Abstract: Provided herein are bioengineered immunomodulatory fusion proteins and uses thereof for modulating immune responses, as well as uses for improving a response of a subject to a vaccine, or uses for treating a disease or disorder, such as cancer or a pathogen infection. Provided herein is a single chain trimeric CD40L Fc fusion protein comprising (a) three CD40 ligand CD40L subunits covalently linked to one another by peptide linkers (CD40L trimer); and (b) an Fc monomer peptide.

Abstract: Coating compositions comprise: a curable compound comprising: a core chosen from a C6 carbocyclic aromatic ring, a C2-5 heterocyclic aromatic ring, a C9-30 fused carbocyclic aromatic ring system, a C4-30 fused heterocyclic aromatic ring system, C1-20 aliphatic, and C3-20 cycloaliphatic, and three or more substituents of formula (1) wherein at least two substituents of formula (1) are attached to the aromatic core; provided that no substituents of formula (1) are in an ortho position to each other on the same aromatic ring of the core; a polymer; and one or more solvents, wherein the total solvent content is from 50 to 99 wt % based on the coating composition.

Abstract: A duplex bearing is configured for use with a nuclear reactor control rod drive mechanism. The duplex includes an outer member and an inner member wherein each defines an interior surface and an exterior surface. The outer member interior surface defines a first and second outer raceway; and the inner member defines a first and second inner raceway. A first plurality of load-carrying rolling elements and a first plurality of spacer rolling elements are disposed in a first annular cavity defined between the first inner raceway and first outer raceway. A second plurality of load-carrying rolling elements and a second plurality of spacer rolling elements are disposed in a second annular cavity defined between the second inner raceway and the second outer raceway. The duplex bearing is configured to operate with sealed de-ionized water exhibiting a temperature in the range of up to about 1200° F. as a sole lubricant.