Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.

Abstract: An e-gaming entertainment system includes a central control platform, a plurality of light devices and a plurality of audio devices. The central control platform receives light adjustment instructions or sound adjustment instructions, converts the light adjustment instructions or the sound adjustment instructions into light adjustment execution commands or sound adjustment execution commands, and sends the light adjustment execution commands or the sound adjustment execution commands through a wired or wireless way forward to the light devices or audio devices correspondingly. The light devices receive the light adjustment execution commands and perform light adjustment operations. The audio devices receive the sound adjustment execution commands and perform sound adjustment operations. The e-gaming entertainment system is efficient and convenient. The central control platform controls multiple light devices and audio devices in a wireless or wired manner.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may determine that data is buffered for transmission via a first logical channel that does not have a valid scheduling request configuration. The UE may transmit, via a scheduling request resource of a second logical channel that has a valid scheduling request configuration, a scheduling request for resources to transmit the data buffered for transmission via the first logical channel. Numerous other aspects are described.

Abstract: Embodiments of the present disclosure relate to managing communications between slices on a storage device engine. Shared slice memory of a storage device engine is provisioned for use by each slice of the storage device engine. The shared slice memory is a portion of total storage device engine memory. Each slice's access to the shared memory portion is controlled.

Abstract: A nanobody and its application based on SARS-CoV-2 S protein are provided, and the present disclosure relates to biomedical technology. The present disclosure chooses the Spike S1+S2 ECD of SARS-CoV-2 as a target, and screens the nanobody against of SARS-CoV-2 by using a nanobody library. After an ELISA test, the Spike S1+S2 ECD target of SARS-CoV-2 can be specifically identified while a SPIKE RBD target is identified, and a binding signal is relatively strong. The corresponding nanobody sequence is constructed into a prokaryotic expression vector for expression and purification to express the target nanobody successfully. After the purification, the purity is greater than 90%. The ELISA test of VHH nanobody showed that the purified nanobody has higher affinity to the two targets.

Abstract: A computing method is provided. The computing method includes: obtaining a plurality of first fixed point numbers and a plurality of first exponents that correspond to the plurality of first floating point numbers, and a plurality of second fixed point numbers and a plurality of second exponents that correspond to the plurality of second floating point numbers; obtaining a fixed point product of each of the plurality of first fixed point numbers and a second fixed point number corresponding to the first fixed point number, and a corresponding fixed point product exponent; obtaining a fixed point inner product calculation result of the first vector and the second vector; and obtaining, based on the fixed point inner product calculation result, a floating point inner product calculation result in a floating point data format corresponding to the fixed point inner product calculation result.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may avoid frequent handover in small cells by triggering handover to a macro cell. The UE may determine that the UE performs a number of handovers within a time period. The UE may determine to trigger a handover to the macro cell. The UE may identify the macro cell based on measuring the macro cell during multiple handovers. The UE may determine to refrain from indicating signal measurements of small cells in a measurement report. Accordingly, a measurement report may include a signal measurement of the macro cell and omit the signal measurements of the small cells. The UE may transmit the measurement report to the small cell acting as a serving cell for the UE. Based the measurement report, the UE may receive a message initiating a handover procedure with the macro cell.

Abstract: Provided herein are engineered cells, comprising: a chemical or biological moiety covalently bound to a cell surface glycan, wherein the chemical or biological moiety is selected from the group consisting of small molecule, polynucleotide, polypeptide, and antibody. Also provided are compositions comprising these engineered cells and methods of making and using the same.

Abstract: Data deduplication techniques may use a fingerprint hash table and a backend location hash table in connection with performing operations including fingerprint insertion, fingerprint deletion and fingerprint lookup. Processing I/O operations may include: receiving a write operation that writes data to a target logical address; determining a fingerprint for the data; querying the fingerprint hash table using the fingerprint to determine a matching entry of the fingerprint hash table for the fingerprint; and responsive to determining that the fingerprint hash table does not have the matching entry that matches the fingerprint, performing processing including: inserting a first entry in the fingerprint hash table, wherein the first entry includes the fingerprint for the data and identifies a storage location at which the data is stored; and inserting a second entry in a backend location hash table, wherein the second entry references the first entry.

Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Abstract: An e-gaming entertainment system includes a central control platform, a plurality of light devices and a plurality of audio devices. The central control platform receives light adjustment instructions or sound adjustment instructions, converts the light adjustment instructions or the sound adjustment instructions into light adjustment execution commands or sound adjustment execution commands, and sends the light adjustment execution commands or the sound adjustment execution commands through a wired or wireless way forward to the light devices or audio devices correspondingly. The light devices receive the light adjustment execution commands and perform light adjustment operations. The audio devices receive the sound adjustment execution commands and perform sound adjustment operations. The e-gaming entertainment system is efficient and convenient. The central control platform controls multiple light devices and audio devices in a wireless or wired manner.

Abstract: A high-throughput screening methods for identifying candidate anticancer medicinal agents is described herein. The candidate anticancer medicinal agents are arylfluorosulfate compounds derived from phenolic compounds. The method involves in situ generation of the arylfluorosulfate compounds in multi-well plates by reaction of phenolic compounds in DMSO with a saturated solution of SO2F2 dissolved in a solvent such as acetonitrile, in the presence of an organic base, followed by reaction of generated fluoride ion with trimethylsilanol to form volatile trimethylsilyl fluoride. Solvents, organic base, and silyl compounds are then removed, in vacuo, to afford the arylfluorosulfate compounds suitable for biological screening in cancer cell lines without further purification.

Abstract: A receiving device re-establishing a packet data convergence protocol (PDCP) entity. The receiving device resets a robust header compression (ROHC) context. The receiving device receives packet retransmissions having header compression based on the ROHC. The receiving device performs decompression of the packet retransmissions. The receiving device discards duplicate packets after performing the decompression of the packet retransmissions.

Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Abstract: A cross-coupled tunnel diode (XTD) device with large peak-to-valley current ratio (PVCR) is disclosed. A memory cell circuit comprising XTD devices is also disclosed. The XTD device includes an N-type semiconductor coupled to a P-type semiconductor. A first gate is disposed on the N-type semiconductor and a second gate is disposed on the P-type semiconductor. The first gate is coupled to the output terminal, which is further coupled to the P-type semiconductor. The second gate is coupled to the input terminal, which is coupled to the N-type semiconductor. As reverse bias voltage increases, band-to-band tunneling from valence band to conduction band initially generates increasing current, but the rising bias voltage closes the band to band tunneling window, creating a gated negative differential resistance behavior. The current drops off as the bias voltage further increases. In some examples, a ratio of peak-to-valley current ratio may exceed 103 or 105.

Abstract: An information extraction method includes: determining that a text block that belongs to a target category and that is in text with layout is to be extracted; recognizing, based on feature information at a text block granularity, the text block that belongs to the target category and that is in the text with layout; and outputting an identifier of the text block that belongs to the target category and that is in the text with layout.

Abstract: Various implementations provide 3D representations of objects. Such representations may be based on 3D point cloud and/or 2D image inputs that are obtained based on sensor data, e.g., images, depth data, motion data, etc. 3D point cloud input may be used for part segmentation and/or to determine position and/or orientation of object parts, e.g., generating 3D bounding boxes representing the sizes, positions, and orientations, of object parts. 2D image input may be used for part attribute recognition, e.g., to determine whether a chair legs part has a particular type such as star-shaped, straight down, crossed-shaped, etc. Part attributes may be used to produce a relatively simple and relatively accurate representation of the shape of each part within a respective area, e.g., within a bounding box determined for each part using the 3D point cloud input.

Abstract: Aspects of the present disclosure relate to data cache management. In embodiments, a logical block address (LBA) bucket is established with at least one logical LBA group. Additionally, at least one LBA group is associated with two or more distinctly sized cache slots based on an input/output (IO) workload received by the storage array. Further, the association includes binding the two or more distinctly sized cache slots with at least one LBA group and mapping the bound distinctly sized cache slots in a searchable data structure. Furthermore, the searchable data structure identifies relationships between slot pointers and key metadata.