Abstract: A system and method for lifecycle automation of workflow processes. The system includes a memory and one or more processors to execute computer-readable instructions stored in the memory to perform a method. The method has the following steps. First, authorizing access via a dashboard or API to a centralized library repository. The centralized library repository hosts shared automation configuration. The shared automation configuration is configured to be selected via a blueprint profile or by the user team and applied to a managed repository. Second, generating a configuration file. The configuration file defines the shared automation configuration parameters for the managed repository. Lastly, committing the configuration file to the managed repository thereby committing the shared automation configuration to the managed repository. The system is configured to track inputs to the shared automation configuration and propagate changes that result from the input to impacted managed repositories.

Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.

Abstract: The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.

Abstract: The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in Burkholderia thailandensis (bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as a Burkholderia strain comprising a bta cluster (e.g. Burkholderia thailandensis (e.g. E264, Bt4, and TXDOH) and Burkholderia pseudomallei (e.g. K96243, 1106a, and 1106b).

Abstract: Compounds described herein are useful in modulating bacterial quorum sensing.

Abstract: Compounds described herein are useful in modulating bacterial quorum sensing.

Abstract: A cold temperature light fixture comprises an insulated housing having one or more ballasts and plural lamps to retain heat within enclosure so that ballasts and lamps start up more rapidly, and greater light output is obtained. The fixture may be operated in selected configurations and may include secondary heating elements within the fixture to warm ballasts. In one operating configuration, one or more of the ballasts is always energized and one or more of the lamps is preferably at least partially illuminated in an off mode. A sensor is operable to switch the fixture between the off and on mode, in which all ballasts are energized and all lamps illuminated.

Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.

Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.

Abstract: The present invention relates to methods for the modulation of biofilm formation and antibiotic resistance. Specifically, the present invention identifies the differential expression of biofilm-associated genes in biofilms, relative to their expression in non-biofilm producing bacterial cells. The present invention also identifies the differential expression of biofilm-associated genes in biofilms treated with antibiotic, relative to their expression in untreated biofilms. The present invention describes methods for the diagnostic evaluation of biofilm formation. The invention also provides methods for identifying a compound capable of modulating biofilm formation and antibiotic resistance. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of biofilm-associated diseases or disorders.

Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.

Abstract: Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signalling in bacteria using the compounds of the invention are also described.

Abstract: An integral backpack/upper body garment comprises a garment to which a split backpack is attached or attachable to the back panel of an upper body garment. A front backpack assembly including front assembly with shoulder straps is attached/attachable to the front face of the back panel, and a rear backpack assembly including storage compartments is attached/attachable to the rear face of the back panel. A circumferential garment compartment has two walls, one attached to the front assembly and one attached to the rear assembly. The jacket may be rolled up or folded into the garment compartment and the two walls joined by a closure to protectively enclose the garment therein when it is not worn. The backpack may be worn with or without the integral jacket, and the jacket may be worn with or without the backpack.