Patents by Inventor Peter B. Moore

Peter B. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150258092
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 17, 2015
    Applicants: YALE UNIVERSITY, MELINTA THERAPEUTICS, INC.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 8912150
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 16, 2014
    Assignees: Melinta Therapeutics, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20140066623
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: June 21, 2013
    Publication date: March 6, 2014
    Inventors: THOMAS A. STEITZ, PETER B. MOORE, JOYCE A. SUTCLIFFE, ADEGBOYEGA K. OYELERE, JOSEPH A. IPPOLITO
  • Patent number: 8470990
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: June 25, 2013
    Assignees: Rib-X Pharmaceuticals, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 8218710
    Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: July 10, 2012
    Assignee: Gary W. Clem, Inc.
    Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
  • Patent number: 8175212
    Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: May 8, 2012
    Assignee: Gary W. Clem, Inc.
    Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
  • Publication number: 20120106694
    Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 3, 2012
    Inventors: Brian W. CARR, Andrew G. JENKINS, Curtis R. HAMMER, Scott A. SPORRER, Adam R. KOESTERS, Edward J. PLIZGA, Peter B. MOORE
  • Publication number: 20110182397
    Abstract: A seed counting device where accuracy is maintained at higher counting rates. The seed counting device has a hopper in communication with a tray. An activator is connected to the tray to vibrate the tray. Connected to one end of the tray is a separator having sensors. Below the tray and in partial alignment with the separator is a projecting device. The projecting device projects seeds that fall from the tray past the sensors and into a seed chamber.
    Type: Application
    Filed: January 25, 2010
    Publication date: July 28, 2011
    Applicant: GARY W. CLEM, INC.
    Inventors: Brian W. Carr, Andrew G. Jenkins, Curtis R. Hammer, Scott A. Sporrer, Adam R. Koesters, Edward J. Plizga, Peter B. Moore
  • Publication number: 20100312525
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: February 10, 2010
    Publication date: December 9, 2010
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen, Joseph A. Ippolito
  • Publication number: 20100204253
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: December 23, 2009
    Publication date: August 12, 2010
    Applicants: Yale University, Rib-X Pharmaceuticals, Inc.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Publication number: 20100131258
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: July 22, 2008
    Publication date: May 27, 2010
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
  • Patent number: 7666849
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: February 23, 2010
    Assignees: Rib-X Pharmaceuticals, Inc., Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Patent number: 7504486
    Abstract: The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 17, 2009
    Assignee: Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
  • Patent number: 7398636
    Abstract: A wheel mounted grain harvester includes a harvesting head for depositing grain in a grain handling assembly comprised of a plurality of grain moving parts. Control means are located on the harvester for selectively interrupting grain flow along the grain moving parts causing harvested grain from a new separate row segment to temporarily accumulate. Means are provided for transporting the harvested grain from separate row segments into separate collection bins permit the separate evaluation of the harvested grain in each row segment. Means are provided for moving the harvester along the row at a constant rate of speed to avoid the necessity of stopping the harvester between row segments to effect the separate evaluation of the harvested grain. The selective interruption by the control means is accomplished by either interrupting at least one of the grain moving parts or by selectively closing a movable blocking wall mounted on the harvester.
    Type: Grant
    Filed: December 27, 2004
    Date of Patent: July 15, 2008
    Assignee: Gary W. Clem, Inc.
    Inventors: Brian W Carr, Donald F Handorf, Peter B Moore, Nick Merfeld, Scott A Sporrer, Curtis R Hammer, Gary W Clem
  • Patent number: 7337733
    Abstract: A distance measuring device mounted to a planter used to plant crops. The distance measuring device has a cable extending between a first pulley and second pulley wherein the cable has at least one target. A sensor located adjacent the first pulley and connected to a controller sends a signal to the controller when the sensor detects the target. Adjacent the second pulley is an encoder that sends a second signal to the controller based upon the rotation of the second pulley such that the controller can determine the amount of distance that the planter has traveled.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: March 4, 2008
    Assignee: Gary W. Clem, Inc.
    Inventors: Brian W Carr, Scott A Sporrer, Donald F Handorf, Peter B Moore
  • Patent number: 7111567
    Abstract: A seed meter for planting seeds includes a seed plate rotatably mounted within a housing. A rotary seed chamber (RSC) is mounted in the housing adjacent the seed plate and movable between first and second positions, to permit the seed plate to singularly select individual seeds from the RSC while in a first position, and to dump seed therefrom as well as blocking seeds from entering the seed plate while in a second position. A seed intake compartment having an inlet end, and a discharge end is located adjacent the RSC. A valve is located in the intake compartment to intermittently prevent seed from flowing from the inlet end to the discharge end. A power means actuates both the RSC and the valve. A wing plate on the rotary seed chamber opens and closes the discharge end as the rotary seed chamber is in its first and second positions, respectively.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: September 26, 2006
    Assignee: Gary W. Clem, Inc.
    Inventors: Brian W. Carr, Scott A. Sporrer, Donald F. Handorf, Nick Merfeld, Peter B. Moore
  • Patent number: 6952650
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: October 4, 2005
    Assignee: Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen, Joseph A. Ippolito
  • Patent number: 6947845
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: September 20, 2005
    Assignees: Yale University, Rib-X Pharmaceuticals, Inc.
    Inventors: Thomas A. Steitz, Peter B. Moore, Joseph A. Ippolito, Nenad Ban, Poul Nissen, Jeffrey L. Hansen
  • Patent number: 6947844
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: September 20, 2005
    Assignee: Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
  • Patent number: 6939848
    Abstract: The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: September 6, 2005
    Assignee: Yale University
    Inventors: Thomas A. Steitz, Peter B. Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen