Patents by Inventor Peiying Liu
Peiying Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240159204Abstract: The present invention relates to a reinforced bulging tank of a launch vehicle and a manufacturing method therefor. The tank is made of metal material with good plasticity. Firstly, the tank is manufactured by welding annealed plastic metal materials, wherein internal longitudinal reinforcing ribs and internal annular frames/annular plates of barrel sections are welded with a barrel section shell by a low energy laser welding method, and tank bottoms are progressively welded by a plurality of conical sections. Weldments are strengthened and formed through internal pressure bulging under the constraint of external tooling. The outer walls of the barrel sections are not radially deformed under the constraint of a plurality of small width metal rings, and the metal rings are not connected to each other axially. The strength of the materials can be greatly improved by a deep cooling bulging technology.Type: ApplicationFiled: May 9, 2023Publication date: May 16, 2024Inventors: Lipeng Wang, Peiying Zhu, Chenlong Liu, Zhongyi Liu
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Publication number: 20240089213Abstract: The present disclosure relates to priority flow control (PFC) storm detection and processing methods. In one example method, a first network node performs PFC detection on a first port queue of a first port, and determines that a first preset condition is met. The first preset condition includes: detection is performed in N consecutive first time segments, when the detection is performed in each first time segment, a quantity of first PFC frames sent by the first port queue to a second network node is greater than a first threshold, and a quantity of one or more data packets received by the first port queue from the second network node is less than a second threshold. The first PFC frame is used to indicate the second network node to suspend sending all data flows in the first port queue, and N is a positive integer.Type: ApplicationFiled: November 15, 2023Publication date: March 14, 2024Inventors: Peiying TAO, Yu WANG, Heyang LIU, Hewen ZHENG, Jinfeng YAN
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Publication number: 20240059334Abstract: Described herein is a vessel cart including a base, a stand and a clamp. The base is configured to abut a lower portion of a vessel and hold the vessel upright when the vessel is loaded to the vessel card. The stand is connected to or formed with the base. The clamp is connected to the stand and configured to selectively grip an upper portion of the vessel. The clamp is also configured to open and close in a plane substantially parallel to a first surface of the base facing the clamp to allow the vessel to move laterally or radially relative to the clamp when the vessel is being loaded to the vessel cart or unloaded from the vessel cart.Type: ApplicationFiled: August 21, 2023Publication date: February 22, 2024Inventors: Flora Peiying Liu, Marc Miller Graham
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Patent number: 11352360Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: GrantFiled: March 21, 2019Date of Patent: June 7, 2022Assignees: Rigel Pharmaceuticals, hic., Bristol-Myers Squibb CompanyInventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Padmakar Dame, Hasibur Rahaman, Jayakumar Sankara Warrier
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Patent number: 10961239Abstract: The invention relates generally to compounds of formula (I) that modulate the activity of TGF?R-1 and TGF?R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.Type: GrantFiled: January 3, 2018Date of Patent: March 30, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Robert M. Borzilleri, Upender Velaparthi, Chetan Padmakar Darne, Peiying Liu, Manjunatha Narayana Rao Kamble, Balaji Seshadri, Raju Mannoori, Hasibur Rahaman, Jayakumar Sankara Warrier
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Publication number: 20200031832Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: ApplicationFiled: March 21, 2019Publication date: January 30, 2020Inventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Padmakar Darne, Hasibur Rahaman, Jayakumar Sankara Warrier
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Publication number: 20190337942Abstract: The invention relates generally to compounds of formula (I) that modulate the activity of TGF?R-1 and TGF?R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and N disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.Type: ApplicationFiled: January 3, 2018Publication date: November 7, 2019Inventors: Robert M. Borzilleri, Upender Velaparthi, Chetan Padmakar Darne, Peiying Liu, Manjunatha Narayana Rao Kamble, Balaji Seshadri, Raju Mannoori, Hasibur Rahaman, Jayakumar Sankara Warrier
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Patent number: 10287295Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: GrantFiled: January 2, 2018Date of Patent: May 14, 2019Assignees: Rigel Pharmaceuticals, Inc., Bristol-Meyers Squibb CompanyInventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Padmakar Darne, Hasibur Rahaman, Jayakumar Sankara Warrier
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Publication number: 20180127426Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: ApplicationFiled: January 2, 2018Publication date: May 10, 2018Inventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Darne, Hasibur Rahaman, Jayakumar Sankara Warrier
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Patent number: 9884868Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: GrantFiled: February 26, 2016Date of Patent: February 6, 2018Assignees: Rigel Pharmaceuticals, Inc., Bristol-Myers Squibb CompanyInventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Darne, Hasibur Rahaman, Jayakumar Sankara Warrier
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Patent number: 9649466Abstract: Systems and methods for delivery of gas mixtures to humans inside an MRI scanner, including while monitoring and recording physiological parameters.Type: GrantFiled: February 17, 2015Date of Patent: May 16, 2017Assignee: The Board of Regents of the University of Texas SystemInventors: Hanzhang Lu, Peiying Liu
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Patent number: 9598423Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: GrantFiled: November 14, 2014Date of Patent: March 21, 2017Assignee: Bristol-Myers Squibb CompanyInventors: Upender Velaparthi, Chetan Padmakar Darne, Peiying Liu, Mark D. Wittman, Bradley C. Pearce, Erika M. V. Araujo, Bireshwar Dasgupta, Jalathi Surendran Nair, Sakthi Kumaran Janakiraman, Chandrasekhar Reddy Rachamreddy, Mallikarjuna Rao Mettu, Arul Mozhi Selvan Subbiah Karuppiah, Bandreddy Subba Reddy, Pulicharla Nagalakshmi, Rajesh Onkardas Bora, Shilpa Holehatti Maheshwarappa, Selvakumar Kumaravel, Dibakar Mullick, Ramesh Sistla
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Patent number: 9556179Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: GrantFiled: December 20, 2013Date of Patent: January 31, 2017Assignee: Bristol-Myers Squibb CompanyInventors: Upender Velaparthi, Chetan Padmakar Darne, Dharmpal S. Dodd, Anthony J. Sampognaro, Mark D. Wittman, Selvakumar Kumaravel, Dibakar Mullick, Peiying Liu, Chandrasekhar Reddy Rachamreddy
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Publication number: 20160311824Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: ApplicationFiled: November 14, 2014Publication date: October 27, 2016Inventors: Upender Velaparthi, Chetan Padmakar Dame, Peiying Liu, Mark D Wittman, Bradley C. Pearce, Erika M.V. Araujo, Bireshwar Dasgupta, Jalathi Surendran Nair, Sakthi Kumaran Janakiraman, Chandrasekhar Reddy Rachamreddy, Mallikarjuna Rao Mettu, Arul Mozhi Selvan Subbiah Karuppiah, Bandreddy Subba Reddy, Pulicharla Nagalakshmi, Rajesh Onkardas Bora, Shilpa Holehatti Maheshwarappa, Selvakumar Kumaravel, Dibakar Mullick, Ramesh Sistla
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Patent number: 9475817Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: GrantFiled: December 20, 2013Date of Patent: October 25, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Upender Velaparthi, Chetan Padmakar Darne, Dharmpal S. Dodd, Peiying Liu, Christopher P. Mussari, Mark D. Wittman, Selvakumar Kumaravel, Dibakar Mullick
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Publication number: 20160257690Abstract: Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, R1 and R? are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-?, and can be used to treat disease by blocking TGF-? signaling.Type: ApplicationFiled: February 26, 2016Publication date: September 8, 2016Inventors: Todd Kinsella, Marina Gelman, Hui Hong, Ihab S. Darwish, Rajinder Singh, Jiaxin Yu, Robert M. Borzilleri, Upender Velaparthi, Peiying Liu, Chetan Darne, Hasibur Rahaman, Jayakumar Sankara Warrier
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Publication number: 20160122358Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: ApplicationFiled: January 13, 2016Publication date: May 5, 2016Inventors: Upender Velaparthi, Chetan Padmakar Darne, Peiying Liu, Mark D. Wittman, Bradley C. Pearce, Erika M. V. Araujo, Bireshwar Dasgupta, Jalathi Surendran Nair, Sakthi Kumaran Janakiraman, Chandrasekhar Reddy Rachamreddy, Mallikarjuna Rao Mettu, Arul Mozhi Subbiah Karuppiah, Subba Reddy Bandreddy, Nagalakshmi Pulicharla, Rajesh Onkardas Bora, Shilpa Maheshwarappa Holehatti, Selvakumar Kumaravel, Dibakar Mullick, Ramesh Kumar Sistla
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Patent number: 9273058Abstract: The invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.Type: GrantFiled: November 14, 2014Date of Patent: March 1, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Upender Velaparthi, Chetan Padmakar Darne, Peiying Liu, Mark D. Wittman, Bradley C. Pearce, Erika M. V. Araujo, Bireshwar Dasgupta, Jalathi Surendran Nair, Sakthi Kumaran Janakiraman, Chandrasekhar Reddy Rachamreddy, Mettu Mallikarjuna Rao, Arul Mozhi Selvan Subbiah Karuppiah, Bandreddy Subba Reddy, Pulicharla Nagalakshmi, Rajesh Onkardas Bora, Shilpa Holehatti Maheshwarappa, Selvakumar Kumaravel, Dibakar Mullick, Ramesh Sistla
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Patent number: 9242967Abstract: Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR2 or N; Q is a heteroaryl; and R1 is defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 assoC1ated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.Type: GrantFiled: January 16, 2015Date of Patent: January 26, 2016Assignee: Bristol-Myers Squibb CompanyInventors: Upender Velaparthi, Peiying Liu
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Patent number: D1027859Type: GrantFiled: June 8, 2023Date of Patent: May 21, 2024Assignee: Eve Energy Storage Co., LtdInventors: Xuepei Xu, Yuncong Pang, Yulang Zou, Changjun Shuai, Zhao Tian, Shilei Liu, Xiaomei Tang, Peiying Long, Zihui Zhao, Haohao Yi, Yubao Meng, Xiang Chen