Patents by Inventor Per Franklin Nielsen

Per Franklin Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of GLP-1 analogs
    Patent number: 8097698
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: January 17, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Soren Erik Bjorn, Freddy Zimmerdahl Pedersen, Kjeld Madsen
  • GLP-1 Derivatives II
    Publication number: 20110053839
    Abstract: The present invention relates to a derivative of GLP-1(7-C), wherein C is 35 or 36 which derivative has just one lipophilic substituent which is attached to the C-terminal amino acid residue.
    Type: Application
    Filed: August 23, 2010
    Publication date: March 3, 2011
    Applicant: NOVO NORDISK A/S
    Inventors: LISELOTTE BJERRE KNUDSEN, PER OLAF HUUSFELDT, PER FRANKLIN NIELSEN, KJELD MADSEN
  • Novel Prolactin Compounds
    Publication number: 20100292444
    Abstract: The present invention relates to prolactin analogues, which analogues have increased resistance to deamidation.
    Type: Application
    Filed: July 3, 2008
    Publication date: November 18, 2010
    Applicant: Novo Nordisk A/S
    Inventors: Jens Breinholt, Per Franklin Nielsen, Leif Christensen, Leif Nørskov-Lauritsen, Anders Swensson
  • Derivatives Of GLP-1 Analogs
    Publication number: 20090176700
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Application
    Filed: November 26, 2007
    Publication date: July 9, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Soren Erik Bjorn, Freddy Zimmerdahl Pedersen, Kjeld Madsen
  • Human Spasmolytic Polypeptide in Glycosylated Form
    Publication number: 20090011461
    Abstract: Human spasmolytic polypeptide (HSP) which has the amino acid sequence Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyr or a functionally equivalent homologue thereof, characterized by being in glycosylated form.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 8, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Lars Thim, Kjeld Norris, Fanny Norris, Soren Erik Bjorn, Mogens Christensen, Per Franklin Nielsen
  • Human Spasmolytic Polypeptide in Glycosylated Form
    Publication number: 20080274964
    Abstract: Human spasmolytic polypeptide (HSP) which has the amino acid sequence Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyr or a functionally equivalent homologue thereof, characterized by being in glycosylated form.
    Type: Application
    Filed: February 29, 2008
    Publication date: November 6, 2008
    Applicant: NOVO NORDISK A/S
    Inventors: Lars Thim, Kjeld Norris, Fanny Norris, Soren Erik Bjorn, Mogens Christensen, Per Franklin Nielsen
  • GLP-1 derivatives II
    Publication number: 20080103097
    Abstract: The present invention relates to a derivative of GLP-1(7-C), wherein C is 35 or 36 which derivative has just one lipophilic substituent which is attached to the C-terminal amino acid residue.
    Type: Application
    Filed: April 26, 2007
    Publication date: May 1, 2008
    Applicant: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Kjeld Madsen
  • Derivatives of GLP-1 analogs
    Patent number: 7235627
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: June 26, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudson, Per Olaf Huusfeldt, Per Franklin Nielsen
  • Extendin derivatives
    Patent number: 7226990
    Abstract: The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of the derivative.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: June 5, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Kjeld Madsen
  • GLP-2 derivatives
    Publication number: 20040127418
    Abstract: Analogs of GLP-2, pharmaceutical compositions comprising GLP-2 analogs, and methods of treating diseases and disorders comprising administering such analogs or compositions are provided.
    Type: Application
    Filed: December 8, 2003
    Publication date: July 1, 2004
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Lars Thim, Soren Erik Bjorn
  • Derivatives of GLP-1 analogs
    Publication number: 20030199672
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Application
    Filed: August 19, 2002
    Publication date: October 23, 2003
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Soren Erik Bjorn, Freddy Zimmerdahl Pedersen, Kjeld Madsen
  • Human spamolytic polypeptide in glycosylated form
    Publication number: 20030077696
    Abstract: A human spasmolytic polypeptide (HSP) having the amino acid SEQ ID NO:1, characterized by being in a glycosylated form.
    Type: Application
    Filed: March 20, 2000
    Publication date: April 24, 2003
    Inventors: Lars Thim, Kjeld Norris, Fanny Norris, Soren Bjorn, Mogens Christensen, Per Franklin Nielsen
  • Analogues and derivatives of gastrin releasing peptide (GRP)
    Publication number: 20020165148
    Abstract: The present invention relates to analogues and derivatives of GRP which have a protracted profile of action, as well as their use in treatment of e.g. Type 2 diabetes and obesity.
    Type: Application
    Filed: November 16, 2001
    Publication date: November 7, 2002
    Inventors: Per Franklin Nielsen, Ulla Ribel-Madsen, Peter Andreas Nicolai Reumert Wagtmann
  • Derivatives of GLP-1 analogs
    Patent number: 6458924
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: October 1, 2002
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen
  • GLP-2 derivatives
    Publication number: 20020025933
    Abstract: The present invention relates to derivatives of hGLP-2 and analogues and/or fragments thereof having a lipophilic substituent have interesting pharmacological properties, in particular they have a more protracted profile of action than the parent peptides.
    Type: Application
    Filed: July 18, 2001
    Publication date: February 28, 2002
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Lars Thim, Soren Erik Bjorn
  • Extendin derivatives
    Publication number: 20010047084
    Abstract: The present invention relates to a derivative of GLP-1 (7-C), wherein C is 35 or 36 which derivative has just one lipophilic substituent which is attached to the C-terminal amino acid residue.
    Type: Application
    Filed: June 21, 2001
    Publication date: November 29, 2001
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Kjeld Madsen
  • DERIVATIVES OF GLP-1 ANALOGS
    Publication number: 20010011071
    Abstract: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
    Type: Application
    Filed: September 16, 1999
    Publication date: August 2, 2001
    Inventors: LISELOTTE BJERRE KNUDSEN, PER OLAF HUUSFELDT, PER FRANKLIN NIELSEN, NIELS C. KAARSHOLM, HELLE BIRK OLSEN, SOREN ERIK BJORN, FREDDY ZIMMERDAHL PEDERSEN, KJELD MADSEN
  • Derivatives of GLP-1 analogs
    Patent number: 6268343
    Abstract: The present invention relates to GLP-1 derivatives having a lipophilic substituent, pharmaceutical compositions comprising same, and methods of making an using same. The GLP-1 derivatives of the present invention have a protracted profile of action.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: July 31, 2001
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Per Olaf Huusfeldt, Per Franklin Nielsen, Niels C. Kaarsholm, Helle Birk Olsen, Søren Erik Bjørn, Freddy Zimmerdahl Pedersen, Kjeld Madsen
  • Human spasmolytic polypeptide in glycosylated form
    Patent number: 5783416
    Abstract: A human spasmolytic polypeptide (HSP) having the amino acid of SEQ ID NO:1, characterized by being in a glycosylated form.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: July 21, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Lars Thim, Kjeld Norris, Fanny Norris, S.o slashed.ren Erik Bj.o slashed.rn, Mogens Christensen, Per Franklin Nielsen