Patents by Inventor Paula J. Shadle

Paula J. Shadle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody purification
    Patent number: 5429746
    Abstract: This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: July 4, 1995
    Assignee: Smith Kline Beecham Corporation
    Inventors: Paula J. Shadle, John C. Erickson, Robert G. Scott, Thomas M. Smith
  • Process for purification of basic fibroblast growth factor
    Patent number: 5331095
    Abstract: The invention relates to a method of purifying basic fibroblast growth factor. The method involves the use of strong cation exchange chromatography followed by hydrophobic interaction chromatography and then by weak cation exchange chromatography.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: July 19, 1994
    Assignee: Scios Nova Inc.
    Inventors: Paula J. Shadle, Kate B. Silverness, Robert S. King
  • Conjugation of polymer to colony stimulating factor-1
    Patent number: 5153265
    Abstract: A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.
    Type: Grant
    Filed: August 30, 1990
    Date of Patent: October 6, 1992
    Assignee: Cetus Corporation
    Inventors: Paula J. Shadle, Kirston E. Koths, Margaret Moreland, Nandini Katre, Walter J. Laird, Lois Aldwin, Danute E. Nitecki, John D. Young
  • Conjugation of polymer to colony stimulating factor-1
    Patent number: 4847325
    Abstract: A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.
    Type: Grant
    Filed: January 20, 1988
    Date of Patent: July 11, 1989
    Assignee: Cetus Corporation
    Inventors: Paula J. Shadle, Kirston E. Koths, Margaret Moreland, Nandini Katre