Abstract: Methods and systems for determining whether brain tissue is indicative of a disorder, such as a neurodegenerative disorder, are provided. The methods and systems generally utilize data processing techniques to assess a level of congruence between measured parameters obtained from magnetic resonance imaging (MRI) data and simulated parameters obtained from computational modeling of brain tissues.

Abstract: A computing system can communicate, over one or more networks, with computing devices of requesting users and transport providers of a transport service, and determine, based at least in part on location data from the computing devices of a cluster of the requesting users, that the cluster of requesting users is currently in transit on a third-party transit means. The computing system can then determine that a subset of the cluster will arrive at a common arrival location of the third-party transit means, and execute a timing optimization for the subset to determine, for each requesting user of the subset, an optimal time to transmit a transport request for an on-demand transport service at the common arrival location.