Abstract: A system for managing advertisements in an in-flight entertainment (“IFE”) system operating on an airplane can include an inventory processing device and a non-transitory computer readable medium. The non-transitory computer readable medium can be communicatively coupled to the inventory processing device to cause the inventory processing device to perform operations. The operations can include determining an inventory of targeted advertisements for future flights. The operations can further include receiving a request to use a portion of the inventory for advertisements associated with an advertiser. The operations can further include transmitting instructions to an IFE controller on-board the airplane to cause the IFE controller to provide the advertisements during targeted advertisement opportunities during a flight.

Abstract: The present disclosure provides a bidirectional power converter capable of receiving and delivering AC and DC power from and to multiple ports in accordance to its different embodiments. The AC or DC input receives power and at least two power conversion circuits work with a plurality of switches for connecting provides DC or AC current at multiple ports. The power conversion circuits may be rectifier inverters and have module form that connect to the AC and DC ports via a backplane having multiple connectors. The apparatus may also provide DC to DC conversion using a buck/boost circuit.

Abstract: A method (100) for disinfection using a lighting system (200), comprising: •determining (140) a mid-infrared (IR) and/or far-IR wavelength configured to disrupt a target macromolecule of a target pathogen, wherein the target macromolecule is DNA, RNA, and/or •a protein of the target pathogen; and exposing (150), via a light source (210) of the lighting system (200), •exposing (150), via a light source of the lighting system (200), the target pathogen to the determined mid-IR and/or far-IR wavelength, wherein the target macromolecule is directly disrupted and the target pathogen is neutralized by the exposure; and •detecting (160), by a sensor (224) of the lighting system (200), neutralisation of the target pathogen by exposure.

Abstract: A method, device and system for providing user-centric connections to a location comprising digital collaboration tools, as well as software for carrying out the method. The method includes a network device having a beacon system for proximity detection and a BYOD (Bring Your Own Device). A confirmed BYOD proximity can be used to initiate the setup of a data channel between the network device and the BYOD, and further join the BYOD to a UC (Unified Communications systems and tools) session.

Abstract: The invention pertains to a complex of an OMV, a vertebrate antimicrobial peptide (AMP) and an antigen, wherein the AMP is non-covalently complexed with the OMV and wherein the antigen is conjugated to the AMP. Preferably, the antigen is covalently linked to the AMP. The invention further concerns the induction of an immune response using the complex of the invention as well as a method for producing the complex of the invention.

Abstract: The present invention relates to neisserial LPS having a hexa-acylated lipid A moiety, wherein the hexa-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it comprises a palmitoleoyl instead of a lauroyl secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention further relates to mixtures of the hexa-acylated LPS with the corresponding penta-acylated LPS, lacking a secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention also relates to neisserial bacteria that have been genetically modified to reduce expression of the endogenous 1pxL1 gene and to introduce expression of a heterologous thermosensitive 1pxP gene for producing the hexa- and penta-acylated LPS.

Abstract: The present invention relates to neisserial LPS having a tetra-acylated lipid A moiety, wherein the tetra-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it lacks one of the secondary acyl chains and lacks a primary acyl chain on the 3-position of the glucosamine at the reducing end of the lipid A moiety. The invention further relates to neisserial bacteria that have been genetically modified to reduce expression of either one of the endogenous lpxL1 or lpxL2 genes and to introduce expression of a heterologous pagL gene. The neisserial LPS of the invention has TLR4 agonist properties and is therefore useful in compositions for inducing or stimulating immune responses, such as vaccines, as well as in other forms of immunotherapy.

Abstract: The present invention relates to neisserial LPS having a hexa-acylated lipid A moiety, wherein the hexa-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it comprises a palmitoleoyl instead of a lauroyl secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention further relates to mixtures of the hexa-acylated LPS with the corresponding penta-acylated LPS, lacking a secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention also relates to neisserial bacteria that have been genetically modified to reduce expression of the endogenous lpxL1 gene and to introduce expression of a heterologous thermosensitive lpxP gene for producing the hexa- and penta-acylated LPS.

Abstract: The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.

Abstract: The present invention relates to neisserial LPS having a tetra-acylated lipid A moiety, wherein the tetra-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it lacks one of the secondary acyl chains and lacks a primary acyl chain on the 3-position of the glucosamine at the reducing end of the lipid A moiety. The invention further relates to neisserial bacteria that have been genetically modified to reduce expression of either one of the endogenous lpxL1 or lpxL2 genes and to introduce expression of a heterologous pagL gene. The neisserial LPS of the invention has TLR4 agonist properties and is therefore useful in compositions for inducing or stimulating immune responses, such as vaccines, as well as in other forms of immunotherapy.

Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.

Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.

Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.

Abstract: The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.

Abstract: A tread for a tire includes a first circumferential groove extending in a circumferential direction entirely encircling the tire, the first circumferential groove having two sidewalls extending radially outward from an annular base, each sidewall defining a plane perpendicular to a rotational axis of the tire, and a first groove rib projecting radially outward from the annular base of the first circumferential groove, the first groove rib extending circumferentially and entirely encircling the tire, the first groove rib having two sidewalls extending radially outward from the annular base of the first circumferential groove to a radially outermost annular surface of the first groove rib, each sidewall of the first groove rib defining a plane perpendicular to a rotational axis of the tire, the sidewalls of the first circumferential groove extending circumferentially and parallel to the sidewalls of the first groove rib, the first groove rib having a radial height less than a radial height of the first circumfe

Abstract: A milking system includes a milking apparatus for milking of dairy animals, and a plurality of wearing parts, inclusive of teat liners and/or milk lines and/or pulsation lines. The system further includes a computer system configured to control and/or monitor the milking apparatus, and to generate a signal which indicates that one of the wearing parts should be replaced and provides a characterization of that wearing part. The milking system further includes a 3D printer operatively connected to the computer system and configured to print the characterized part on the basis of the generated signal. Thus it is not necessary to keep an unnecessarily large stock of spare parts, but it becomes possible to directly provide the spare parts quickly, cheaply and with less chance of errors. Moreover, it is thus possible to tailor the parts, especially teat liners, to animals.

Abstract: A ceramic green wavelength conversion element (120) is coated with a red wavelength conversion material (330) and placed above a blue light emitting element (110) such that the ceramic element (120) is attached to the light emitting element (110), thereby providing an efficient thermal coupling from the red and green converters (330, 120) to the light emitting element (110) and its associated heat sink. To protect the red converter coating (330) from the effects of subsequent processes, a sacrificial clear coating (340) is created above the red converter element (330). This clear coating (340) may be provided as a discrete layer of clear material, or it may be produced by allowing the red converters to settle to the bottom of its suspension material, thereby forming a converter-free upper layer that can be subjected to the subsequent fabrication processes.

Abstract: The present invention relates to neisserial LPS having a hexa-acylated lipid A moiety, wherein the hexa-acylated lipid A moiety is modified as compared to the lipid A moiety of a wild-type neisserial LPS in that it comprises a palmitoleoyl instead of a lauroyl secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention further relates to mixtures of the hexa-acylated LPS with the corresponding penta-acylated LPS, lacking a secondary acyl chain on the glucosamine at the non-reducing end of the lipid A moiety. The invention also relates to neisserial bacteria that have been genetically modified to reduce expression of the endogenous lpxL1 gene and to introduce expression of a heterologous thermosensitive lpxP gene for producing the hexa- and penta-acylated LPS.

Abstract: A milking system includes a milking apparatus for milking of dairy animals, and a plurality of wearing parts, inclusive of teat liners and/or milk lines and/or pulsation lines. The system further includes a computer system configured to control and/or monitor the milking apparatus, and to generate a signal which indicates that one of the wearing parts should be replaced and provides a characterization of that wearing part. The milking system further includes a 3D printer operatively connected to the computer system and configured to print the characterized part on the basis of the generated signal. Thus it is not necessary to keep an unnecessarily large stock of spare parts, but it becomes possible to directly provide the spare parts quickly, cheaply and with less chance of errors. Moreover, it is thus possible to tailor the parts, especially teat liners, to animals.

Abstract: The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.