publication date: March 25, 2021Inventors: Katrin Hoffmann, Paula Cunningham, Shane Stone, Suzy Juraja, Tatjana Heinrich, Nadia Milech, Mark Anastasas, Maria Kerfoot, Paul Watt
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Publication number: 20210070708Abstract: The invention is directed to compounds of general formula (I) and pharmaceutical compositions containing such compounds. The compounds and compositions have valuable pharmaceutical properties. In particular, they may be used for the treatment of cancer. Novel intermediates and novel methods of preparation are also disclosed.Type: ApplicationFiled: July 14, 2020Publication date: March 11, 2021Applicant: BerGenBio ASAInventors: Jason John Shiers, John Paul Watts, Stuart Thomas Onions, Mohammed Abdul Quddus, Joseph William Wrigglesworth, Colin Peter Sambrook-Smith, Alan Naylor, Derek Londesbrough
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Publication number: 20210002261Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: December 18, 2018Publication date: January 7, 2021Inventors: David HARRISON, Alan Paul WATT, Mark G. BOCK
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Patent number: 10815223Abstract: This invention provides for flow and batch synthesis processes for the production of Lamivudine and Emtricitabine, including flow and batch synthesis processes wherein at least of the synthesis steps are conducted in a solvent free environment.Type: GrantFiled: June 13, 2017Date of Patent: October 27, 2020Assignee: Nelson Mandela Metropolitan UniversityInventors: Devender Mandala, Paul Watts