Patents by Inventor Peng Cho Tang

Peng Cho Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
    Patent number: 7582756
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: September 1, 2009
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Pyrrole substituted 2-indolinone protein kinase inhibitors
    Patent number: 7572924
    Abstract: The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: August 11, 2009
    Assignees: Sugen, Inc., Pharmacia & Upjohn Co.
    Inventors: Peng Cho Tang, Todd Anthony Miller, Xiaoyuan Li, Connie Li Sun, Chung Chen Wei, Shahrzad Shirazian, Congxin Liang, Tomas Vojkovsky, Asaad S. Nematalla, Michael Hawley
  • Dicyclooctane Derivatives, Preparation Processes and Medical Uses Thereof
    Publication number: 20090176847
    Abstract: The present invention relates to new dicyclooctane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and to uses for treatment especially for dipeptidyl peptidase inhibitor (DPPIV), in which each substituent group of general formula (I) is as defined in specification.
    Type: Application
    Filed: March 28, 2007
    Publication date: July 9, 2009
    Inventors: Peng Cho Tang, Zhigang Lin, Lei Zhang, Qian Wang, Jialiang Yang, Yang Wang, Fuqiang Zhao
  • Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
    Patent number: 7435861
    Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: October 14, 2008
    Assignee: Cardax Pharmaceuticals, Inc.
    Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
  • Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
    Publication number: 20080221377
    Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
    Type: Application
    Filed: June 18, 2007
    Publication date: September 11, 2008
    Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick, Cristi L. Braun
  • 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20080045709
    Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
    Patent number: 7256189
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 14, 2007
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu (Alan) Jin, Paul M. Herrinton, Michael A. Mauragis
  • Methods for the synthesis of astaxanthin
    Patent number: 7247752
    Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: July 24, 2007
    Assignee: Cardax Pharmaceuticals, Inc.
    Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
  • Method and compositions for inhibiting cell proliferative disorders
    Patent number: 7217737
    Abstract: The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity HER2 or EGFR.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: May 15, 2007
    Assignees: Yissum Research and Development Company of the Hebrew University of Jerusalem, Sugen, Inc.
    Inventors: Hui Chen, Aviv Gazit, Alexander Levitzki, Klaus Peter Hirth, Elaina Mann, Peng Cho Tang, Laura K. Shawver, Jianming Tsai
  • (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors
    Patent number: 7214700
    Abstract: The present invention relates to (2-oxindol-3-ylidenyl)acetic acid derivatives which modulate the activity of protein kinases and are therefore useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: May 8, 2007
    Assignee: Sugen Inc.
    Inventors: Chung Chen Wei, Peng Cho Tang
  • Indolinone combinatorial libraries and related products and methods for the treatment of disease
    Patent number: 7202265
    Abstract: The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction, including cell proliferative diseases such as cancer, atherosclerosis, arthritis and restenosis and metabolic diseases such as diabetes. The present invention features indolinone compounds that potently inhibit protein kinases and related products and methods. Inhibitors specific to the FLK protein kinase can be obtained by adding chemical substituents to the 3-[(indole-3-yl)methylene]-2-indolinone, in particular at the 1? position of the indole ring. Indolinone compounds that specifically inhibit the FLK and platelet derived growth factor protein kinases can harbor a tetrahydroindole or cyclopentano-b-pyrrol moiety.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: April 10, 2007
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Connie Li Sun, Gerald McMahon, Klaus Peter Hirth, Laura Kay Shawver
  • Bicyclic protein kinase inhibitors
    Patent number: 7189721
    Abstract: The present invention relates to novel 3-hetero-arylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: March 13, 2007
    Assignee: Sugen Inc.
    Inventors: Peng Cho Tang, Li Sun, Gerald McMahon
  • 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
    Patent number: 7179910
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: February 20, 2007
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu (Alan) Jin, Paul M. Herrinton, Michael A. Mauragis
  • 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors
    Publication number: 20070027149
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: August 28, 2006
    Publication date: February 1, 2007
    Inventors: Huiping Guan, Congxin Liang, Connie Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul Herrinton, Michael Mauragis
  • 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
    Patent number: 7157577
    Abstract: The present invention relates to 5-sulfonamido substituted indolinones that modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: January 2, 2007
    Assignee: Sugen Inc.
    Inventors: Peng Cho Tang, Congxin Liang, Todd Miller, Kenneth E. Lipson
  • Pyrrole substituted 2-indolinone protein kinase inhibitors
    Patent number: 7125905
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: October 24, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peng Cho Tang, Todd A. Miller, Xiaoyuan Li, Li Sun, Chung Chen Wei, Shahrzad Shirazian, Congxin Liang, Tomas Vojkovsky, Asaad S. Nematalla, Michael Hawley
  • Pyrrole substituted 2-indolinone protein kinase inhibitors
    Patent number: 7119090
    Abstract: The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: October 10, 2006
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Li Sun, Gerald McMahon
  • Geometrically restricted 3-cyclopentylidene-1,3-dihydroindol-2-ones as potent protein tyrosine kinase inhibitors
    Patent number: 7105562
    Abstract: The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula: wherein R1–R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases (“PKs”). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: August 5, 2004
    Date of Patent: September 12, 2006
    Assignee: Sugen, Inc.
    Inventors: Fang-Jie Zhang, Jingrong Cui, Chung Chen Wei, Peng Cho Tang
  • Indolinone derivatives as protein kinase/phosphatase inhibitors
    Patent number: 7071332
    Abstract: The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: July 4, 2006
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, G. Davis Harris, Xiaoyuan Li
  • Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives
    Patent number: 7053113
    Abstract: The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: May 30, 2006
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company LLC
    Inventors: Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Peng Cho Tang