Patents by Inventor Peter B. Moore
Peter B. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150258092Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: November 25, 2014Publication date: September 17, 2015Applicants: YALE UNIVERSITY, MELINTA THERAPEUTICS, INC.Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Patent number: 8912150Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: June 21, 2013Date of Patent: December 16, 2014Assignees: Melinta Therapeutics, Inc., Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Publication number: 20140066623Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: June 21, 2013Publication date: March 6, 2014Inventors: THOMAS A. STEITZ, PETER B. MOORE, JOYCE A. SUTCLIFFE, ADEGBOYEGA K. OYELERE, JOSEPH A. IPPOLITO
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Patent number: 8470990Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: December 23, 2009Date of Patent: June 25, 2013Assignees: Rib-X Pharmaceuticals, Inc., Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Patent number: 8218710Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.Type: GrantFiled: January 13, 2012Date of Patent: July 10, 2012Assignee: Gary W. Clem, Inc.Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
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Patent number: 8175212Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.Type: GrantFiled: January 25, 2010Date of Patent: May 8, 2012Assignee: Gary W. Clem, Inc.Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
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Publication number: 20120106694Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.Type: ApplicationFiled: January 13, 2012Publication date: May 3, 2012Inventors: Brian W. CARR, Andrew G. JENKINS, Curtis R. HAMMER, Scott A. SPORRER, Adam R. KOESTERS, Edward J. PLIZGA, Peter B. MOORE
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Publication number: 20110182397Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.Type: ApplicationFiled: January 25, 2010Publication date: July 28, 2011Applicant: GARY W. CLEM, INC.Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
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Publication number: 20100312525Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: February 10, 2010Publication date: December 9, 2010Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen, Joseph A. Ippolito
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Publication number: 20100204253Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: December 23, 2009Publication date: August 12, 2010Applicants: Yale University, Rib-X Pharmaceuticals, Inc.Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Publication number: 20100131258Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: ApplicationFiled: July 22, 2008Publication date: May 27, 2010Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
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Patent number: 7666849Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: February 25, 2005Date of Patent: February 23, 2010Assignees: Rib-X Pharmaceuticals, Inc., Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
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Patent number: 7504486Abstract: The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).Type: GrantFiled: March 17, 2003Date of Patent: March 17, 2009Assignee: Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
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Patent number: 7398636Abstract: A wheel mounted grain harvester includes a harvesting head for depositing grain in a grain handling assembly comprised of a plurality of grain moving parts. Control means are located on the harvester for selectively interrupting grain flow along the grain moving parts causing harvested grain from a new separate row segment to temporarily accumulate. Means are provided for transporting the harvested grain from separate row segments into separate collection bins permit the separate evaluation of the harvested grain in each row segment. Means are provided for moving the harvester along the row at a constant rate of speed to avoid the necessity of stopping the harvester between row segments to effect the separate evaluation of the harvested grain. The selective interruption by the control means is accomplished by either interrupting at least one of the grain moving parts or by selectively closing a movable blocking wall mounted on the harvester.Type: GrantFiled: December 27, 2004Date of Patent: July 15, 2008Assignee: Gary W. Clem, Inc.Inventors: Brian W Carr, Donald F Handorf, Peter B Moore, Nick Merfeld, Scott A Sporrer, Curtis R Hammer, Gary W Clem
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Patent number: 7337733Abstract: A distance measuring device mounted to a planter used to plant crops. The distance measuring device has a cable extending between a first pulley and second pulley wherein the cable has at least one target. A sensor located adjacent the first pulley and connected to a controller sends a signal to the controller when the sensor detects the target. Adjacent the second pulley is an encoder that sends a second signal to the controller based upon the rotation of the second pulley such that the controller can determine the amount of distance that the planter has traveled.Type: GrantFiled: June 9, 2005Date of Patent: March 4, 2008Assignee: Gary W. Clem, Inc.Inventors: Brian W Carr, Scott A Sporrer, Donald F Handorf, Peter B Moore
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Patent number: 7111567Abstract: A seed meter for planting seeds includes a seed plate rotatably mounted within a housing. A rotary seed chamber (RSC) is mounted in the housing adjacent the seed plate and movable between first and second positions, to permit the seed plate to singularly select individual seeds from the RSC while in a first position, and to dump seed therefrom as well as blocking seeds from entering the seed plate while in a second position. A seed intake compartment having an inlet end, and a discharge end is located adjacent the RSC. A valve is located in the intake compartment to intermittently prevent seed from flowing from the inlet end to the discharge end. A power means actuates both the RSC and the valve. A wing plate on the rotary seed chamber opens and closes the discharge end as the rotary seed chamber is in its first and second positions, respectively.Type: GrantFiled: October 5, 2004Date of Patent: September 26, 2006Assignee: Gary W. Clem, Inc.Inventors: Brian W. Carr, Scott A. Sporrer, Donald F. Handorf, Nick Merfeld, Peter B. Moore
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Patent number: 6952650Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: February 8, 2002Date of Patent: October 4, 2005Assignee: Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen, Joseph A. Ippolito
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Patent number: 6947845Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: August 2, 2002Date of Patent: September 20, 2005Assignees: Yale University, Rib-X Pharmaceuticals, Inc.Inventors: Thomas A. Steitz, Peter B. Moore, Joseph A. Ippolito, Nenad Ban, Poul Nissen, Jeffrey L. Hansen
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Patent number: 6947844Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.Type: GrantFiled: August 3, 2001Date of Patent: September 20, 2005Assignee: Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
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Patent number: 6939848Abstract: The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).Type: GrantFiled: March 17, 2003Date of Patent: September 6, 2005Assignee: Yale UniversityInventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen