Abstract: The invention relates to a substantially homogeneous liquid composition capable of percutaneous delivery of one or more physiologically active agents, the composition including at least one physiologically active agent, a volatile solvent, and a rate modulating carrier comprising a hydrophilic polymer and a hydrophobic polymer the combination of the hydrophilic and hydrophobic polymers being elected to enable modulation of the rate of physiologically active agent. The invention also relates to method of delivering an effective amount of an active agent and method of treatment of a patient using the composition of the invention.

Abstract: A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.