Patents by Inventor Peter G. Ruminski

Peter G. Ruminski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fatty acid modified human epidermal growth factor
    Patent number: 11358994
    Abstract: The disclosure provides for new epidermal growth factor (EGF)-based reagents that have been modified by fatty acid conjugation. Method of using such agents to treatment Short Bowel Syndrome (SBS) are also described.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: June 14, 2022
    Assignee: Saint Louis University
    Inventors: Marvin J. Meyers, David C. Wood, Stacy D. Arnett, Matthew P. Yates, Peter G. Ruminski
  • Integrin antagonists
    Patent number: 11306084
    Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???? and/or ?5??. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: April 19, 2022
    Assignees: Saint Louis University, Indalo Therapeutics, Inc.
    Inventors: Peter G. Ruminski, David W. Griggs, Scott Seiwert
  • ALPHAvBETA1 INTEGRIN ANTAGONISTS
    Publication number: 20210284638
    Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???1 and/or ?5?1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 16, 2021
    Applicants: Saint Louis University, Indalo Therapeutics, Inc.
    Inventors: Peter G. RUMINSKI, David W. GRIGGS, Scott SEIWERT
  • META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
    Publication number: 20200199079
    Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Inventors: Peter G. Ruminski, David W. Griggs
  • FATTY ACID MODIFIED HUMAN EPIDERMAL GROWTH FACTOR
    Publication number: 20200190157
    Abstract: The disclosure provides for new epidermal growth factor (EGF)-based reagents that have been modified by fatty acid conjugation. Method of using such agents to treatment Short Bowel Sydnrome (SBS) are also described.
    Type: Application
    Filed: July 25, 2018
    Publication date: June 18, 2020
    Applicant: Saint Louis University
    Inventors: Marvin J. MEYERS, David C. WOOD, Stacy D. ARNETT, Matthew P. YATES, Peter G. RUMINSKI
  • Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
    Patent number: 10577330
    Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: March 3, 2020
    Assignee: Saint Louis University
    Inventors: Peter G. Ruminski, David W. Griggs
  • INTEGRIN ANTAGONISTS
    Publication number: 20190345155
    Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???? and/or ?5??. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.
    Type: Application
    Filed: December 28, 2017
    Publication date: November 14, 2019
    Inventors: Peter G. Ruminski, David W. Griggs, Scott Seiwert
  • META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
    Publication number: 20190023663
    Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 24, 2019
    Inventors: Peter G. Ruminski, David W. Griggs
  • Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
    Patent number: 10035778
    Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: July 31, 2018
    Assignee: Saint Louis University
    Inventors: Peter G. Ruminski, David W. Griggs
  • META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
    Publication number: 20180072684
    Abstract: The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 15, 2018
    Inventors: Peter G. Ruminski, David W. Griggs
  • HETERO BICYCLIC CARBOXAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS
    Publication number: 20110009435
    Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable salts thereof, processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as anti-inflammatory agents.
    Type: Application
    Filed: May 19, 2008
    Publication date: January 13, 2011
    Applicant: Pfizer, Inc.
    Inventors: Mark E. Schnute, Peter G. Ruminski, Cathleen E. Hanau, Joseph W. Stobach, Jeffery Carroll, Kirby Sample
  • Alpha v beta 3 integrin antagonists in combination with chemotherapeutic agents
    Publication number: 20030050250
    Abstract: The present invention is directed to compounds of the formula 1
    Type: Application
    Filed: December 10, 2001
    Publication date: March 13, 2003
    Inventors: Jay Cunningham, Gary B. Gordon, George A. Nickols, William F. Westlin, Thomas E. Rogers, Peter G. Ruminski
  • Para-substituted phenylene derivatives
    Patent number: 6251944
    Abstract: The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: June 26, 2001
    Assignee: G. D. Searle & Company
    Inventors: Barbara B. Chen, Helen Y. Chen, Glen J. Gesicki, Richard A. Haack, James W. Malecha, Thomas D. Penning, Joseph G. Rico, Thomas E. Rogers, Peter G. Ruminski, Mark A. Russell, Stella S. Yu
  • Meta-azacyclic amino benzoic acid compounds and derivatives thereof
    Patent number: 6013651
    Abstract: The present invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts and isomers thereof.
    Type: Grant
    Filed: March 4, 1998
    Date of Patent: January 11, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Thomas E. Rogers, Peter G. Ruminski
  • Para-substituted phenylene derivatives
    Patent number: 5952381
    Abstract: The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: September 14, 1999
    Assignee: G. D. Searle & Co.
    Inventors: Barbara B. Chen, Helen Y. Chen, Glen J. Gesicki, Richard A. Haack, James W. Malecha, Thomas D. Penning, Joseph G. Rico, Thomas E. Rogers, Peter G. Ruminski, Mark A. Russell, Stella S. Yu
  • Cinnamic acid derivatives
    Patent number: 5852210
    Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 22, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Barbara B. Chen, Helen Y. Chen, Michael Clare, Stephen H. Docter, Ish Kumar Khanna, Francis Jan Koszyk, James W. Malecha, Julie Marion Miyashiro, Thomas D. Penning, Joseph G. Rico, Peter G. Ruminski, Mark A. Russell, Richard Mathias Weier, Xiangdong Xu, Stella S. Yu, Yi Yu
  • Meta-substituted phenylene derivatives
    Patent number: 5773646
    Abstract: The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: June 30, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Nizal Chandrakumar, Barbara B. Chen, Helen Y. Chen, Michael Clare, Alan F. Gasiecki, Richard A. Haack, James W. Malecha, Peter G. Ruminski, Mark A. Russell
  • Fluoroalkenyl compounds and their use as pest control agents
    Patent number: 5627174
    Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the general structure: ##STR1## These Polar compounds are particularly useful for systemic control of pests.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: May 6, 1997
    Assignee: Monsanto Company
    Inventors: Dennis P. Phillion, Peter G. Ruminski, Gopichand Yalamanchili
  • Fluoroalkenyl compounds and their use as pest repellents
    Patent number: 5623084
    Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-l-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful for systemic control of pests. Novel method and intermediates for the preparation of 3,4,4-trifluoro-3-butene-1-amine are also provided.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: April 22, 1997
    Assignee: Monsanto Company
    Inventor: Peter G. Ruminski
  • Platelet aggregation inhibitors
    Patent number: 5602155
    Abstract: This invention herein relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing the compound and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: February 11, 1997
    Assignee: G. D. Searle & Co.
    Inventor: Peter G. Ruminski