Abstract: This disclosure is directed at specific acrylic PSA compositions that are capable of resisting a broad array of solvents. Acrylic PSA's primarily derived from C?1#191-C?4#191 acrylate monomers and functional acrylates exhibit a strong resistance to a wide array of solvents, including both polar and non-polar solvents.

Abstract: The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.

Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.

Abstract: The invention relates to allograft transplantation. More particularly, the invention relates to prolonging the survival of transplanted allografts. The invention provides a new method for improving allograft survival in a mammal. The method according to the invention provides a synergistic effect between lactacystin or lactacystin analogs and immunosuppressive drugs to prolong the survival of transplanted allografts in a mammal.

Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.

Abstract: This invention is directed to the treatment of inflammatory and autoimmune diseases by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof. The invention is further directed to the treatment of inflammatory and autoimmune diseases by administering an effective combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixture thereof. Pharmaceutical compositions comprising a combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixture thereof are also contemplated within the scope of the invention.

Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.

Abstract: This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.

Abstract: A disk file includes multiple disk surfaces, on which servo information is recorded, with an offset in azimuth from one disk surface to another. Each head comprises a magnetoresistive stripe for reading and an inductive write coil. The servo system reads servo information from each disk in turn, multiplexing the signals from each disk together to form a single position error signal (PES). The separation of the servo multiplexer, attached to the MR stripes, from the write multiplexer, attached to the inductive coils, avoids problems due to contamination of the servo signal by the write signal. A least squares fit is used to generate the PES from the series of servo samples from each disk surface.

Abstract: A magnetic disk drive is provided with a system and method for writing a servo pattern after the head disk assembly (HDA) is sealed. A clock track is written inside the sealed HDA using a Monte Carlo technique. The clock track is read by a magneto-optical head through a window in the HDA housing, and the time transitions therefrom are used to control the product heads. The entire servo pattern for the disk drive is thus written with the HDA unit completely sealed.

Abstract: A head positioning system with automatic gain control for use in disk information storage apparatus employs multiphase radial position error signals derived from position reference information on the disk to control the position of a transducing head by means of a head positioning actuator. A variable gain amplifier amplifies the signals from the transducing head prior to their application to a position error signal generating means. The gain of the amplifier is controlled in a gain control loop by a gain function. The gain function is derived by combining the differnet phase position error signals to provide, at any position of the head, a measurement of the rate of change of the position error signals per track of displacement. This system affords gain control which is substantially independent of head width and limits variations in offtrack gain between heads.