Abstract: A catheter device for implanting a medical implant such as a prosthetic heart valve has a handle configured to control/steer multiple sheaths of the catheter device. A handle includes a grip portion, a rotatable deployment knob and a traveler. An outer sheath is connected to the traveler and the deployment knob is operatively connected to the traveler such that the traveler and thereby the outer sheath are moved along the longitudinal axis with respect to the inner sheath. The handle includes a rotatable axial positioning knob and a rotatable deflection knob. The deployment knob is arranged proximally to the axial positioning knob.

Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.

Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as well as to the produced scaffolds and an associated kit. The method features a first fast drying step of applying a mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.

Abstract: Disclosed approaches monitor states of a plurality of sets of a plurality of handshake signals. Each set of handshake signals is associated with a respective one sub-circuit of a plurality of sub-circuits. For each sub-circuit, a beginning of an iteration by the sub-circuit is detected based on states of the plurality of handshake signals of the set associated with the sub-circuit. A graphics object is generated in response to detecting the beginning of the iteration. The graphics object is displayed on a display device and overlaid on a timeline associated with the sub-circuit. The graphics object has a bound that corresponds to the beginning of the iteration. The end of the iteration is detected based on the states of the associated set of handshake signals, and the graphics object is bounded on the timeline to indicate the end of the iteration.

Abstract: A torque transmission device for a powertrain of a motor vehicle has an input area and an output area. A torque path runs from the input area to the output area. A torsional vibration damping unit is positioned first, followed by a gear unit, along the torque path between the input area and the output area. The torsional vibration damping unit provides a first spatial area and an adjoining second spatial area along the torque path, and the gear unit provides an adjoining third spatial area.

Abstract: A hybrid drive module (1) for a motor vehicle includes a housing (GG), a torque converter (TC), and an electric machine with a rotor (R) and a stator (S). The rotor (R) is arranged on a rotor carrier (RT), which is fixedly connected to a hub (N). The hub (N) is rotatably supported via at least one first bearing (L1) and is supported in radial and axial directions against a bearing shield (LS). The hub (N) is rotationally fixed to a converter housing (TCH) of the torque converter (TC) via a rivet joint (RI) or a screw connection. A drive train for a motor vehicle including such a hybrid drive module (1) is also provided.

Abstract: A torque transmission device for a powertrain of a motor vehicle has an input area and an output area. A torque path runs from the input area to the output area. A torsional vibration damping unit is positioned first, followed by a gear unit, along the torque path between the input area and the output area. The torsional vibration damping unit provides a first spatial area and an adjoining second spatial area along the torque path, and the gear unit provides an adjoining third spatial area.

Abstract: The invention relates to methods for producing a polymeric scaffold for use in tissue engineering applications or soft tissue surgery, as wellto the produced scaffolds and an associated kit. The method features a first fast drying step of applying a as mechanical compression on a polymeric gel layer and a second slow drying step of the gel up to reach a polymer mass fraction of at least 60% w/w in the final scaffold. The method allows the production of scaffolds with high regeneration and healing properties of a grafted tissue via host cell invasion and colonization, and a good suturability. These goals are achieved through the formation within the scaffold of a non-uniform architecture creating softer and stiffer areas, which is maintained even upon re-swelling of the scaffold upon hydration of the final dried product.

Abstract: The invention relates to a scaffold material comprising a carrier and embedded microbeads for use in tissue engineering applications such as soft tissues therapeutic treatment. The scaffold provides a short-term bulking effect coupled with a long-term functional activity. Both the carrier and the microbeads are substantially composed of natural or extracellular matrix-derived polymers, and the beads can comprise homogeneously distributed active agents, providing a regulated agent release along time. An aspect of the invention relates to a method for producing the microbeads of the invention by using an expressly designed microfluidic chip.

Abstract: A starting element (100) for use, for example, in a drivetrain of a motor vehicle, includes a piston (310) which divides a first volume (560) that can be filled with a fluid from a second volume (570) that can be filled with a fluid, wherein the piston (310) comprises at least one fluid passage (640) which allows the fluid at least occasionally to pass through the piston (310) from the first volume (560) into the second volume (570) and/or from the second volume (570) into the first volume (560). The at least one fluid passage (640) comprises a passage component part (650) and a receiving opening (660) in the piston (310). The passage component part (650) is inserted into the receiving opening so that at least one passage opening (670) is formed which allows the fluid to pass through at least occasionally.

Abstract: A lighting device may include a semiconductor light source arrangement, a heat sink for cooling the semiconductor light source arrangement, electrical connections for supplying power to the semiconductor light source arrangement, and a holding means. The holding means is in the form of a plastic part, at least the electrical connections and the heat sink each being embedded in the plastic material of said plastic part at least in sections.

Abstract: A clutch device has a friction transmission element which has a base with at least one friction surface, at least one control element for acting on a damping device, and at least one radial support which cooperates with a stop and has a plurality of lugs which extend at least substantially radially in direction toward the stop and which are at least substantially brought closer to the stop up to a gap before the stop when the friction transmission element is stationary, while, at speed, at least a portion of the lugs comes in contact with the stop. The lugs are connected to the base via a bend which causes an axial offset with respect to the base, the bend allows a displacement of the lugs in direction toward the energy accumulators, and the lugs are completely covered by the stop in an axial extension direction.

Abstract: A clutch device has a friction transmission element which has a base with at least one friction surface, at least one control element for acting on a damping device, and at least one radial support which cooperates with a stop and has a plurality of lugs which extend at least substantially radially in direction toward the stop and which are at least substantially brought closer to the stop up to a gap before the stop when the friction transmission element is stationary, while, at speed, at least a portion of the lugs comes in contact with the stop. The lugs are connected to the base via a bend which causes an axial offset with respect to the base, the bend allows a displacement of the lugs in direction toward the energy accumulators, and the lugs are completely covered by the stop in an axial extension direction.

Abstract: A semiconductor light-emitting module includes a housing, at least one cooling body accommodated in the housing wherein the cooling body is thermally connected to at least one semiconductor light source, an active cooling device accommodated in the housing, and at least one electronics unit accommodated in the housing, at least for actuating the at least one semiconductor light source, wherein the housing has a leadthrough opening, and the at least one semiconductor light source is arranged in the region of the leadthrough opening.

Abstract: A lighting device may include a semiconductor light source arrangement, a heat sink for cooling the semiconductor light source arrangement, electrical connections for supplying power to the semiconductor light source arrangement, and a holding means. The holding means is in the form of a plastic part, at least the electrical connections and the heat sink each being embedded in the plastic material of said plastic part at least in sections.

Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an A?1-peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one A?1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune, responses within the indicated context.

Abstract: A starting element for transmitting torque from a drive-side rotational input (14) of the starting element to a driven hub (8) includes a hydrodynamic torque converter (4) which has a turbine coupled to the driven hub (8) so as to be fixed with respect to rotation relative to it and which comprises a turbine shell (56) with turbine blades (22) arranged therein. A maximum extension of the turbine shell (56) opposite an axial direction (12) terminates at a first axial position (53), and an impeller (20) located opposite the turbine in the axial direction (12). A stator (24) is arranged between the turbine and the impeller (22) and is coupled via a stator flange (58) to a freewheel (52) adjoining the driven hub (8) in an axial direction (12). A center of the freewheel (52) is located at a second axial position (54). A difference between the first axial position (53) and the second axial position (54) is greater than a predetermined minimum value.

Abstract: The holding frame is equipped for holding at least one optical element, the holding frame consisting of an opaque material.

Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.

Abstract: A starting element has a housing (4) and a guide pin (6) for centering the starting element during assembly. The guide pin (6) is made of sheet metal and is connected to the housing (4) by means of a positive connection. A method of producing such housing of a starter element is also disclosed.