Patents by Inventor Pengzu Zhou

Pengzu Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making a solid-state form of AMG 706
    Patent number: 8648199
    Abstract: The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: February 11, 2014
    Assignee: Amgen Inc.
    Inventors: Belle Bei Liu, Nina Cauchon, Gonzalo Alva, Pengzu Zhou
  • PROCESS FOR MAKING A SOLID-STATE FORM OF AMG 706
    Publication number: 20130317227
    Abstract: The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 28, 2013
    Applicant: Amgen Inc.
    Inventors: Belle Bei Liu, Nina Cauchon, Gonzalo Alva, Pengzu Zhou
  • Methods and compositions for making and using polymorphs of cinacalcet
    Patent number: 8415501
    Abstract: The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: April 9, 2013
    Assignee: Amgen, Inc.
    Inventors: Belle B. Liu, Pengzu Zhou, Nina Cauchon
  • SOLID-STATE FORM OF AMG 706 AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20100331548
    Abstract: The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention.
    Type: Application
    Filed: September 3, 2010
    Publication date: December 30, 2010
    Applicant: Amgen Inc.
    Inventors: Belle B. Liu, Gonzalo Alva, Nina Cauchon, Seshadri Neervannan, Pengzu Zhou
  • Solid-state form of AMG 706 and pharmaceutical compositions thereof
    Publication number: 20080108664
    Abstract: The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention.
    Type: Application
    Filed: December 7, 2006
    Publication date: May 8, 2008
    Inventors: Belle B. Liu, Gonzalo Alva, Nina Cauchon, Seshadri Neervannan, Pengzu Zhou
  • Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
    Patent number: 7361789
    Abstract: The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: April 22, 2008
    Assignee: Amgen Inc.
    Inventors: Qi Yan, Carlos Orihuela, Bo Shen, Ying Chen, Xin Wang, John Ng, Ruizhi Ji, Pengzu Zhou
  • METHODS AND COMPOSITIONS FOR MAKING AND USING POLYMORPHS OF CINACALCET
    Publication number: 20070238790
    Abstract: The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.
    Type: Application
    Filed: March 22, 2007
    Publication date: October 11, 2007
    Applicant: AMGEN INC.
    Inventors: Belle Liu, Pengzu Zhou, Nina Cauchon