Patents by Inventor Perrine Vasseur
Perrine Vasseur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10858675Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized production of 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.Type: GrantFiled: April 7, 2016Date of Patent: December 8, 2020Assignee: METABOLIC EXPLORERInventors: Wanda Dischert, Laurence Dumon-Seignovert, Perrine Vasseur, Gwénaëlle Bestel-Corre, Philippe Soucaille
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Patent number: 10329591Abstract: The present invention is related to a recombinant microorganism optimized for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine efflux is enhanced by overexpressing the homologous logous genes of ygaZ and ygaH genes from Escherichia coli. It is also related to a method for optimizing the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine efflux is enhanced by overexpressing the ygaZH homologous genes of ygaZ and ygaH genes from Escherichia coli, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.Type: GrantFiled: August 31, 2015Date of Patent: June 25, 2019Assignee: Evonik Degussa GmbHInventors: Rainer Figge, Laurence Dumon-Seignovert, Perrine Vasseur, Wanda Dischert
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Patent number: 10196658Abstract: The present application is related to a recombinant microorganism optimized for the fermentative production of methionine and/or its derivatives, wherein in said recombinant microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced. The application is also related to a method for optimizing the fermentative production of methionine and/or its derivatives comprising the steps of: c. culturing a recombinant microorganism wherein in said microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and d. recovering methionine and/or its derivatives from the culture medium.Type: GrantFiled: September 1, 2014Date of Patent: February 5, 2019Assignee: EVONIK DEGUSSA GMBHInventors: Wanda Dischert, Perrine Vasseur, Rainer Figge
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Publication number: 20180223319Abstract: The present invention relates to a recombinant microorganism useful for the production of L-methionine and process for the preparation of L-methionine. The microorganism of the invention is modified in a way that the L-methionine production is improved by using a thiocarboxylated protein as sulfur donor and by expressing an enzyme having homoserine O-acetyltransferase activity without feedback inhibition by methionine and/or S-adenosylmethionine and an enzyme having O-acetylhomoserine sulfhydrylase activity.Type: ApplicationFiled: August 7, 2015Publication date: August 9, 2018Applicant: Evonik Degussa GmbHInventors: Philippe SOUCAILLE, Perrine VASSEUR
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Patent number: 9988655Abstract: The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.Type: GrantFiled: July 11, 2017Date of Patent: June 5, 2018Assignee: EVONIK DEGUSSA GMBHInventors: Rainer Figge, Perrine Vasseur
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Publication number: 20180105845Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.Type: ApplicationFiled: April 7, 2016Publication date: April 19, 2018Applicant: METABOLIC EXPLORERInventors: Wanda DISCHERT, Laurence DUMON-SEIGNOVERT, Perrine VASSEUR, Gwénaëlle BESTEL-CORRE, Philippe SOUCAILLE
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Publication number: 20170306366Abstract: The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.Type: ApplicationFiled: July 11, 2017Publication date: October 26, 2017Applicant: EVONIK DEGUSSA GMBHInventors: Rainer FIGGE, Perrine VASSEUR
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Publication number: 20170240938Abstract: The present invention is related to a recombinant microorganism optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine efflux is enhanced by overexpressing the homologous logous genes of ygaZ and ygaH genes from Escherichia coli. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine efflux is enhanced by overexpressing the ygaZH homologous genes of ygaZ and ygaH genes from Escherichia coli, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.Type: ApplicationFiled: August 31, 2015Publication date: August 24, 2017Applicant: METABOLIC EXPLORERInventors: Rainer FIGGE, Laurence DUMON-SEIGNOVERT, Perrine VASSEUR, Wanda DISCHERT
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Patent number: 9732364Abstract: The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.Type: GrantFiled: December 13, 2010Date of Patent: August 15, 2017Assignee: EVONIK DEGUSSA GMBHInventors: Rainer Figge, Perrine Vasseur
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Publication number: 20160177352Abstract: The present application is related to a recombinant microorganism optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced. The application is also related to a method for optimizing the fermentative production of methionine and/or its derivatives comprising the steps of: c. culturing a recombinant microorganism wherein in said microorganism, the cobalamin-dependent methionine synthase activity and the methionine efflux are enhanced, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and d. recovering methionine and/or its derivatives from the culture medium.Type: ApplicationFiled: September 1, 2014Publication date: June 23, 2016Applicant: METABOLIC EXPLORERInventors: Wanda DISCHERT, Perrine VASSEUR, Rainer FIGGE
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Patent number: 9034611Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.Type: GrantFiled: October 24, 2011Date of Patent: May 19, 2015Assignee: METALBOLIC EXPLORERInventors: Wanda Dischert, Perrine Vasseur, Cédric Boisart, Rainer Figge
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Publication number: 20130183727Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.Type: ApplicationFiled: October 24, 2011Publication date: July 18, 2013Applicant: METABOLIC EXPLORERInventors: Wanda Dischert, Perrine Vasseur, Cedric Boisart, Rainer Figge
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Publication number: 20120252077Abstract: The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the production of methionine, its precursors or derivatives in a fermentative process comprising the following steps: culturing a modified microorganism in an appropriate culture medium comprising a source of carbon, a source of sulphur and a source of nitrogen, and recovering methionine and/or its derivatives from the culture medium, wherein in said modified microorganism, the expression of at least one gene involved in methionine production is under the control, direct or indirect, of a heterologous inducible promoter. The invention also concerned the modified microorganism used in the method.Type: ApplicationFiled: December 13, 2010Publication date: October 4, 2012Applicant: METABOLIC EXPLORERInventors: Rainer Figge, Perrine Vasseur