Patents by Inventor Peter Grenville Houghton

Peter Grenville Houghton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing indole derivatives containing a 1,2,4-triazol-1-yl substituent
    Patent number: 5717104
    Abstract: A process for preparing tryptamine derivatives and related compounds having a 1,2,4-triazol-1-yl moiety within the molecule comprises reacting 4-amino-1,2,4-triazol with a nitrobenzene derivative containing a readily displaceable group; deaminating the aminotriazolium salt thereby obtained by treatment with nitrous acid followed by neutralisation; reducing the triazolyl-ni-trobenzene derivative thereby obtained by transfer hydrogenation; treating the triazolyl-aniline derivative thereby obtained with nitrous acid and then with an alkali metal sulphate, followed by acidification; and subsequently reacting the triazolyl-hydrazine derivative thereby obtained in situ with a suitable carbonyl compound, to obtain the required triazolyl-indole derivative.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: February 10, 1998
    Assignee: Merck, Sharp & Dohme, Ltd.
    Inventor: Peter Grenville Houghton