Patents by Inventor Peter Bosiger

Peter Bosiger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5247255
    Abstract: A sequence acts--preferably several times--upon an examination region, which sequence comprises two frequency-selective high-frequency pulses not exciting the water component, between which a 180.degree. high-frequency pulse is present. Such a sequence can be more insensitive to imperfections of the 180.degree. pulse in that the second frequency-selective high-frequency pulse is followed by a further frequency-selective high-frequency pulse not exciting the water component and in that between the second frequency-selective high frequency pulse and the further high-frequency pulse as well as after the further high-frequency pulse a magnetic gradient field is switched on and off in such a manner that the time integrals across this gradient field before and after the further high-frequency pulse are equal to each other.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: September 21, 1993
    Assignee: U.S. Philips Corp.
    Inventors: Graeme McKinnon, Peter Bosiger
  • Patent number: 5243285
    Abstract: Two-dimensional nuclear magnetic resonance spectroscopy with a frequently repeated sequence comprises four high-frequency pulses and acting together with a homogeneous stationary magnetic field upon an examination area, which sequence contains two 180.degree. pulses, halfway between which a third pulse is located. The pulse of the sequence are preceded by a first pulse, whose distance from the second pulse, which is equal to or larger than the relative distance of the other pulses, is varied during the repetition of the sequence. This method is particularly suitable for in vivo examinations of the human body in that during three of the four pulses magnetic gradient fields are operative, whose gradients extend mutually perpendicular to each other, and before and after the third high-frequency pulse a magnetic gradient field is operative having such a duration and such a gradient that the time integral across this field has the same value before the third pulse as after the third pulse.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: September 7, 1993
    Assignee: U.S. Philips Corp.
    Inventors: Graeme McKinnon, Peter Bosiger
  • Patent number: 5235278
    Abstract: A plurality of sequences act on an examination zone in the presence of a uniform, steady magnetic field, each of the sequences comprising at least three RF pulses which are preferably formed as 90.degree. pulses, applying between the second and the third RF pulse and after the third RF pulse magnetic gradient fields (G.sub.x) having an amplitude and a duration such that spin resonance signals occurring after the third RF pulse are determined exclusively by double quantum coherence. Thus, spatial and spectral determination of a lactate component is simultaneously possible when it is ensured that at least one magnetic gradient field is applied between or after the three RF pulses and when the time integral over at least one of these gradient fields is varied during repetition of the sequences, the second RF pulse (HF.sub.2) being frequency selective to reduce the lipid component (L.sub.1) near the lactate component (M.sub.1) so that the nuclear magnetization of the component (M.sub.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: August 10, 1993
    Assignee: U.S. Philips Corp.
    Inventors: Graeme McKinnon, Peter Bosiger
  • Patent number: 5160889
    Abstract: A magnetic resonance imaging method for high quality short echo time imaging uses FID-acquired-echoes. Gradient recalled echoes are excited in two short echo time acquisition sequences having opposite polarity reading gradients. Half-echoes for corresponding phase encoding steps are concatenated to reconstructed echoes. An image is reconstructed from the reconstructed echoes using a Fourier transform reconstruction method. With the method artefact free high quality images with echo times below 4 msec can be obtained, even under unfavorable conditions, such as fast blood flow.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: November 3, 1992
    Assignee: U.S. Philips Corporation
    Inventors: Markus B. Scheidegger, Peter Bosiger
  • Patent number: 5113138
    Abstract: In localized carbon MR spectroscopy, three slice selective pulses which influence the nuclear magnetization in only one slice are generated before a subsequence which is suitable for polarization transfer.
    Type: Grant
    Filed: April 10, 1990
    Date of Patent: May 12, 1992
    Assignee: U.S. Philips Corporation
    Inventors: Hartwin Bomsdorf, Graeme C. McKinnon, Peter Bosiger
  • Patent number: 5111143
    Abstract: A magnetic resonance spectroscopy method, and apparatus for performing the method, where a plurality of sequences act on an examination zone in the presence of a uniform, steady magnetic field, each sequence comprising at least three RF pulses, the distance between the first two RF pulses being equal to the reciprocal value of twice the scalar coupling constant J, between and after the pulses there being applied magnetic gradient fields having an amplitude and a duration such that the spin resonance signals occurring after the third RF pulse are determined exclusively by double quantum coherence. In order to suppress the fat component situated in the immediate vicinity of the lactate component of lower Larmor frequency, the lipid component at the area of the lactate component is reduced by making the second and/or the third RF pulse frequency-selective so that it acts as an 90.degree. pulse for the component coupled to the lactate component and as a 0.degree. pulse or 180.degree.
    Type: Grant
    Filed: August 3, 1990
    Date of Patent: May 5, 1992
    Assignee: U.S. Philips Corporation
    Inventors: Graeme McKinnon, Peter Bosiger
  • Patent number: 5034693
    Abstract: In the presence of a stationary homogeneous magnetic field a number of generated pulse sequences act on an object examination region, of which sequence each sequence comprises three 180.degree. high-frequency pulses following one another at the same temporal interval, which are preceded by at least one high-frequency pulse which produces a transverse magnetization. An apparatus for carrying out the method includes providing an echo time independent of the J-coupling of the object. The first and third of the three 180.degree. high-frequency pulses and the preceding high-frequency pulse are generated as slice-selective pulses, which excite three slices, the second 180.degree. high-frequency pulse is a frequency-selective pulse which is so shaped that it excites only one of two mutually coupled components of the object, and the nuclear resonance signal produced from the sectional area of the three slices is then processed in order to determine its spectrum.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: July 23, 1991
    Assignee: U.S. Philips Corporation
    Inventors: Graeme C. McKinnon, Peter Bosiger
  • Patent number: 4918387
    Abstract: MR spectroscopy method and apparatus in which an examination zone is exposed, preferably repeatedly, to a sequence which comprises a first binomial 90.degree. RF pulse, a 180.degree. RF pulse and a second binomial 90.degree. RF pulse which sequence enables separate demonstration of the presence of either lactic acid or lipids in the presence of water. The periods in time between the two binomial RF pulses and the 180.degree. RF pulse are equal and are approximately at least to the reciprocal value of four times the scalar coupling constant of lactic acid.
    Type: Grant
    Filed: November 21, 1988
    Date of Patent: April 17, 1990
    Assignee: U.S. Philips Corporation
    Inventors: Graeme C. McKinnon, Peter Bosiger
  • Patent number: 4868503
    Abstract: The invention relates to a volume selective magnetic resonance spectroscopy method. Volume selection is performed after excitation by means of three layer-selective 180.degree. rf pulses which excite the nuclear magnetization in three mutually perpendicular layers. The distance between the three selective 180.degree. rf pulses can be chosen to be as small as possible.
    Type: Grant
    Filed: July 26, 1988
    Date of Patent: September 19, 1989
    Assignee: U.S. Philips Corporation
    Inventors: Graeme C. McKinnon, Peter Bosiger
  • Patent number: 4862083
    Abstract: The invention relates to a method of generating a selective 180.degree. rf pulse is formed by means of two selective 90.degree. rf pulses. Halfway between the two rf pulses there is generated a non-selective 180.degree. rf pulse which ensures that the excited nuclear magnetization is independent of the homogeneity of the steady magnetic field of the magnetic resonance examination apparatus.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: August 29, 1989
    Assignee: U.S. Philips Corporation
    Inventors: Graeme C. McKinnon, Peter Bosiger