Patents by Inventor Peter Gottlieb
Peter Gottlieb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190321448Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.Type: ApplicationFiled: June 25, 2019Publication date: October 24, 2019Inventors: Aaron Michels, Peter A. Gottlieb
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Patent number: 10363288Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.Type: GrantFiled: January 13, 2016Date of Patent: July 30, 2019Assignees: National Jewish Health, The Regents of the University of Colorado, a body corporateInventors: Aaron Michels, John Kappler, Peter A. Gottlieb
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Publication number: 20180175429Abstract: A flow battery system is provided that has at least one cell stack and at least a pair of storage containers or tanks connected to the at least one cell stack. Each of the storage containers is formed from a rigid (e.g., metal) shell and includes a liner directly bonded to inner walls of the rigid shell and forming an enclosure configured to retain a liquid electrolyte. The electrolyte can be an anolyte or catholyte. In the assembled configuration, the metal shell of the storage container provides secondary containment whereas the liner directly bonded thereto provides primary containment. The flow battery system includes a fault detection system configured to detect a presence of a fault or leak and further to determine a location of that leak in the flow battery system, such as a storage container or a specific portion of the storage container.Type: ApplicationFiled: December 18, 2017Publication date: June 21, 2018Inventors: Peter Gottlieb, Jeffrey Modderno, Michael Falcinelli, Shazad Butt
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Publication number: 20180175430Abstract: A modular flow battery includes a battery stack container housing a plurality of redox flow battery stacks in fluid communication with at least one pair of electrolyte containers including an anolyte container for holding an anolyte and a catholyte container for holding a catholyte. Additional pairs of electrolyte containers can be connected to the battery stack container to increase an amount of energy that can be stored by the modular flow battery system. Respective housings enclosing each of the battery stack container and the electrolyte containers are configured for operation in a stacked configuration. In this manner, the energy storage capacity of the modular flow battery system can be further increased with substantially no increase in a lateral area occupied by the system.Type: ApplicationFiled: December 18, 2017Publication date: June 21, 2018Inventors: Jeffrey Modderno, Peter Gottlieb, Michael Falcinelli, Shazad Butt
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Publication number: 20180116988Abstract: Methods of preventing, treating or ameliorating autoimmune diabetes by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of methyldopa. Pharmaceutical compositions containing therapeutically effective amounts of methyldopa in extended release formulations and methods of using the same are also provided.Type: ApplicationFiled: May 27, 2016Publication date: May 3, 2018Inventors: Thomas J. ANCHORDOQUY, Peter A. GOTTLIEB, Aaron MICHELS, David OSTROV
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Publication number: 20180117124Abstract: Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.Type: ApplicationFiled: January 13, 2016Publication date: May 3, 2018Inventors: Aaron MICHELS, John KAPPLER, Peter A. GOTTLIEB
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Patent number: 9820957Abstract: Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-?-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of D-?-methyldopa.Type: GrantFiled: March 22, 2017Date of Patent: November 21, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Steve Orndorff, Aaron Michels, Peter Gottlieb
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Publication number: 20170273927Abstract: Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-?-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of D-?-methyldopa.Type: ApplicationFiled: March 22, 2017Publication date: September 28, 2017Inventors: Steve Orndorff, Aaron Michels, Peter Gottlieb
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Publication number: 20170015731Abstract: Embodiments of the present invention illustrate methods of preventing transplantation rejection. In certain embodiments, a subject in need of an organ or non-organ transplantation can be pretreated with an AAT composition to reduce the incidence of transplantation rejection in the subject. Other embodiments include treating a subject with a composition including AAT before, during or after plastic surgery.Type: ApplicationFiled: September 28, 2016Publication date: January 19, 2017Inventors: Peter Gottlieb, Charles Dinarello
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Patent number: 9486509Abstract: Embodiments of the present invention illustrate methods of preventing transplantation rejection. In certain embodiments, a subject in need of an organ or non-organ transplantation can be pretreated with an AAT composition to reduce the incidence of transplantion rejection in the subject. Other embodiments include treating a subject with a composition including AAT before, during or after plastic surgery.Type: GrantFiled: March 27, 2014Date of Patent: November 8, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Peter Gottlieb, Charles Dinarello
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Patent number: 8935111Abstract: The disclosed system includes a metering device for monitoring electrical power grid conditions, a controller for determining if the metering device is detecting a condition on an electrical grid that is indicative of a delayed voltage recovery event, and a communication device for communicating with one or more remotely located bi-directional power source modules connected to the electrical power grid, wherein the controller is programmed to send a notification via the communication device to the one or more remotely located bi-directional power source modules if the controller detects a condition indicative of delayed voltage recovery event. In some embodiments, the metering device includes a grid metering device. In some embodiments, the metering device measures power factor, and a change in the voltage and ratio of VARs to Watts.Type: GrantFiled: September 28, 2010Date of Patent: January 13, 2015Assignee: NEC Energy Solutions, Inc.Inventors: Charles Vartanian, C. Michael Hoff, David Colucci, Peter Gottlieb
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Patent number: 8593015Abstract: A battery system comprises a first battery unit; a DC voltage bus; a second battery unit electrically connected to the DC voltage bus; a current-limiting component; and switching circuitry for connecting the first battery unit to the DC voltage bus, where the switching circuitry is configured to electrically connect the first battery unit to the DC voltage bus either directly or through a current-limiting component, depending on an operating parameter of the first battery unit.Type: GrantFiled: October 28, 2010Date of Patent: November 26, 2013Assignee: A123 Systems LLCInventors: Peter Gottlieb, C. Michael Hoff, Thomas Farkas
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Publication number: 20130116844Abstract: The grid load synchronization system described herein permits proactive mitigation of the effects of large loads transitioning on and off the power grid and the resultant risks and power quality issues associated therewith. The disclosed proactive system permits a grid-connected power consumer to synchronize demand with power storage equipment in real time using a digital communication link. The power consumer transmits requests to bring a load online or offline to a control site. The control site coordinates power grid source(s) and power grid loads to maintain power quality when loads go on and offline. The control sites manage requests from multiple power consumers and schedule the various loads for the consumers to mitigate the effects of large loads transitioning on and off the power grid. The resulting power quality can be guaranteed when adequate battery resources are made proactively available, rather than reacting to line conditions to engage compensation actions.Type: ApplicationFiled: December 3, 2010Publication date: May 9, 2013Applicant: A123 Systems, Inc.Inventors: John M. McNally, Peter Gottlieb
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Publication number: 20120225813Abstract: Embodiments herein concern compositions and methods for treating diabetes in a subject.Type: ApplicationFiled: June 13, 2011Publication date: September 6, 2012Inventors: Eli C. LEWIS, Peter GOTTLIEB, Charles A. DINARELLO, Leland SHAPIRO, Aaron MICHELS
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Publication number: 20120104856Abstract: A battery system comprises a first battery unit; a DC voltage bus; a second battery unit electrically connected to the DC voltage bus; a current-limiting component; and switching circuitry for connecting the first battery unit to the DC voltage bus, where the switching circuitry is configured to electrically connect the first battery unit to the DC voltage bus either directly or through a current-limiting component, depending on an operating parameter of the first battery unit.Type: ApplicationFiled: October 28, 2010Publication date: May 3, 2012Applicant: A123 SYSTEMS, INC.Inventors: Peter GOTTLIEB, C. Michael HOFF, Thomas FARKAS
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Publication number: 20110112017Abstract: Embodiments herein concern compositions and methods for treating diabetes in a subject.Type: ApplicationFiled: June 11, 2010Publication date: May 12, 2011Inventors: Lee SHAPIRO, Charles A. DINARELLO, Eli LEWIS, Peter GOTTLIEB, Amy WALLACE, Aaron MICHELS, Gregory B. POTTS
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Publication number: 20110074215Abstract: The disclosed system includes a metering device for monitoring electrical power grid conditions, a controller for determining if the metering device is detecting a condition on an electrical grid that is indicative of a delayed voltage recovery event, and a communication device for communicating with one or more remotely located bi-directional power source modules connected to the electrical power grid, wherein the controller is programmed to send a notification via the communication device to the one or more remotely located bi-directional power source modules if the controller detects a condition indicative of delayed voltage recovery event. In some embodiments, the metering device includes a grid metering device. In some embodiments, the metering device measures power factor, and a change in the voltage and ratio of VARs to Watts.Type: ApplicationFiled: September 28, 2010Publication date: March 31, 2011Applicant: A123 SYSTEMS, INC.Inventors: Charles VARTANIAN, C. Michael HOFF, David COLUCCI, Peter GOTTLIEB
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Patent number: 7872374Abstract: An uninterrupted power supply (“UPS”) system is disclosed which uses a battery communication system to communicate to a UPS processor information concerning the status of a battery pack in an array of parallel coupled battery packs. The battery packs provide back-up power for the UPS system. Information about the battery packs is collected by a monitor associated with each of the battery packs. The monitors measure battery pack voltage, currents and temperature and compile information about the battery pack from the measured values. Each monitor prepares a data word representing information about its battery pack. The data words are transmitted to the UPS in response to commands issued by the UPS processor to the monitors.Type: GrantFiled: July 28, 2008Date of Patent: January 18, 2011Assignee: American Power Conversion CorporationInventors: Peter A. Gottlieb, Rodger B. Dowdell, Jr.
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Publication number: 20080278006Abstract: An uninterrupted power supply (“UPS”) system is disclosed which uses a battery communication system to communicate to a UPS processor information concerning the status of a battery pack in an array of parallel coupled battery packs. The battery packs provide back-up power for the UPS system. Information about the battery packs is collected by a monitor associated with each of the battery packs. The monitors measure battery pack voltage, currents and temperature and compile information about the battery pack from the measured values. Each monitor prepares a data word representing information about its battery pack. The data words are transmitted to the UPS in response to commands issued by the UPS processor to the monitors.Type: ApplicationFiled: July 28, 2008Publication date: November 13, 2008Applicant: American Power Conversion CorporationInventors: Peter A. Gottlieb, Rodger B. Dowdell, JR.
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Patent number: 7411315Abstract: An uninterrupted power supply (“UPS”) system is disclosed which uses a battery communication system to communicate to a UPS processor information concerning the status of a battery pack in an array of parallel coupled battery packs. The battery packs provide back-up power for the UPS system. Information about the battery packs is collected by a monitor associated with each of the battery packs. The monitors measure battery pack voltage, currents and temperature and compile information about the battery pack from the measured values. Each monitor prepares a data word representing information about its battery pack. The data. words are transmitted to the UPS in response to commands issued by the UPS processor to the monitors.Type: GrantFiled: February 13, 2007Date of Patent: August 12, 2008Assignee: American Power Conversion CorporationInventors: Peter A. Gottlieb, Rodger B. Dowdell, Jr.