Abstract: A method of manufacturing a microtitre plate with wells having transparent bottoms, where the microtitre plate includes at least one physical deformation between at least two adjacent wells.

Abstract: A microtitre plate with wells having transparent bottoms, wherein the microtitre plate includes at least one physical deformation between at least two adjacent wells. The physical deformations may have the shape of e.g. a channel, a ridge, a hole, a slit or a step.

Abstract: A liquid dispensing apparatus comprises a liquid reservoir (32), an outlet port (6; 36) and driving means for forcing liquid (4) through the outlet port (6, 36). The driving means generates a pulse of gas which impinges upon the liquid (4) in the reservoir (32) so as to force liquid (4) through the outlet port (6, 36). Also disclosed is a cassette comprising a plurality of cartridges for dispensing liquid therefrom. Each cartridge comprises a liquid reservoir (32) and an outlet member (36) mounted so as to close an opening (34) in the liquid reservoir (32). The outlet member (36) provides an outlet port through which the liquid can be forced by a pulse of pressurised gas.

Abstract: The present invention provides an apparatus for simultaneously monitoring an array of reaction sites for light indicating that a reaction is taking place at a particula site comprising a charge-coupled device (CCD) arranged so that in use the light from a particular reaction site will impinge upon a particular predetermined region of the CCD. The apparatus also has means for determining the light level impinging upon each of the predetermined regions and means to record the variation of light level with time for each of the reaction sites. Also disclosed is a method of identifying a target base in a DNA sequence using such an apparatus.

Abstract: The invention refers to a tubular member, such as a pipette tip, for binding nucleic acid molecules for a subsequent biomolecular reaction, to methods for at least partly performing a sequencing-by-synthesis reaction in a tubular member, to an automated system using the tubular member for performing the methods of the invention, and kits and computer programs for use in relation to the methods of the invention. By performing a sequencing-by-synthesis reaction in a tubular member, such as a pipette tip, a new format for enzymatic reactions of this type, i.e. sequencing by synthesis, is provided.

Abstract: A structure for the absorption or desorption of a substance on a bed through which liquid is allowed to pass comprises a vessel containing a liquid-permeable bed, a lower adaptor, an upper adaptor and means for providing a liquid flow to the bed through one of the adaptors and means for conducting a liquid flow away from the bed through the other adaptor. The lower adaptor is arranged in the lower part of the vessel and at least partially defines the vessel bottom. The lower adaptor has an opening for the passage of liquid to or from the lower part of the vessel, which opening is directed toward the bed, and the lower adaptor is provided with a distribution facility for distributing or collecting liquid flow towards or from, respectively, a bottom surface of the bed. The upper adaptor is arranged in an upper part of the vessel and at least partially covers a cross-sectional area of the vessel.