Abstract: A method for determining an angular position of a rotating component is disclosed. A sensor system is positioned at a radial distance from an axis of rotation of the rotating component. A magnetic ring is arranged fixedly and concentrically on the rotating component, generating a magnetic field that changes with respect to the sensor system. The sensor system detects the magnetic field in which a signal is captured and evaluated with respect to the angular position. Errors in the measurement of the angular position can be corrected. The signal captured by the sensor system is evaluated with respect to the amplitude information of the magnetic field. A correction parameter is determined from the amplitude information, and an angle error is of the angular position is determined based on the correction parameter. The angle error is used to correct the angular position.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed that implement an automatically evolving code recommendation engine. In one example, the apparatus collects a user code snippet. The apparatus then determines a structured representation of the user code snippet. Next, the apparatus generates a recommended code snippet using the structured representation of the user code snippet. Then the apparatus obtains user-determined code snippet feedback comparing the user code snippet to the recommended code snippet, the user-determined code snippet feedback indicating one of a match, no match, or uncertain. Finally, the apparatus stores a code snippet training pair in a training database, the code snippet training pair including the user code snippet and the recommended code snippet.

Abstract: A silicon on insulator (SOI) photonic device having a waveguide is provided that includes a mode overlap portion with a topology optimized structure situated below an electrode of the capacitance structure. The device can significantly change a refractive index in a volume of mode overlap depending upon the applied potential to the capacitor and allows for a ? phase shift in a modest mode overlap volume. The topology optimized structure has a waveguide and substrate that are partitioned in three dimensions using an extruded projection design. The electrode is a transition metal di-chalcogenide monolayer sheet (2D TMD). The enhanced mode overlay from the topology optimized waveguide portion allows a large reduction in the length of the waveguide with the mode overlap to achieve the needed phase shift for a photonic device.

Abstract: Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.

Abstract: A method for patterning a layer increases the density of features formed over an initial patterning layer using a series of self-aligned spacers. A layer to be etched is provided, then an initial sacrificial patterning layer, for example formed using optical lithography, is formed over the layer to be etched. Depending on the embodiment, the patterning layer may be trimmed, then a series of spacer layers formed and etched. The number of spacer layers and their target dimensions depends on the desired increase in feature density. An in-process semiconductor device and electronic system is also described.

Abstract: A metrology apparatus for determining one or more parameters of a structure fabricated in or on a semiconductor substrate. The apparatus comprises a transducer array comprising a plurality of transducers positioned in a plane. The plurality of transducers comprises at least one transmitter transducer for emitting acoustic radiation in a frequency range from 1 GHz to 100 GHz towards the structure, and at least one receiver transducer for receiving acoustic radiation reflected and/or diffracted from the structure.

Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

Abstract: The present invention relates to methods and applications of using Drosophila cells to produce virus-like particles. Virus-like particles of enveloped viruses produced by the methods of the present invention have proteins correctly expressed, cleaved, and assembled. Ultimately, virus-like particles having good immunogenicity are obtained. The present invention also provides recombinant cells expressing virus-like particles and compositions containing virus-like particles.

Abstract: Highly effective pseudotyping of lentiviral vector with influenza HA, NA and M2 packaging gene constructs at the proper ratios. Lentivirus vector pseudotyped with influenza HA, especially pseudotyped with H5 and neuraminidase. Methods of inducing immune responses to influenza antigens or for transducing genes into cells to which influenza antigens bind using such lentivirus vectors. Methods for screening drugs which inhibit influenza infection using lentivirus pseudotyped with HA.

Abstract: The invention provides a system and method for a client connected to a server in a computer network to access a resource, such as an application, database (either local, server, or web-based), service and/or a file, stored in the network. The system comprises: the client in the network; the server in the network; an instance of the resource stored in at least one of the server and the client; a file associated with the application stored in at least one of the server and the client; and an access module operating to provide the client with access to the server. In the system at the client, a first icon associated with a said resource is provided and if the instance of the resource is stored at the server, the application is automatically accessed when the icon at the client is activated.