Abstract: The present invention relates to methods and systems for the directed evolution of macromolecules. The methods involve increasing the mutation rate of an evolving organism comprising a gene of interest that encodes a gene product lacking a desired activity, whereby a mutated gene of interest is produced that encodes an evolved gene product comprising the desired activity and causing a suppression of mutagenesis. The systems comprise an evolving organism comprising a gene of interest encoding a gene product to be evolved, a host organism, and optionally, a lagoon, a cellstat and/or a suitable growth medium.

Abstract: The present invention relates to methods and systems for the directed evolution of macromolecules. The methods involve increasing the mutation rate of an evolving organism comprising a gene of interest that encodes a gene product lacking a desired activity, whereby a mutated gene of interest is produced that encodes an evolved gene product comprising the desired activity and causing a suppression of mutagenesis. The systems comprise an evolving organism comprising a gene of interest encoding a gene product to be evolved, a host organism, and optionally, a lagoon, a cellstat and/or a suitable growth medium.

Abstract: A pen-based system that automatically identifies either single page or multi-page forms when data is a written on paper copies of the form. The system captures pen stroke data as an untrained user fills out the paper form attached to its surface. The sequence and location of the raw pen-stroke data is analyzed to determine which form the user was filling out and which field on each page was the intended field for the subsets of stroke data. The form/field identification method allows the electronic clipboard to be used as if it were an ordinary clipboard. One of several single or multi-page forms in the selected, and attached to the clipboard without any special attention to its positioning. The user can fill out fields in any order skipping between pages at will, leaving fields blank, etc. and having no other interaction with the clipboard.

Abstract: A pen-based tablet computer system that locates objects in a collection of stored images by using partial tracing of a graphical data object. The system uses data generated from the partial tracing of the graphical object to control a search of the input data file for the most likely graphical object which is a match. When the most likely match is located, the input data page containing the matched image is determined. The system then may determine the page of form data that applies to the input data page that contains the graphical object and the correct input data page and form data page are simultaneously displayed on the computer display screen. The graphical object may be an image, text data, a line drawing, etc.

Abstract: A pen-based system that automatically identifies either single page or multi-page forms when data is a written on paper copies of the form. The system captures pen stroke data as an untrained user fills out the paper form attached to its surface. The sequence and location of the raw pen-stroke data is analyzed to determine which form the user was filling out and which field on each page was the intended field for the subsets of stroke data. The form/field identification method allows the electronic clipboard to be used as if it were an ordinary clipboard. One of several single or multi-page forms in the selected, and attached to the clipboard without any special attention to its positioning. The user can fill out fields in any order skipping between pages at will, leaving fields blank, etc. and having no other interaction with the clipboard.

Abstract: A virtual architecture for enabling direct point-to-point communications between any processes on a network cloud utilizes a process record in which information relevant to the process is stored and propagated through a parent/child hierarchy of connection service processes and information service processes. Process records and information relating to processes are propagated throughout private clouds, public clouds and interconnecting global services to facilitate both activity based network routing and load based network routing without the use of predetermined network routing mechanisms.

Abstract: This patent application describes a low-power electronic music synthesizer (1) which may be combined with a radio transmitter (2) for use in audio-kinetic sculptures or toys. The invention consists of a low-voltage circuit implementing a multiple voice analog music synthesizer utilizing digital CMOS invertors biased in their linear regions as push-pull amplifiers and field-effect transistors as parameter controlling elements. Because of the low-voltage operation, a charge-pump is required to produce a negative control voltage for the field-effect transistors. Variations in sound are produced by touching metal contacts (3,4,5,6,7,8,9,10) which are sensitive to the range of resistance and capacitance of human fingertips. The combination of low-voltage, low-power, high-fidelity sound generation and touch-sensitive controls make this ideal for a new kind of toy. Due to the low-voltage and low-power requirements, the circuit can operate for approximately forty hours using two 1.5 volt AA cells.