Abstract: A superconducting readout system employing a microwave transmission line, and a microwave superconducting resonator communicatively coupled to the microwave transmission line, and including a superconducting quantum interference device (SQUID), may be advantageously calibrated at least in part by measuring a resonant frequency of the microwave superconducting resonator in response to a flux bias applied to the SQUID, measuring a sensitivity of the resonant frequency in response to the flux bias, and selecting an operating frequency and a sensitivity of the microwave superconducting resonator based at least in part on a variation of the resonant frequency as a function of the flux bias. The flux bias may be applied to the SQUID by an interface inductively coupled to the SQUID. Calibration of the superconducting readout system may also include determining at least one of a propagation delay, a microwave transmission line delay, and a microwave transmission line phase offset.

Abstract: An accelerated version of a node-weighted path distance algorithm is implemented on a microprocessor coupled to a digital processor. The algorithm calculates an embedding of a source graph into a target graph (e.g., hardware graph of a quantum processor). The digital processor causes the microprocessor to send seeds to logic blocks with a corresponding node in the target graph contained in a working embedding of a node, compute a minimum distance to neighboring logic blocks from each seeded logic block, set the distance to neighboring logic blocks as the minimum distance plus the weight of the seeded logic block, increment the accumulator value by the weight of the seeded logic block, increment the accumulator value by the distance, determine the minimum distance logic block by computing the minimum accumulated value, compute distances to the minimum distance logic block; and read distances from all logic blocks into local memory.

Abstract: A superconducting readout system employing a microwave transmission line, and a microwave superconducting resonator communicatively coupled to the microwave transmission line, and including a superconducting quantum interference device (SQUID), may be advantageously calibrated at least in part by measuring a resonant frequency of the microwave superconducting resonator in response to a flux bias applied to the SQUID, measuring a sensitivity of the resonant frequency in response to the flux bias, and selecting an operating frequency and a sensitivity of the microwave superconducting resonator based at least in part on a variation of the resonant frequency as a function of the flux bias. The flux bias may be applied to the SQUID by an interface inductively coupled to the SQUID. Calibration of the superconducting readout system may also include determining at least one of a propagation delay, a microwave transmission line delay, and a microwave transmission line phase offset.

Abstract: A superconducting input and/or output system employs at least one microwave superconducting resonator. The microwave superconducting resonator(s) may be communicatively coupled to a microwave transmission line. Each microwave superconducting resonator may include a first and a second DC SQUID, in series with one another and with an inductance (e.g., inductor), and a capacitance in parallel with the first and second DC SQUIDs and inductance. Respective inductive interfaces are operable to apply flux bias to control the DC SQUIDs. The second DC SQUID may be coupled to a Quantum Flux Parametron (QFP), for example as a final element in a shift register. A superconducting parallel plate capacitor structure and method of fabricating such are also taught.

Abstract: A superconducting input and/or output system employs at least one microwave superconducting resonator. The microwave superconducting resonator(s) may be communicatively coupled to a microwave transmission line. Each microwave superconducting resonator may include a first and a second DC SQUID, in series with one another and with an inductance (e.g., inductor), and a capacitance in parallel with the first and second DC SQUIDs and inductance. Respective inductive interfaces are operable to apply flux bias to control the DC SQUIDs. The second DC SQUID may be coupled to a Quantum Flux Parametron (QFP), for example as a final element in a shift register. A superconducting parallel plate capacitor structure and method of fabricating such are also taught.

Abstract: An electrical filter includes a dielectric substrate with inner and outer coils about a first region and inner and outer coils about a second region, a portion of cladding removed from wires that form the coils and coupled to electrically conductive traces on the dielectric substrate via a solder joint in a switching region. An apparatus to thermally couple a superconductive device to a metal carrier with a through-hole includes a first clamp and a vacuum pump. A composite magnetic shield for use at superconductive temperatures includes an inner layer with magnetic permeability of at least 50,000; and an outer layer with magnetic saturation field greater than 1.2 T, separated from the inner layer by an intermediate layer of dielectric. An apparatus to dissipate heat from a superconducting processor includes a metal carrier with a recess, a post that extends upwards from a base of the recess and a layer of adhesive on top of the post. Various cryogenic refrigeration systems are described.

Abstract: A superconducting input and/or output system employs at least one microwave superconducting resonator. The microwave superconducting resonator(s) may be communicatively coupled to a microwave transmission line. Each microwave superconducting resonator may include a first and a second DC SQUID, in series with one another and with an inductance (e.g., inductor), and a capacitance in parallel with the first and second DC SQUIDs and inductance. Respective inductive interfaces are operable to apply flux bias to control the DC SQUIDs. The second DC SQUID may be coupled to a Quantum Flux Parametron (QFP), for example as a final element in a shift register. A superconducting parallel plate capacitor structure and method of fabricating such are also taught.

Abstract: An electrical filter includes a dielectric substrate with inner and outer coils about a first region and inner and outer coils about a second region, a portion of cladding removed from wires that form the coils and coupled to electrically conductive traces on the dielectric substrate via a solder joint in a switching region. An apparatus to thermally couple a superconductive device to a metal carrier with a through-hole includes a first clamp and a vacuum pump. A composite magnetic shield for use at superconductive temperatures includes an inner layer with magnetic permeability of at least 50,000; and an outer layer with magnetic saturation field greater than 1.2 T, separated from the inner layer by an intermediate layer of dielectric. An apparatus to dissipate heat from a superconducting processor includes a metal carrier with a recess, a post that extends upwards from a base of the recess and a layer of adhesive on top of the post. Various cryogenic refrigeration systems are described.

Abstract: The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.

Abstract: The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.

Abstract: The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.

Abstract: The invention provides a method for delivering biologically active molecules to the eye by implanting biocompatible capsules containing a cellular source of the biologically active molecule. Also provided is a method of treating ophthalmic diseases using biocompatible capsules.

Abstract: A method and device for delivering a biologically active molecule to the eye, either intraocularly or periocularly, and method and device for treating ophthalmic disorders in a patient suffering therefrom.

Abstract: The present invention provides novel devices and methods for continuous, controlled delivery of a biologically active molecule to the eye, either intraocularly or periocularly, to treat ophthalmic disorders. A capsule is surgically placed in the desired location in the eye. The capsule includes cells which produce the biologically active molecule. The capsule also includes a surrounding biocompatible jacket through which the biologically active molecule may diffuse into the eye. This jacket may immunoisolate the encapsulated cells, protecting them from attack by the immune system of the patient.