Patents by Inventor Pedro Harold Han Hermkens
Pedro Harold Han Hermkens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11834391Abstract: The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low IC50 values against the asexual blood stages and gametocytes of malaria parasites. Furthermore, the pantothenamide analogues of this invention are characterized by low hepatic metabolism. Therefore, pantothenamide analogues of the invention are particularly suitable for use in therapeutic and/or prophylactic treatment of protozoan infections in a human or animal subject in need thereof. The invention further provides pharmaceutical formulations comprising the pantothenamide analogues as well as the therapeutic and/or prophylactic uses of the pantothenamide analogues and pharmaceutical formulations comprising them.Type: GrantFiled: January 20, 2023Date of Patent: December 5, 2023Assignee: MMV MEDICINES FOR MALARIA VENTUREInventors: Josephus Schalkwijk, Pedro Harold Han Hermkens, Koen Jakob Dechering, Roger Victor Bonnert
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Publication number: 20230159437Abstract: The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low IC50 values against the asexual blood stages and gametocytes of malaria parasites. Furthermore, the pantothenamide analogues of this invention are characterized by low hepatic metabolism. Therefore, pantothenamide analogues of the invention are particularly suitable for use in therapeutic and/or prophylactic treatment of protozoan infections in a human or animal subject in need thereof. The invention further provides pharmaceutical formulations comprising the pantothenamide analogues as well as the therapeutic and/or prophylactic uses of the pantothenamide analogues and pharmaceutical formulations comprising them.Type: ApplicationFiled: January 20, 2023Publication date: May 25, 2023Inventors: JOSEPHUS SCHALKWIJK, PEDRO HAROLD HAN HERMKENS, KOEN JAKOB DECHERING, ROGER VICTOR BONNERT
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Patent number: 11572336Abstract: The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low IC50 values against the asexual blood stages and gametocytes of malaria parasites. Furthermore, the pantothenamide analogues of this invention are characterized by low hepatic metabolism. Therefore, pantothenamide analogues of the invention are particularly suitable for use in therapeutic and/or prophylactic treatment of protozoan infections in a human or animal subject in need thereof. The invention further provides pharmaceutical formulations comprising the pantothenamide analogues as well as the therapeutic and/or prophylactic uses of the pantothenamide analogues and pharmaceutical formulations comprising them.Type: GrantFiled: December 30, 2019Date of Patent: February 7, 2023Assignee: MMV MEDICINES FOR MALARIA VENTUREInventors: Josephus Schalkwijk, Pedro Harold Han Hermkens, Koen Jakob Dechering, Roger Victor Bonnert
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Publication number: 20220073450Abstract: The present invention provides compounds that have antimalarial activity. More in particular, the present invention provides novel compounds that are analogues of pantothenamides. The pantothenamide analogues of this invention have particularly low IC50 values against the asexual blood stages and gametocytes of malaria parasites. Furthermore, the pantothenamide analogues of this invention are characterized by low hepatic metabolism. Therefore, pantothenamide analogues of the invention are particularly suitable for use in therapeutic and/or prophylactic treatment of protozoan infections in a human or animal subject in need thereof. The invention further provides pharmaceutical formulations comprising the pantothenamide analogues as well as the therapeutic and/or prophylactic uses of the pantothenamide analogues and pharmaceutical formulations comprising them.Type: ApplicationFiled: December 30, 2019Publication date: March 10, 2022Inventors: JOSEPHUS SCHALKWIJK, PEDRO HAROLD HAN HERMKENS, KOEN JAKOB DECHERING, ROGER VICTOR BONNERT
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Publication number: 20180282279Abstract: The present invention concerns novel pantothenamide analogues having antimicrobial activity. In particular, the pantothenamide analogues of the present invention are not sensitive to pantetheinase activity. For the first time, pantothenamide analogues are provided that are suitable for use in therapeutic and or prophylactic treatment of microbial infection in a human or animal subject in need thereof.Type: ApplicationFiled: November 6, 2015Publication date: October 4, 2018Inventors: Pedro Harold Han Hermkens, Josephus Schalkwijk, Patrick Antonius Martinus Jansen, Peter Botman
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Patent number: 9388156Abstract: The invention relates to novel compounds that are useful for modulating mitochondrial morphology and/or expression of OXPHOS enzymes and/or cellular ROS. The compounds are derivatives of TroloxrM wherein the carboxylic acid moiety is replaced by an amide moiety and wherein the nitrogen atom of the amide moiety is connected via a linker to a cationic nitrogen atom. The compounds of the invention are formulated into pharmaceutical or cosmetic compositions. The invention further relates to methods wherein the compounds of the invention are used for treating or preventing mitochondrial disorders, conditions associated with mitochondrial dysfunction, including adverse drug effects, and/or neoplastic diseases. The invention also relates to cosmetic methods for treating or delaying further aging of the skin and veterinary applications.Type: GrantFiled: July 12, 2013Date of Patent: July 12, 2016Assignee: Khondiron IP B.V.Inventors: Richard Hendrik Blaauw, Ruben Gerardus George Leenders, Geert Jan Sterk, Pedro Harold Han Hermkens
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Publication number: 20150166501Abstract: The invention relates to novel compounds that are useful for modulating mitochondrial morphology and/or expression of OXPHOS enzymes and/or cellular ROS. The compounds are derivatives of TroloxrM wherein the carboxylic acid moiety is replaced by an amide moiety and wherein the nitrogen atom of the amide moiety is connected via a linker to a cationic nitrogen atom. The compounds of the invention are formulated into pharmaceutical or cosmetic compositions. The invention further relates to methods wherein the compounds of the invention are used for treating or preventing mitochondrial disorders, conditions associated with mitochondrial dysfunction, including adverse drug effects, and/or neoplastic diseases. The invention also relates to cosmetic methods for treating or delaying further aging of the skin and veterinary applications.Type: ApplicationFiled: July 12, 2013Publication date: June 18, 2015Applicant: Khondrion IP B.V.Inventors: Richard Hendrik Blaauw, Ruben Gerardus George Leenders, Geert Jan Sterk, Pedro Harold Han Hermkens
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Patent number: 8133885Abstract: The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of these derivatives to modulate glucocorticoid receptor activity.Type: GrantFiled: February 14, 2006Date of Patent: March 13, 2012Assignee: Merck Sharp & Dohme Corp.Inventors: Ralf Plate, Guido Jenny Rudolf Zaman, Pedro Harold Han Hermkens, Christiaan Gerardus Johannes Maria Jans, Rogier Christian Buijsman, Adrianus Petrus Antonius De Man, Paolo Giovanni Martino Conti, Scott James Lusher, Willem Hendrik Abraham Dokter
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Patent number: 8124647Abstract: This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof.Type: GrantFiled: September 3, 2010Date of Patent: February 28, 2012Assignee: N.V. OrganonInventors: Pedro Harold Han Hermkens, Herman Thijs Stock, Jaap Van Der Louw, Neeltje Miranda Teerhuis, Johannes Petrus Maria Lommerse
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Publication number: 20110065768Abstract: This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof.Type: ApplicationFiled: September 3, 2010Publication date: March 17, 2011Inventors: PEDRO HAROLD HAN HERMKENS, HERMAN THIJS STOCK, JAAP VAN DER LOUW, NEELTJE MIRANDA TEERHUIS, JOHANNES PETRUS MARIA LOMMERSE
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Publication number: 20110009428Abstract: The compounds of the subject invention have a structure according to formula I: wherein X is S or SO2; R1 is (1C-6C)alkyl, (3C-6C)alkenyl, or (3C-6C)alkynyl, each optionally substituted with (3C-6C)cycloalkyl, OH, OC(O)(1C-4C)alkyl, (1C-4C)alkoxy, halogen, cyano, formyl, C(O)(1C-4C)alkyl, CO2H, CO2(1C-4C)alkyl, C(O)NR5R6, S(O)(1C-4C)alkyl or S(O)2(1C-4C)alkyl; R2 is hydrogen, (1C-4C)alkyl or C(O)(1C-4C)alkyl; R3 is a phenyl group optionally substituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, (1C-4C)fluoroalkoxy, halogen, cyano or nitro; or R3 is a 5- or 6-membered aromatic heterocyclic ring structure optionally substituted with (1C-4C)alkyl, (1C-4C)fluoroalkyl, (1C-4C)alkoxy, halogen or cyano; R4 is a phenyl group or an aromatic 6-membered heterocycle, substituted at the ortho position with 1-hydroxy(1C-4C)alkyl, (1C-4C)alkoxy, C(O)(1C-4C)alkyl, CO2(1C-4C)alkyl, C(O)NH2, cyano, nitro, or CH?NOR7, and optionally further substituted with (1C-2C)alkyl, (1C-2C)fluoroalkyl or halogen; or R4Type: ApplicationFiled: September 22, 2010Publication date: January 13, 2011Applicant: N.V. OrganonInventors: Jaap Van Der Louw, Neeltje Miranda Teerhuis, Johannes Petrus Maria Lommerse, Herman Thijs Stock, Pedro Harold Han Hermkens
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Patent number: 7812036Abstract: The compounds of the subject invention have a structure according to formula I: wherein each of the substituents is given the definition as set forth in the specification and claims, or a salt or hydrate form thereof.Type: GrantFiled: April 21, 2005Date of Patent: October 12, 2010Assignee: N.V. OrganonInventors: Jaap Van Der Louw, Neeltje Miranda Teerhuis, Johannes Petrus Maria Lommerse, Herman Thijs Stock, Pedro Harold Han Hermkens
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Patent number: 7795280Abstract: This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof.Type: GrantFiled: November 3, 2003Date of Patent: September 14, 2010Assignee: N.V. OrganonInventors: Pedro Harold Han Hermkens, Herman Thijs Stock, Jaap Van Der Louw, Neeltje Miranda Teerhuis, Johannes Petrus Maria Lommerse
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Patent number: 7737136Abstract: The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.Type: GrantFiled: April 1, 2003Date of Patent: June 15, 2010Assignee: N.V. OrganonInventors: Pedro Harold Han Hermkens, Hans Lucas, Paul Peter Marie Antonius Dols, Johannes Bernardus Maria Rewinkel, Brigitte Johanna Bernita Folmer
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Publication number: 20090062262Abstract: The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 14, 2006Publication date: March 5, 2009Applicant: N.V. ORGANONInventors: Ralf Plate, Guido Jenny Rudolf Zaman, Pedro Harold Han Hermkens, Christiaan Gerardus Johannes Maria Jans, Rogier Christian Buijsman, Adrianus Petrus Antonius De Man, Paolo Giovanni Martino Conti, Scott James Lusher, Willem Hendrik Abraham Dokter
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Publication number: 20050171087Abstract: The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.Type: ApplicationFiled: April 1, 2003Publication date: August 4, 2005Inventors: Pedro, Harold, Han Hermkens, Hans Lucas, Paul, Peter, Marie, Antonius Dols, Johannes, Bernardus, Maria Rewinkel, Brigitte, Johanna, Bernita Folmer