Abstract: Provided herein are nanoparticle assembled (NPA) coacervates, the nanoparticles of which each include a hydrophobic core and a plurality of hydrophilic polymeric chains extending from the hydrophobic core. The hydrophilic chains include functional end groups capable of non-covalent interactions with one another upon assembly of the nanoparticles into the coacervates. Also provided are methods for forming the coacervates, reversibly switching the physiological states of the coacervates, transiently activating macromolecular uptake by the coacervates, and administering the coacervates to a subject.

Abstract: The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to each other as well as to solid surface, including the making of adhesive materials such as hydrogels.

Abstract: The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to each other as well as to solid surface, including the making of adhesive materials such as hydrogels.