Abstract: The present invention provides a shoe with interchangeable vamp and sole which comprises a sole (10) with a heel (11) which an air inlet guide (14) is formed in and with an air inlet hole (111) located at the bottom, exposed portion; a guide hole (141) located at the inside, near the rearmost of the portion of the sole (10); a receiving channel (12) with a channel inlet (121) and a channel cavity (122); a plurality of annular segments (13) which are put in the channel cavity (122); an upper-shoe assembly (20) which has a vamp (21), an insole (22); a welt (211) which extends downward from the connected portion of the vamp (21) and the sole (22), a gas bladder (24) with an air inlet (241) and a bladder glove (23); by inflating or deflating the gas bladder (24), the vamp and the sole could be interchanged with the same size of device.