Abstract: The present application provides, in some aspects, methods of identifying a condensate of interest associated with a el disease. Also provided are methods of identifying a marker for identifying a condensate of interest associated with a disease. In other aspects, provided herein are methods of identifying a therapeutic agent useful for treating a disease via the identified condensate of interest.

Abstract: Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.

Abstract: The present invention provides biaxially oriented polystyrene composition film and container made of such biaxially oriented film. The films are useful in that they are clear and have improved room and low temperature impact strength. The films include from about 0.1 to about 1.4 weight percent rubber particles, based upon the total weight of the composition. The average diameters of the rubber particles are from about 0.1 micron to about 10 microns.

Abstract: The present invention provides film methods of using and methods of preparing a biaxially oriented polystyrene composition. The compositions are useful in that they are clear and have improved room and low temperature impact strength. The compositions include from about 0.1 to about 1.4 weight percent rubber particles, based upon the total weight of the composition. The average diameters of the rubber particles are from about 0.1 micron to about 10 microns.

Abstract: A sterilizable, plastic medical container has a body section formed of thin, multi layer film. The film has a first layer formed of cross-linkable plastic free or essentially free of extractable plasticizers, such as poly(ethylene vinyl acetate), and a second layer formed of a substantially non-cross-linkable plastic having a higher melting temperature than the first layer, such as high density polyethylene. The first layer is inwardly oriented in contact with the contents of the container. A port formed of the same plastic can be heat sealed to the body section. The container is irradiated to effect cross-linking, filled with fluid, and the port sealed. The fluid filled container can then be heat or steam sterilized.

Abstract: A sterilizable, plastic medical container has a body section formed of thin, multi layer film. The film has a first layer formed of cross-linkable plastic free or essentially free of extractable plasticizers, such as poly(ethylene vinyl acetate), and a second layer formed of a substantially non-cross-linkable plastic having a higher melting temperature than the first layer, such as high density polyethylene. The first layer is inwardly oriented in contact with the contents of the container. A port formed of the same plastic can be heat sealed to the body section. The container is irradiated to effect cross-linking, filled with fluid, and the port sealed. The fluid filled container can then be heat or steam sterilized.

Abstract: A plastic composition which may be molded into a connector which is capable of simultaneously sealing to both polyvinyl chloride plastics and polyolefin plastics. The plastic composition comprises from 50 to 75 percent by weight of an essentially polyolefin material which is sealingly compatible with the polyolefin plastic to which the composition is intended to be sealed, and from 25 to 50 percent by weight of a flexible block copolymer of covalently bonded polybutylene terephthalate units and poly(1,4-butylene) oxide units.

Abstract: A connector member for a fluid flow path is provided which comprises a transparent housing enclosing an opaque barrier membrane or wall portion blocking flow through the flow path. The barrier membrane is adapted to be openable by exposure to radiant energy from the exterior through the transparent housing. In accordance with this invention, the barrier membrane is made of a predominantly crystalline plastic material, and, accordingly, exhibits a relatively sharp melting point for improved opening characteristics upon exposure to the radiant energy.

Abstract: Flexible coextruded tubing having an outer portion (14) of polyvinyl chloride plastic containing a minor amount of intimately mixed silicone oil and having an inner portion (12) of plastic free of silicone oil.