Patents by Inventor Pawel Sikorski

Pawel Sikorski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230295215
    Abstract: The invention relates to new 5?mRNA end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method translates the RNA molecule.
    Type: Application
    Filed: February 12, 2021
    Publication date: September 21, 2023
    Inventors: Marcin WARMINSKI, Pawel SIKORSKI, Joanna KOWALSKA, Jacek JEMIELITY
  • Publication number: 20230130423
    Abstract: The invention relates to new mRNA 5? end cap analogs, RNA molecules containing them, their uses and methods for their in vitro synthesis, as well as a method for protein or peptide synthesis in vitro or in cell cultures, which method encompasses translation of the RNA molecule.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Macin WARMINSKI, Pawel SIKORSKI, Joanna KOWALSKA, Jacek JEMIELITY
  • Publication number: 20190300563
    Abstract: The present invention relates to nucleotides, analogs of mRNA 5?-end (cap) containing sulfur atom at the position 5? of 7-methylguanosine nucleoside. The disclosed compounds are recognized (bound and non-hydrolyzed) by DcpS enzyme (Decapping Scavenger), and thus may find therapeutic use as inhibitors thereof. DcpS is cap-specific enzyme with pyrophosphatase activity, which was identified as a therapeutic target in the treatment of spinal muscular atrophy (SMA). Some of the compounds disclosed have additional modifications in the phosphate chain, which modulate their affinity for DcpS enzyme.
    Type: Application
    Filed: January 27, 2017
    Publication date: October 3, 2019
    Inventors: Jacek Jemielity, Kaja Fac-Dabrowska, Blazej Wojtczak, Marek Baranowski, Anna Nowicka, Joanna Kowalska, Pawel Sikorski, Marcin Warminski
  • Publication number: 20190210924
    Abstract: The present invention is directed to methods of preparing biocement. The methods disclosed herein employ microbial or enzymatic means first to generate acid which dissolves CaCO3, and then to degrade urea, producing CO3? ions which increase the pH and lead to the reprecipitation of CaCO3. The precipitation of CaCO3 acts as a cementation process which can bind together particulate materials to yield mortars, concretes and suchlike. The invention further provides construction materials formed by the methods of the invention, and bacterial strains which can be used in the methods of the invention to generate organic acids.
    Type: Application
    Filed: June 23, 2017
    Publication date: July 11, 2019
    Applicant: Universitetet i Oslo
    Inventors: Anja Røyne, Alexander Wentzel, Pawel Sikorski