Patents by Inventor Peng Luan

Peng Luan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20120100148
    Abstract: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
    Type: Application
    Filed: December 1, 2009
    Publication date: April 26, 2012
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Joseph Vincent Manetta, Ying Tang, Derrick Ryan Witcher
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Patent number: 8148508
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: April 3, 2012
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • Methods and constructs for high yield expression of clostripain
    Patent number: 8003362
    Abstract: The invention provides methods and nucleic acid constructs to express clostripain. The source of the coding region for recombinantly expressed clostripain is Clostridium histolyticum.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 23, 2011
    Assignee: Medtronic Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Barton Holmquist
  • ANTI-HEPCIDIN-25 SELECTIVE ANTIBODIES AND USES THEREOF
    Publication number: 20110189190
    Abstract: Monoclonal antibodies are provided that bind to the N-terminus of human hepcidin-25 and are characterized as having high affinity and selectivity for the polypeptide. The antibodies of the invention are useful for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment of various disorders, such as anemia, in a human subject. The antibodies of the invention are also useful as analytical tools, such as in sandwich ELISA.
    Type: Application
    Filed: July 29, 2009
    Publication date: August 4, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Ying Tang, Derrick Ryan Witcher, Pia Pauliina Yachi
  • ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF
    Publication number: 20110129480
    Abstract: Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
    Type: Application
    Filed: December 1, 2009
    Publication date: June 2, 2011
    Inventors: Donmienne Doen Mun Leung, Peng Luan, Joseph Vincent Manetta, Ying Tang, Derrick Ryan Witcher
  • METHOD FOR ENZYMATIC PRODUCTION OF GLP-2(1-33) AND GLP-2(1-34) PEPTIDES
    Publication number: 20110130556
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: August 23, 2010
    Publication date: June 2, 2011
    Applicant: NPS PHARMACEUTICALS, INC.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
    Publication number: 20110027261
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Application
    Filed: August 31, 2010
    Publication date: February 3, 2011
    Applicant: ELI LILLY AND COMPANY
    Inventors: Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, Peng Luan, Derrick Ryan Witcher
  • Anti-hepcidin antibodies and uses thereof
    Patent number: 7820163
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, Peng Luan, Derrick Ryan Witcher
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Patent number: 7781567
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 24, 2010
    Assignee: NPS Pharmaceuticals, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seog Seo
  • METHODS AND DNA CONSTRUCTS FOR HIGH YIELD PRODUCTION OF POLYPEPTIDES
    Publication number: 20090170192
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 2, 2009
    Applicant: RESTORAGEN, INC.
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
    Publication number: 20090136495
    Abstract: Monoclonal antibodies are provided that selectively bind human hepcidin-25 and are characterized as having high affinity for human hepcidin-25 and strong human mature hepcidin neutralizing properties. The antibodies of the invention are useful therapeutically for increasing serum iron levels, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a human and for the treatment and diagnosis of mature hepcidin-promoted disorders such as anemia, in a human subject.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 28, 2009
    Inventors: Dennis Patrick Gately, Donmienne Doen Mun Leung, Barbara Anne Swanson, Ying Tang, YuPing Anthony Cai, LuHong He, Peng Luan, Derrick Ryan Witcher
  • Methods and DNA constructs for high yield production of polypeptides
    Patent number: 7501484
    Abstract: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: March 10, 2009
    Assignee: Restoragen, Inc
    Inventors: James A. Williams, Peng Luan, Yuannan Xia, Scott Harley
  • Method for universal enzymatic production of bioactive peptides
    Patent number: 7498148
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: March 3, 2009
    Assignee: Restoragen, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • TARGETED DELIVERY AND EXPRESSION OF PROCOAGULANT HEMOSTATIC ACTIVITY
    Publication number: 20080241233
    Abstract: A platelet substitute consisting of large unilamellar lipid vesicles that contain phosphatidylserine or another procoagulant (clot-promoting) phospholipid, a protein that has binding affinity for collagen or other component of the vessel wall that becomes exposed upon vessel injury, and/or a phospholipid scramblase, has been developed. This platelet substitute provides a means for selectively delivering procoagulant phospholipids and/or fatty acids to the site of vessel injury through targeted adherence to collagen or other component exposed upon vessel injury. These are particularly effective due to the combination of targeting procoagulant vesicles to a site of injury, and triggered exposure of phosphatidylserine (PS) on the surface.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Inventors: Peter J. Sims, Pamela B. Conley, Peng Luan, David R. Phillips
  • METHOD FOR UNIVERSAL ENZYMATIC PRODUCTION OF BIOACTIVE PEPTIDES
    Publication number: 20080153129
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 21, 2007
    Publication date: June 26, 2008
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Method for universal enzymatic production of bioactive peptides
    Patent number: 7335486
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: February 26, 2008
    Assignee: Restoragen, Inc.
    Inventors: Fred W. Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin H. Merrifield, Mary J. Bossard, Barton Holmquist, Jin Seog Seo
  • Method for enzymatic production of GLP-2(1-33) and GLP-2(1-34) peptides
    Publication number: 20060024778
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: February 2, 2006
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Jin Seo
  • Method for universal enzymatic production of bioactive peptides
    Publication number: 20060008870
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: January 12, 2006
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Daniel Strydom, Edwin Merrifield, Mary Bossard, Barton Holmquist, Jin Seo
  • Method for enzymatic production of GLP-1 (7-36) amide peptides
    Publication number: 20050260701
    Abstract: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.
    Type: Application
    Filed: November 24, 2004
    Publication date: November 24, 2005
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Mary Bossard, Barton Holmquist, Edwin Merrifield, Daniel Strydom
  • Methods and constructs for high yield expression of clostripain
    Publication number: 20050244924
    Abstract: The invention provides methods and nucleic acid constructs to express clostripain.
    Type: Application
    Filed: November 24, 2004
    Publication date: November 3, 2005
    Inventors: Fred Wagner, Peng Luan, Yuannan Xia, Barton Holmquist