Abstract: A dispensing device, such as a calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate.

Abstract: A dispenser for dispensing sheet material from a roll. The roll has a location arrangement for releasably mounting the roll between a spigot and an oppositely facing support element for rotation about a longitudinal axis of the dispenser. The arrangement includes: a core around which the sheet material is wrapped, one end of the core being mounted or mountable relative to the support element, the other end having a wall region defining a generally hollow cylindrical portion projecting from the wrapped material, a generally axial slot being provided in the wall region extending to the free edge thereof; and a fixing provided on the cylindrical portion. The fixing has a bearing surface for rotatably engaging the spigot for rotational movement about the longitudinal axis, and a radial path to the bearing surface, the path being radially aligned with the slot in the core, whereby the end of the core may be laterally engaged with the spigot support element.

Abstract: A dispensing device, such as a calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate.

Abstract: A calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate.

Abstract: A mouth prop for insertion in use between the opposed tooth or gum regions of the patient's mandible or maxilla to space the patient's incisors thereapart, the mouth prop having a grippable portion which a clinician can use for assisting in the location and removal of the mouth prop and can be supplied with elements for delivering and/or sampling gases to or in the mouth and/or nasal region of a patient.

Abstract: A calendar is formed of a plurality of substrates. A first substrate carries indicia thereon which identifies selected time periods, such as days or months of the year. A second substrate is positioned adjacent to the first substrate. The second substrate defines a plurality of cavities dimensioned to individually retain a respective information carrying article, such as a web. Each of the cavities is corresponding supplied with a respective information carrying article. Each indicia on the first substrate is positionally associated with a respective cavity in the second substrate. A third substrate, positioned adjacent to the second substrate, is positioned to retain the information carrying articles releasably within the second substrate.

Abstract: Lipid-modified immune response modifier compounds, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract: A urine collection device for attachment to a pump and for a user in a supine, or reclined position, includes: an open-mouthed container having a rim around the mouth for being urged in use to seat generally around the periphery of the urine discharge region to receive urine discharged from the urethra, the container being adapted to fit between the legs of a user in a supine or reclined position, the container having at its lower part a reservoir basin in which fluid may collect in use when the container is applied to a user in a supine or reclined position, and an outlet in the lower part of the reservoir basin through which urine may be drawn from the container.

Abstract: The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

Abstract: The present invention provides methods, pharmaceutical compositions, and pharmaceutical combinations useful for treating lung cancer. Generally, the compositions include a 5-LO inhibitor in an amount effective to inhibit 5-lipoxygenase in an inhalable formulation. In some cases, the formulation may further include an IRM compound. Generally, the pharmaceutical combinations include a 5-LO inhibitor and an IRM compound in an inhalable formulation. Generally, the methods include administering to the subject an inhalable formulation that comprises a 5-lipoxygenase inhibitor having a cLogP of at least about 4.0 in an amount effective for treating lung cancer.

Abstract: The invention provides a method of activating neutrophils. Generally, the method includes contacting neutrophils with a neutrophil-activating IRM compound and/or a TLR8-selective agonist in an amount effective to activate the neutrophils. In some embodiments, the method may be used to treat a condition treatable by activating neutrophils. In another aspect, the invention provides pharmaceutical compositions that generally include a neutrophil-activating IRM compound and/or a TLR8-selective agonist, or a pharmaceutically acceptable form thereof, in an amount effective to activate neutrophils.