Patents by Inventor Pavel Kubalec

Pavel Kubalec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant immunoglobulin heavy chains comprising a sortase conjugation loop and conjugates thereof
    Patent number: 11136376
    Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: October 5, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Alfred Engel, Pavel Kubalec, Alfons Nichtl, Tobias Oelschlaegel, Rainer Schlecht
  • MULTIVALENT MONO- OR BISPECIFIC RECOMBINANT ANTIBODIES FOR ANALYTIC PURPOSE
    Publication number: 20210017272
    Abstract: The present disclosure relates to novel analyte-specific multivalent recombinant antibodies that are particularly useful in immunoassays. Specifically, hexavalent, octavalent and decavalent antibodies are disclosed, including their construction, production, characterization and use in target antigen detection assays.
    Type: Application
    Filed: March 20, 2020
    Publication date: January 21, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Tobias Oelschlaegel, Pavel Kubalec
  • RECOMBINANT IMMUNOGLOBULIN HEAVY CHAINS COMPRISING A SORTASE CONJUGATION LOOP AND CONJUGATES THEREOF
    Publication number: 20210009660
    Abstract: The disclosure describes a recombinant immunoglobulin heavy chain comprising a sortase conjugation loop, methods for conjugating and/or labeling such recombinant immunoglobulin heavy chains by use of the enzyme sortase and to the conjugates/labeled products obtained via the method.
    Type: Application
    Filed: March 23, 2018
    Publication date: January 14, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Alfred Engel, Pavel Kubalec, Alfons Nichtl, Tobias Oelschlaegel, Rainer Schlecht
  • Assay for measurement of antibodies binding to a therapeutic monoclonal antibody
    Patent number: 9081016
    Abstract: Methods and system for determination of an anti-<therapeutic monoclonal antibody> antibody (anti-<TmAB>AB) in vitro in a sample from a patient treated with a therapeutic monoclonal antibody (TmAB). Also, methods and systems for the determination of antigen specific antibodies of a particular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: July 14, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Veit Peter Grunert, Ursula Klause, Pavel Kubalec, Matthias Rothfuss, Barbara Upmeier
  • Method and system for processing multi-dimensional measurement data
    Patent number: 7676329
    Abstract: The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (?m/zi) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (Ii).
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: March 9, 2010
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ursula Garczarek, Pavel Kubalec, Wolfgang Hösel
  • Method and system for processing multi-dimensional measurement data
    Publication number: 20060080040
    Abstract: The invention provides a method for grouping measurement data obtained by effecting two or more techniques to provide characterization data characterizing at least one sample with respect to characterizing substances. According to one aspect of the invention, the grouping is effected on the basis of at least one statistical distribution of deviations (?m/zi) of a respective characterizing measurement value. According to another aspect of the invention, the grouping is effected on the basis of at least one collective characteristic of a plurality of respective quantitative measurement values (Ii).
    Type: Application
    Filed: April 22, 2005
    Publication date: April 13, 2006
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Ursula Garczarek, Pavel Kubalec, Wolfgang Hosel