Patents by Inventor Pennina R. Langer

Pennina R. Langer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified nucleotides and polynucleotides and complexes form therefrom
    Patent number: 5476928
    Abstract: Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: December 19, 1995
    Assignee: Yale University
    Inventors: David C. Ward, Pennina R. Langer, Alexander A. Waldrop, III
  • Modified polynucleotides and methods of preparing same
    Patent number: 5449767
    Abstract: Compounds having the structure: ##STR1## wherein B represents 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1 '-position of the sugar moiety, provided that when B is 7-deazapurine, it is attached at the N.sup.9 -position of the 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.1 -position;wherein A represents a moiety consisting of at least three carbon atoms which is capable of forming a detectable complex with a polypeptide when the compound is incorporated into a double-stranded ribonucleic acid, deoxyribonucleic acid duplex, or DNA-RNA hybrid;wherein the dotted line represents a chemical linkage joining B and A, provided that if B is 7-deazapurine, the linkage is attached to the 7-position of the deazapurine, and if B is pyrimidine, the linkage is attached to the 5-position of the pyrimidine; andwherein each of x, y and z represents ##STR2## either directly, or when incorporated into oligo- and polynucleotides, provide probes which are widely useful.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: September 12, 1995
    Assignee: Yale University
    Inventors: David C. Ward, Pennina R. Langer, Alexander A. Waldrop, III
  • Methods of using labeled nucleotides
    Patent number: 5328824
    Abstract: Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: July 12, 1994
    Assignee: Yale University
    Inventors: David C. Ward, Pennina R. Langer, Alexander A. Waldrop, III
  • Modified nucleotides and methods of preparing and using same
    Patent number: 4711955
    Abstract: Compounds having the structure: ##STR1## wherein B represents a purine, 7-deazapurine, or pyrimidine moiety covalently bonded to the C.sup.1' -position of the sugar moiety, provided that when B is purine or 7-deazapurine, it is attached at the N.sup.9 -position of the purine or 7-deazapurine and when B is pyrimidine, it is attached at the N.sup.
    Type: Grant
    Filed: May 23, 1983
    Date of Patent: December 8, 1987
    Assignee: Yale University
    Inventors: David C. Ward, Pennina R. Langer, Alexander A. Waldrop, III