Patents by Inventor Paulus F. C. van der Meij

Paulus F. C. van der Meij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of imidazolyl compounds
    Patent number: 7015333
    Abstract: A method for preparing an imidazolyl compound corresponding to the formula (I) by reacting a compound corresponding to formula (II) with a compound corresponding to formula (III) and then reacting the product with a compound corresponding to formula (IV)
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: March 21, 2006
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Jan-Maarten Verbeek, Paulus F. C. Van Der Meij
  • Solid salts of benzazepine compounds and pharmaceutical compositions containing them
    Patent number: 6998398
    Abstract: Pharmaceutically acceptable metal salts of compounds of formula (I): in which R1 is selected from the group consisting of (C1–C6)alkoxy(C1–C6)alkyl which may be substituted with (C1–C6)alkoxy, phenyl-(C1–C6)-alkyl and/or phenyloxy-(C1–C6)-alkyl group in which any phenyl group may be substituted with (C1–C6)alkyl, (C1–C6)alkoxy or halogen, and naphtyl-(C1–C6)-alkyl; R2 and R3 are each independently hydrogen or halogen; R4 is a biolabile ester forming group; and in which the salt is selected from the lithium salt and salts of bivalent metal ions such as magnesium, calcium and zinc.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 14, 2006
    Assignee: Solvay Pharmaceuticals BV
    Inventors: Joris A. van der Eerden, Paulus P. G. de Jong, Paulus F. C. van der Meij
  • Process for preparation of imidazolyl compounds
    Publication number: 20040158077
    Abstract: A method for preparing an imidazolyl compound corresponding to the formula (I) 1
    Type: Application
    Filed: November 14, 2003
    Publication date: August 12, 2004
    Applicant: Solvay Pharmaceuticals B.V.
    Inventors: Jan-Maarten Verbeek, Paulus F.C. Van Der Meij
  • Process for the preparation of enantiomerically pure imidazolyl compounds
    Patent number: 6365743
    Abstract: The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula wherein: n is 0 or 1; m is 1 or 2; R1 is hydrogen, methyl or ethyl; and C* denotes a chiral center; as well as its pharmaceutically acceptable acid addition salt. The invention further relates to a method of racemization and to a new acid addition salt of this formula I compound and D-pyroglutamic acid and to the hydrochloride monohydrate of the compound of formula I.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: April 2, 2002
    Assignee: Duphar International Research B.V.
    Inventors: Paulus F.C. van der Meij, Jan-Maarten Verbeek
  • Process for the preparation of enantiomerically pure imidazolyl compounds
    Patent number: 5663343
    Abstract: The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula ##STR1## wherein n is 0 or 1; m is 1 or 2;R.sub.
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: September 2, 1997
    Assignee: Duphar International Research B.V.
    Inventors: Paulus F. C. van der Meij, Jan-Maarten Verbeek
  • Production of dobutamine compounds
    Patent number: 5442120
    Abstract: The invention relates to a process for the production of an acid addition salt of a dobutamine compound of the general formula ##STR1## wherein R is a hydrogen atom or a methyl group, and n is 1 or 2,by reacting a mineral acid--addition salt of a dopamine compound of the general formula ##STR2## with a ketone of the general formula ##STR3## under the influence of a catalytic amount of a base, and in the presence of hydrogen and a hydrogenation catalyst, after which the pH of the reaction mixture is adjusted to approx. 6 at most and the product is isolated.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: August 15, 1995
    Assignee: Duphar International Research B.V.
    Inventors: Paulus F. C. van der Meij, Paulus P. G. de Jong