Patents by Inventor Periklis Pantazis
Periklis Pantazis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210356396Abstract: The present invention refers to Biodegradable, biocompatible, water-suspensable nanoparticle (1), for generating a second- or third-harmonic light signal upon illumination, as well as a method for preparing an aqueous suspension comprising said nanoparticle, a method for second-harmonic generation imaging of the nanoparticle (1) as and a use of the nanoparticle (1) for second-harmonic generation imaging. The nanoparticle (1) according to the invention comprises —a shell layer (2) comprising a biodegradable polymer (3), wherein the shell layer (2) encloses —a plurality (40) of oligopeptides (4), wherein the plurality (40) of oligopeptides (4) is structured such that a second-harmonic light signal is generated upon illumination of the nanoparticle (1) with light.Type: ApplicationFiled: September 28, 2017Publication date: November 18, 2021Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V., ETH ZÜRICHInventors: Periklis PANTAZIS, Ali Yasin SONAY, Daniel CRESPY, Katharina LANDFESTER
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Method and device to achieve spatially confined photointeraction at the focal volume of a microscope
Patent number: 9971136Abstract: The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).Type: GrantFiled: March 20, 2014Date of Patent: May 15, 2018Assignees: ETH ZÜRICH, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Periklis Pantazis, William P. Dempsey, Thai V. Truong, Scott E. Fraser, Lada Georgieva -
Patent number: 9897587Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: GrantFiled: October 24, 2016Date of Patent: February 20, 2018Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
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Publication number: 20170082596Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: ApplicationFiled: October 24, 2016Publication date: March 23, 2017Applicant: California Institute of TechnologyInventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
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Patent number: 9476830Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: GrantFiled: November 21, 2007Date of Patent: October 25, 2016Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
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Patent number: 9352055Abstract: Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: GrantFiled: September 10, 2015Date of Patent: May 31, 2016Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Jelena Culic-Viskota, William P. Dempsey, Scott E. Fraser
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Publication number: 20160051705Abstract: Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: ApplicationFiled: September 10, 2015Publication date: February 25, 2016Inventors: Periklis Pantazis, Jelena Culic-Viskota, Wiliam P. Dempsey, Scott E. Fraser
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METHOD AND DEVICE TO ACHIEVE SPATIALLY CONFINED PHOTOINTERACTION AT THE FOCAL VOLUME OF A MICROSCOPE
Publication number: 20160054553Abstract: The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system, comprising two or more laser light sources (41, 42) emitting light (32, 34) of different wavelengths adapted to excite a material in an identical number of independent excitation steps to a higher vibrational state from which the material relaxes, either emitting a conversion light to be detected (“photoexcitation”) or modulating the spectral properties of the material (“photomodulation”).Type: ApplicationFiled: March 20, 2014Publication date: February 25, 2016Inventors: Periklis PANTAZIS, william P. DEMPSEY, Thai V. TRUONG, Scott E. FRASER, Lada GEORGIEVA -
Patent number: 9221919Abstract: Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: GrantFiled: November 21, 2012Date of Patent: December 29, 2015Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Jelena Culic-Viskota, William P. Dempsey, Scott E. Fraser
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Patent number: 8945471Abstract: Second harmonic nanoprobes for multipurpose imaging of samples and a method of using such probes to monitor nucleotide sequencing in a Multi-SHG Detection Imaging (MSDI) modality and to monitor external electric field using voltage sensitive second harmonic generating (SHG) nanoprobes are provided. The SHG nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging for a wide-range of biological and non-biological processes and devices.Type: GrantFiled: January 20, 2010Date of Patent: February 3, 2015Assignee: California Institute of TechnologyInventors: Periklis Pantazis, Sotirios Masmanidis, Scott E. Fraser
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Publication number: 20120141981Abstract: Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.Type: ApplicationFiled: November 21, 2007Publication date: June 7, 2012Inventors: Periklis Pantazis, Ye Pu, Demetri Psaltis, John H. Hong, Scott E. Fraser
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Publication number: 20100233820Abstract: Second harmonic nanoprobes for multipurpose imaging of samples and a method of using such probes to monitor nucleotide sequencing in a Multi-SHG Detection Imaging (MSDI) modality and to monitor external electric field using voltage sensitive second harmonic generating (SHG) nanoprobes are provided. The SHG nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging for a wide-range of biological and non-biological processes and devices.Type: ApplicationFiled: January 20, 2010Publication date: September 16, 2010Applicant: California Institute of TechnologyInventors: Periklis Pantazis, Sotirios Masmanidis, Scott E. Fraser